-
MP-1™ Polyimide for Medical Devices: 1. Pre Clinical Studies
Peter James Burn,
Alisa Buchman,
Simha Sibony,
Amir Oron
Issue:
Volume 7, Issue 3, June 2019
Pages:
42-51
Received:
30 April 2019
Accepted:
12 June 2019
Published:
2 July 2019
Abstract: Due to constant increase in human life expectancy, more people require primary and revision total hip replacement surgeries, costing billions of US$ per year. Currently used ceramic on X-linked Polyethylene appears to be the best choice by default, but it still wears. The wear particles generated, are the major cause of osteolysis and joint failure. During 2011-14, leading orthopedic companies suffered global recalls of their MoM hip systems resulting in thousands of revision surgeries. The search continues for new and more durable materials bearing materials. Developments in medical technology have increased the demand for advanced materials due to aging population, advanced medical procedures and contagious diseases. Metals and ceramics are prevalent in the medical industry. However, the unique properties of polymeric materials exhibit potential as better replacements for conventional materials. MMATECH Ltd. has developed a new articulation liner made of a revolutionary material of the Polyimide family, MP-1™, a spin-off of the Aerospace industry. MP-1™ has proved to be biocompatible, heat-resistant, highly crosslinked, combining unusual strength, toughness, self-lubrication, excellent friction and wear durability, as well as resistance to fatigue, creep, impacts and chemicals. These properties lead to longer life span and safer articulating implanted components. MMATECH received the CE and ISO certificates for its MP-1™ Acetabular liner of hip implant based on a pilot clinical study conducted in New-Zealand with excellent 13y follow-up results. Ethical Committee approval was granted for a clinical study of 100 patients in New Zealand. The results of the first 82 surgeries follow-up demonstrated normal blood parameters, no osteolysis, and improved quality of life. The performance of MP-1™ even at 13 years is very promising and is now being applied to younger patients (~ 40 Y old) in view of the retrieval data. Part 1 of this research will summarize the pre-clinical studies while Part 2 will deal with the clinical studies.
Abstract: Due to constant increase in human life expectancy, more people require primary and revision total hip replacement surgeries, costing billions of US$ per year. Currently used ceramic on X-linked Polyethylene appears to be the best choice by default, but it still wears. The wear particles generated, are the major cause of osteolysis and joint failure...
Show More
-
Utilization of Job’s Tear (Coix Lacryma-Joba L.) Flour as Composite for All Purpose Flour in Saltine Crackers
Cherry Jane Naingue Andoy,
Iren Vy Ruiz Enot,
Aireen Jane Dominguez Mabaza,
Ive Joy Cases Quillo
Issue:
Volume 7, Issue 3, June 2019
Pages:
52-56
Received:
10 May 2019
Accepted:
27 June 2019
Published:
9 July 2019
Abstract: Nowadays, urbanization and smaller households are influencing Filipino consumers in procuring convenience food products. As a convenience food and a potential staple food, saltine crackers were made in this study by combining Job’s tear (adlay) flour (Coix lacryma-Joba L.) and all-purpose flour to develop an improved convenience food product with high nutritional quality. All Purpose flour was added in different levels to Job’s tear flour making four (4) treatments (0, 15, 30 and 45% w/w) in the production of saltine crackers. The moisture, pH and ash content of the products were analyzed. The results of the test shows a significant difference in its ash content (%) which ranges from 3.10-3.20%, pH from 6.27-7.23 and moisture content (%) 1.37-10.47%. T4 (45%) contains the highest moisture which means that the higher adlay flour added as composite, the higher the moisture content. T3 (30%) shows the highest in ash content which is 3.20% and is primarily due to the ratio of the amount of all-purpose flour and adlai flour in the mixture. The sensory acceptability of the Adlay Saltine Crackers correspondingly shows a significant difference wherein T3 (30%) has the highest sensory score in terms of overall acceptability. T3 (30%) is also the most acceptable in terms of color, aroma and texture while T4 (45%) is the least acceptable in terms of its sensory properties.
Abstract: Nowadays, urbanization and smaller households are influencing Filipino consumers in procuring convenience food products. As a convenience food and a potential staple food, saltine crackers were made in this study by combining Job’s tear (adlay) flour (Coix lacryma-Joba L.) and all-purpose flour to develop an improved convenience food product with h...
Show More
-
Down Standardization Process and Prospects
Wang Yicheng,
Wang Shaoping
Issue:
Volume 7, Issue 3, June 2019
Pages:
57-62
Received:
21 February 2019
Accepted:
4 April 2019
Published:
11 July 2019
Abstract: The internationalization process of the standardization development of down products in China is relatively slow. This paper analyzes the standardization of the national standard and international standard of down products, between the current domestic and international standards for down products, there are some differences in the type of project and the limit value of the index. The development idea of improving the quality of down products by promoting the standardization of down products is put forward. The purpose is to promote the international development process of the down industry in China.
Abstract: The internationalization process of the standardization development of down products in China is relatively slow. This paper analyzes the standardization of the national standard and international standard of down products, between the current domestic and international standards for down products, there are some differences in the type of project ...
Show More
-
Prevalence and Multi-Drug Resistance Pattern of Food Poisoning Enteric Bacteria Associated with Diarrhoea Patients
Douye Victor Zige,
Christian Kosisochukwu Anumudu
Issue:
Volume 7, Issue 3, June 2019
Pages:
63-67
Received:
6 March 2019
Accepted:
26 April 2019
Published:
12 July 2019
Abstract: Diarrhoea continues to be a burden especially in developing countries of Africa. However, the treatment of diarrhoea is complicated due to the increase in resistance of enteric and food poisoning bacteria to commonly utilized antibiotics. This work was focused on the identification of enteric bacteria pathogens implicated in cases of diarrhoea orchestrated by food poisoning by use of specialized identification media and biochemical assays. Eight different bacteria species including; E. coli, S. typhi, Non-typhoid Salmonella, Proteus sp., Pseudomonas aeruginosa, Citrobacter sp., Klebsiella sp. and Non-Sorbitol utilizing E. coli were isolated from diarrhoea patients in Yenagoa, Nigeria with different frequencies. Of all isolates, E. coli had the highest frequency of occurrence (29.9%), followed by Proteus sp. (20.8%), Non-typhoid Salmonella (19.3%) and S. typhi (10.7%). Other isolates had frequencies less than 10% respectively. The isolated enteric bacteria were subjected to antibiotics susceptibility assay by the Kirby-Bauer method using Ofloxacin (5μg), Ciprofloxacin (5μg), Gentamicin (10μg), Ceftazidine (30μg), Nitrofuratoin (300μg), Augmentin (30μg), Cefixime (5μg) and Cefuroxime (30μg). All the bacteria isolates assayed showed 100% resistance to Ceftazidine and Cefuroxime while all isolates with the exception of one Citrobacter sp. was resistant to augmentin, thus indicating the unsuitability of these drugs in the treatment of diarrhoea. Majority of the bacteria isolates showed multidrug resistance patterns, with E. coli, Proteus sp. and Klebsiella sp. showing a 100% resistance to the same six (Ceftazidine, Cefuroxime, Gentamycin, Cefixime, Nitrofuratoin and Augmentin) out of the eight antibiotics assayed. This is of public health significance and shows a growing trend of multidrug resistance to commercially available antibiotics utilized in the management of diarrhoea which can cause an increase in morbidity and mortality associated with acute diarrhoea.
Abstract: Diarrhoea continues to be a burden especially in developing countries of Africa. However, the treatment of diarrhoea is complicated due to the increase in resistance of enteric and food poisoning bacteria to commonly utilized antibiotics. This work was focused on the identification of enteric bacteria pathogens implicated in cases of diarrhoea orch...
Show More
-
Burden of Unplanned Antenatal Visits in a Tertiary Hospital in Nigeria: Making a Case for an Improved Referral System
Awoleke Jacob Olumuyiwa,
Olofinbiyi Babatunde Ajayi,
Awoleke Adeola Olabisi,
Olofinbiyi Rebecca Oluwafunke
Issue:
Volume 7, Issue 3, June 2019
Pages:
68-72
Received:
4 June 2019
Accepted:
3 July 2019
Published:
13 July 2019
Abstract: Non-urgent unplanned visits are frequently observed in pregnancy. However, there are no studies from Nigeria exploring its burden. A cross-sectional cohort survey of 1,182 women at the only state-owned teaching hospital in Ado - Ekiti was conducted to address this need. One-quarter of the population studied had unplanned antenatal visits during the period of care. Only about one in four of the reasons for the unplanned visits were ‘direct’ pregnancy-related complaints, while the largest proportion of the women, 227 (73.5%), visited on account of infectious morbidities, followed by gastrointestinal disorders, 63 (20.4%). Mothers who were skilled workers were significantly more likely to have unplanned antenatal visits compared with their unemployed counterparts (45.3% versus 20.7%, p = 0.013). Unplanned visits were significantly more in women who had reduced fetal movements (9.4% versus 0.9%, p < 0.0001); significantly more women who had out-of-schedule prenatal visits were admitted for care (37.9% versus 0.2%, p < 0.0001), and had induction of labour (20.1% versus 10.3%, p < 0.0001) when compared with those who had no unplanned visits. Reduced maternal perception of fetal movements (odds ratio: 7.57; 95% C. I. 3.07 - 18.70, p < 0.0001), prenatal admission (odds ratio: 241.81; 95% C. I. 59.02 - 990.75, p < 0.0001), and induction of labour (odds ratio: 1.90; 95% C. I. 1.24 - 2.93, p = 0.003) were found to be independently associated with unplanned antenatal visits.
Abstract: Non-urgent unplanned visits are frequently observed in pregnancy. However, there are no studies from Nigeria exploring its burden. A cross-sectional cohort survey of 1,182 women at the only state-owned teaching hospital in Ado - Ekiti was conducted to address this need. One-quarter of the population studied had unplanned antenatal visits during the...
Show More
