Profile of Birth Injuries in a Tertiary Hospital in Enugu, Nigeria
Chukwubuike Kevin Emeka,
Ekwochi Uchenna,
Enebe Joseph Tochukwu,
Nduagubam Obinna Chukwuebuka,
Eze Thaddeus Chikaodili,
Iheji Chukwunonso Chigozie
Issue:
Volume 7, Issue 5, October 2019
Pages:
99-103
Received:
31 August 2019
Accepted:
16 September 2019
Published:
7 October 2019
Abstract: Background: Birth injury is defined as structural damage of a newborn secondary to mechanical forces that occur during labor and/or delivery. This study determined the incidence, risk factors and outcome of birth injury. Methodology: This was an observational study of birth injuries in neonates, over a period of one year, carried out at a tertiary hospital in Enugu, south east, Nigeria. Results: Out of the 1,735 births recorded during the period of the study, there were 19 cases of birth injuries. This gave an incidence of 11 per 1000 live births. No neonate had more than one injury. They were thirteen males and six females that sustained birth injury. Cephalohematoma was the most common birth injury. Others are caput succedaneum, clavicular fracture, Erb’s palsy, femoral fracture, humeral fracture, shoulder dislocation and facial laceration. Mode of delivery, neonatal birth weight, gestational age and maternal parity were significant predictive risk factors for birth injury. Conclusion: In the current study, cephalohematoma was the most common birth injury, followed by caput succedaneum. There is need to reduce the morbidity and mortality associated with birth injuries.
Abstract: Background: Birth injury is defined as structural damage of a newborn secondary to mechanical forces that occur during labor and/or delivery. This study determined the incidence, risk factors and outcome of birth injury. Methodology: This was an observational study of birth injuries in neonates, over a period of one year, carried out at a tertiary ...
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Lunar Magnetism Orchestrates Menstrual Cycle in Symphony of Life
Venkata Subba Rao Yeragudipati
Issue:
Volume 7, Issue 5, October 2019
Pages:
104-109
Received:
26 July 2019
Accepted:
28 August 2019
Published:
9 October 2019
Abstract: Female humans have an internal menstrual cycle rhythmicity that helps them anticipate and adapt to the regular rhythm of the Lunar Month and intensity of Moon Light. But how does this menstrual cycle rhythmicity work? This paper presents my discovery elucidating female menstrual cycle rhythmicity and its inner workings with Lunar cycle rhythmicity and Moon Light intensity. Moon plausibly controls the hypothalamus which is responsible for producing the hormone that triggers the start of female menstrual cycle. The five different hormones released from the hypothalamus have a different effect on the anterior pituitary gland, stimulating it to release or stop releasing a particular hormone in tune with the lunar phases of waxing and waning. The discovery explains how female humans’ menstrual cycle adapt their physiology and biological rhythm so that it is synchronised with the Moon’s rotations and its phases both of which holds a plausible relationship in duration of their phases and in the volume of intensity of moonlight due to waxing or waning with that of the thickening or dissolution of the endometrium besides the growth of one single large egg cell for fertilisation; and in the absence of fertilisation bring about dissolution. Thus, deciphering of female human menstrual cycle rhythmicity leading to the plausible pregnancy is a cosmic process due to combined effect of Interplanetary Magnetic Field (IMF) and Geomagnetic Field (GMF). This opens up whole new fields of research which helps in treating irregular monthly periods and infertility by a suitable magnetic therapy. The intensity of moonlight varies greatly depending on the current lunar phase. The phases of the moon are the result of the earth's shadow being cast on the surface of the moon. In short, the reflected light from the moon being also electromagnetic wave interacting with Geomagnetic Field modulates female menstrual rhythmicity cycle of all its phases and also helps in normalising monthly periods by exposure to natural light besides helps in finding suitable magnetic therapy for infertility.
Abstract: Female humans have an internal menstrual cycle rhythmicity that helps them anticipate and adapt to the regular rhythm of the Lunar Month and intensity of Moon Light. But how does this menstrual cycle rhythmicity work? This paper presents my discovery elucidating female menstrual cycle rhythmicity and its inner workings with Lunar cycle rhythmicity ...
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2-Deoxy-D-glucose Mediates Dihydrodiol Dehydrogenases Over-expression and Cisplatin Resistance in Human Cervical Cancer Cells
Jianli Chen,
Rong Wu,
John Zihou Chen,
Visitacion Pabicon,
Monika Wrzolek,
Fiona Simpkins,
Henry Simpkins
Issue:
Volume 7, Issue 5, October 2019
Pages:
110-120
Received:
30 September 2019
Accepted:
14 October 2019
Published:
23 October 2019
Abstract: Dihydrodiol dehydrogenases (DDHs) belong to a superfamily of cytosolic NADP (H)-dependent oxidoreductases. The over-expression of DDHs induces cisplatin resistance. 2-Deoxy-D-glucose (2-DG), a glucose analogue, is currently being used as an anticancer reagent. In this study we investigated the effect of 2-DG on DDHs expression and cisplatin resistance in human cervical cancer 2008 and C13 cells. We employed RT-PCR to detect mRNA level of DDH1, DDH2, and DDH3 and western blotting for protein expression. The cisplatin resistance was investigated with MTT and colony formation assays. Apoptosis/necrosis and mitochondrial membrane potential analysis were evaluated with flow cytometry. The intracellular ROS regulation was evaluated with H2DCFDA probe. We used 2-DG resistant cells to demonstrate the effect of 2-DG on DDHs expression and cisplatin resistance. 2-DG significantly up-regulated the mRNA level and protein expression of DDH1, DDH2, and DDH3, which consequently increased cisplatin resistance as confirmed by MTT and colony formation assays. In the 2-DG-resistant cells, the apoptosis/necrosis percentage and intracellular ROS were significantly decreased. 2-DG itself could activate JNK. When treating the cells combined with cisplatin, 2-DG attenuated cisplatin-mediated JNK phosphorylation. 2-DG down-regulated wild-type p53 protein expression at lower 2-DG concentrations (1/2 IC50 and IC50) at 24-hour. Activated JNK attenuation and decreased p53 expression by 2-DG implied the underlying resistance mechanism. Our study highlighted that 2-DG, as an anticancer reagent currently, could be a two-side sword that also significantly inhibited apoptosis by up-regulating DDHs expression and consequently increased cisplatin resistance in the human cervical cancer cells we used.
Abstract: Dihydrodiol dehydrogenases (DDHs) belong to a superfamily of cytosolic NADP (H)-dependent oxidoreductases. The over-expression of DDHs induces cisplatin resistance. 2-Deoxy-D-glucose (2-DG), a glucose analogue, is currently being used as an anticancer reagent. In this study we investigated the effect of 2-DG on DDHs expression and cisplatin resista...
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