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Large Granular Lymphocytes Leukemia: A Case Report with a Review of the Literature
Maryam Mouamin,
Ghita Badou,
Hicham Yahyaoui,
Imane Benjelloun,
Mohamed Raissi,
Mustapha Ait Ameur,
Mohamed Chakour
Issue:
Volume 8, Issue 1, February 2020
Pages:
1-4
Received:
6 December 2019
Accepted:
26 December 2019
Published:
9 January 2020
Abstract: Larges granulars lymphocytes (LGL) leukemias correspond to rare haemopathies secondary to clonal proliferation of larges lymphocytes rich in azurophilic granules with phenotype T of CD3+ or CD3- (NK cell) profile. We report the case of a patient, 75 years old, who was admitted for pancytopenia associated with lymphocytosis at 8G / L all evolving in a febrile context. The clinical examination did not find tumoral syndrome. The blood smear founded very numerous granulars lymphocytes representing 46% of all lymphocytes. The myelogram shows an aspect in favor of peripheral thrombocytopenia without other notable abnormalities. There is a cellular expansion of CD8+ NK T cells compatible with LGL-type proliferation. The bone marrow is infiltrated by these lymphocytes with a percentage of 28%. It is a pathology with an heterogeneous spectrum classified by the World Health Organization into three entities: LGL T leukemia and chronic NK cell expansions with chronic and indolent evolution and aggressive cell leukemia NK with usually a reserved prognosis. Recent advances in the knowledge of the pathophysiology of these haemopathies have made it possible to specify the mechanisms underlying the perpetuation of the LGL clone and to identify new therapeutic targets.
Abstract: Larges granulars lymphocytes (LGL) leukemias correspond to rare haemopathies secondary to clonal proliferation of larges lymphocytes rich in azurophilic granules with phenotype T of CD3+ or CD3- (NK cell) profile. We report the case of a patient, 75 years old, who was admitted for pancytopenia associated with lymphocytosis at 8G / L all evolving in...
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Andrew Obrzut - Eminent Polish Professor, First Head of the Department of Pathological Anatomy (1896-1910) of the Medical Faculty of Lviv University
Dmytro Zerbino,
Liliya Volos
Issue:
Volume 8, Issue 1, February 2020
Pages:
5-10
Received:
17 November 2019
Accepted:
9 December 2019
Published:
16 January 2020
Abstract: This paper presents an overview of the history of life, scientific and pedagogical activity, major achievements of a great Polish pathologist Andrew Obrzut. Andrew Obrzut was born in Poland, studied at the Medical Faculty of the Jagiellonian University in Cracow (Poland) and received a diploma of the Doctor of Medicine. Andrew Obrzut was a student of the founder of the Czech Institute of Pathological Anatomy Yaroslav Hlava and in 1887 defended his dissertation for the post-doctorate scientific degree of medicine on the topic “About blood’s participation in the onset of the inflammatory process” in Prague. In 1891-1896 he was a professor in the Department of Pathological Anatomy at the at Charl’s University in Prague. Andrew Obrzut greatly influenced the development of Pathological Anatomy in Poland, Czechy and Ukraine. In 1896, he accepted the proposal of Yaroslav Hlava to organise a department of pathological anatomy at Lviv University. On 9th December 1896, the first lecture “On the Importance of Pathological Anatomy for Medical Education” was read to the students of the third year of study in the Faculty of Medicine of Lviv University, in the lecture hall, by the doctor of medicine, Professor Andrew Obrzut and this day is considered the date of foundation of the department. Andrew Obrzut - the organiser of the Museum of Human Diseases (1896-1910) of the Medical Faculty. The scientific achievements of A. Obrzut are summarised in unique publications published in German, Polish, French, and Czech language about new research on the pathogenesis of glomerulonephritis, tuberculosis, caseous pneumonia, amyloid degeneration and others. However, the first of all his merits for the readership of Polish and Ukraine pathologists was his a two-volume textbook on Pathological Anatomy and Bacteriology. Andrew Obrzut remains an outstanding example of a very careful and precise pathologist.
Abstract: This paper presents an overview of the history of life, scientific and pedagogical activity, major achievements of a great Polish pathologist Andrew Obrzut. Andrew Obrzut was born in Poland, studied at the Medical Faculty of the Jagiellonian University in Cracow (Poland) and received a diploma of the Doctor of Medicine. Andrew Obrzut was a student ...
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Socio-demographic and Clinical Characteristics of Regular Blood Donors Receiving Free Blood Bags at The National Blood Transfusion Center in Côte d’Ivoire
Sekongo Yassongui Mamadou,
Konan Sidoine,
Kouamenan Sidonie,
Tiembre Ibrahima,
Tchimou Jeremie,
Konate Seidou
Issue:
Volume 8, Issue 1, February 2020
Pages:
11-14
Received:
12 January 2020
Accepted:
21 January 2020
Published:
4 February 2020
Abstract: The objective of this study is to review the activities of free delivery of blood bags to the regular blood donors at the National Blood Transfusion Center of Abidjan Treichville. Il was a descriptive cross-sectional study that took place at the National Blood Transfusion Center in Abidjan from 1 January to 31 March 2015. Were Included in the study all regular blood donors who presented themselves for free blood bags at the blood distribution service in Treichville during the defined period. 74 regular blood donors were included. The data has been saved and processed by Epi info 6.04Fr. The age group of 32-41 years predominated with 40.55% followed by that of 22-31 years with 27.03%. For the beneficiaries, to equal value, the free of blood bags for mother and child predominated with 22.97% followed by the husband with 21.62% of cases of free In 55.40% of cases, the justification for the transfusion was severe anemia. At the end of our study, we can retain for our study population, that they are young blood donors having generally benefited from a single case of free. Regarding the right-holders for free to regular blood donors, we noted a predominance with equal values for the mother and for the child. It would be interesting for the whole population to feel concerned about the donation of blood because each of us is a potential transfused patient.
Abstract: The objective of this study is to review the activities of free delivery of blood bags to the regular blood donors at the National Blood Transfusion Center of Abidjan Treichville. Il was a descriptive cross-sectional study that took place at the National Blood Transfusion Center in Abidjan from 1 January to 31 March 2015. Were Included in the study...
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Species Diversity of Candida from Hospital Environment in Plateau State, Nigeria
Nnaemeka Emmanuel Nnadi,
Miri Alexander Nanpyal,
Nanpon Kaduna,
Bege Jonathan,
Iskender Karalti
Issue:
Volume 8, Issue 1, February 2020
Pages:
15-19
Received:
8 January 2020
Accepted:
20 January 2020
Published:
7 February 2020
Abstract: In the past few years the role the hospital environment in the transmission of infections has increased leading to the increase in the incidence of morbidity and mortality associated with Candida infections. The hospital environment can serve as an alternative niche for the presence of opportunistic pathogens of public health concern. This study sought to use molecular approach to study the prevalence of Candida from hospital environments in Jos, Plateau State, Nigeria. Samples were collected from different hospital environments and cultured on Chromagar Candida media. Taqman PCR was then used to characterize the isolates, the ability of Candida to form biofilm was evaluated. In this study, Candida parapsilosis with 31.25% was the most prevalent Candida followed by Candida (Nakaseomyces) glabrata and Candida krusei with prevalence of 28.13%. The ability to form biofilms was evaluated for these environmental isolates, and it was observed that C. parapsilosis biofilm formation correlated with high prevalence with C. parapsilosis having high biofilm formation (20/64) followed by C. glabrata and C. krusei (18/64) each Environmental sampling has the potential to improve our knowledge about yeast biodiversity and the evolution of pathogenic yeasts with clinical relevance. This study is the first in Nigeria to study to characterize Candida from hospital environments in Jos, Plateau state Nigeria.
Abstract: In the past few years the role the hospital environment in the transmission of infections has increased leading to the increase in the incidence of morbidity and mortality associated with Candida infections. The hospital environment can serve as an alternative niche for the presence of opportunistic pathogens of public health concern. This study so...
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Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit
Yassongui Mamadou Sekongo,
Kabore Saydou,
Kouakou Boidy,
Kouamenan Sidonie,
Kassogue Kadidja,
N’Guessan Parfait,
Oue Nabo Bertin,
Konate Seidou,
Sanogo Ibrahima
Issue:
Volume 8, Issue 1, February 2020
Pages:
20-24
Received:
15 January 2020
Accepted:
27 January 2020
Published:
7 February 2020
Abstract: In Côte d'Ivoire, sickle cell disease affects 14% of the population. It is responsible for significant morbidity and mortality. Transfusion is a significant element in the management of major sickle cell anemia, which exposes them to post-transfusion hemochromatosis. The biological diagnosis is based on the determination of serum iron and the transferrin saturation coefficient (CST). As the determination of the CST was not available in our exercise context in Côte d'Ivoire, we determined only the ferritinemia. The interest of this work lies in the therapeutic implication linked to the identification of patients at risk of hemochromatosis because chelators are difficult to access for most patients. This was a prospective, descriptive and analytical study, on polytransfused sickle cell patients, followed at the transfusion therapy unit (UTT) of the CNTS of Abidjan, from 2010 to 2018. We included 78 sickle cell patients, all ages and genders who have received at least ten transfusions. The ferritinemia assay was carried out by ELISA. Transfusion exchange, with 59% of cases, was the most used mode of transfusion. The mean ferritinemia was 1719.19 ng / ml. Hyperferritinemia was found in 63% of patients. Most of the patients were on a long-term transfusion program with an average of 27.5 bags of red blood cell concentrates. Thirty-two patients had received at least 20 bags of red blood cell concentrates. We noted 21 patients treated, including 3 with deferoxamine and 18 treated with oral deferasirox. We have identified 33 sickle cell anemia patients at risk for hemochromatosis. The determinants of the risk of hemochromatosis were the high number of blood bags and the method of transfusion.
Abstract: In Côte d'Ivoire, sickle cell disease affects 14% of the population. It is responsible for significant morbidity and mortality. Transfusion is a significant element in the management of major sickle cell anemia, which exposes them to post-transfusion hemochromatosis. The biological diagnosis is based on the determination of serum iron and the trans...
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