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Immunoglobulin a in Chronic Periodontitis Patients
Issue:
Volume 3, Issue 4-1, July 2015
Pages:
1-3
Received:
11 February 2015
Accepted:
13 February 2015
Published:
2 March 2015
Abstract: Fourty-nine chronic periodontitis patients were diagnosed by dentist .Of which 27 were with generalized chronic periodontitis and 22 were with localized chronic periodontitis. The disease was prevalent among the age group range from 20 to 44 years old. Ten apparently healthy normal subjects were elected as control .Sera , saliva, salivary proteins were made for detection of IgA levels using radial immunodiffusion in gel containing low and high levels of anti-IgA ready made makes. Periodontitis patients sera have shown that, IgA concentration means reachs two to three folds higherthan that of controls.The IgA herd plot among the patients was of skewd distribution type. Young patients serum IgA were showing higher than that of senescence periodontitis patients and higher than that of normal control subjects .Male patients serum IgA were of higher concentration means than that of female patients. Apparently senescence decreases serum IgA concentration means as compared to young patients and controls.
Abstract: Fourty-nine chronic periodontitis patients were diagnosed by dentist .Of which 27 were with generalized chronic periodontitis and 22 were with localized chronic periodontitis. The disease was prevalent among the age group range from 20 to 44 years old. Ten apparently healthy normal subjects were elected as control .Sera , saliva, salivary proteins ...
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Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis
Ibrahim M. S. Shnawa,
Baha H. H. Alamiedi,
Zainab M. H. Al Fatlawy
Issue:
Volume 3, Issue 4-1, July 2015
Pages:
4-6
Received:
11 February 2015
Accepted:
13 February 2015
Published:
2 March 2015
Abstract: Fourty-Nine chronic periodontitis patients were diagnosed by the dentist of the team. Of which 27 were generalized chronic and the other 22 were localized chronic periodontitis. Ten subjects with normal mouth hygienewere considered as controls. Blood,and saliva samples were collected from both of the test patients and controls. Sera, saliva and salivary proteins were subjected to C3 and C4 determinations using ready made plates ofradial immunodiffusion in gel containing anti-C3 and anti-C4 antibodies. Generalized chronic periodontitis patients were showing higher C3 levels than localized chronic periodontitis patients. Both of thedisease forms were of higher C3 and C4 levels than controls. Females have lower C3 levels than male chronic periodontitis patients. C4 levels were slightly increased than normal control levels. Male C4 levels approximate female levels. Four cases ofC3 and C4 hypercomplementemia in each of the disease forms.One extremecombinedC3 and C4 hypercomplementemia in the generalized form and one extreme C4 hypercomplementemiawas noted in the localized form. Thus, normo, hyper and extreme hypercomplementemia C3 and C4 were noted among chronic periodontitis patients. These hypercomplementemia cases are secondary non-genetic, infection and /or inflammation induced.
Abstract: Fourty-Nine chronic periodontitis patients were diagnosed by the dentist of the team. Of which 27 were generalized chronic and the other 22 were localized chronic periodontitis. Ten subjects with normal mouth hygienewere considered as controls. Blood,and saliva samples were collected from both of the test patients and controls. Sera, saliva and sal...
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Oral Mucosal Immune Tolerance Versus Oral Immune Silencing: Mini Review
Issue:
Volume 3, Issue 4-1, July 2015
Pages:
7-9
Received:
18 February 2015
Accepted:
2 March 2015
Published:
6 March 2015
Abstract: Oral mucosal tolerance a phenomenon among others in the common mucosal immune system. The mechanisms behind which are multiple. Three main opinions are being raised up .First ,tolerant cells emerged within the gut mucosa and migrates to oral mucosa suppressing immune function ,the second holds that tolerant cells evolved with in the sublingual salivary glands and functions insitue and the third ,however ,considered tolerance as an active immune processes marked with hypersensitivity and antibody formation.
Abstract: Oral mucosal tolerance a phenomenon among others in the common mucosal immune system. The mechanisms behind which are multiple. Three main opinions are being raised up .First ,tolerant cells emerged within the gut mucosa and migrates to oral mucosa suppressing immune function ,the second holds that tolerant cells evolved with in the sublingual sali...
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IgM-IgG-IgA Secondary Mixed Cryoglobulinemia Associated with Pediatric Tonsillitis
Issue:
Volume 3, Issue 4-1, July 2015
Pages:
10-12
Received:
28 February 2015
Accepted:
5 March 2015
Published:
12 March 2015
Abstract: A cryoprotein was separated from sera of the pediatric tonsillitis patients. Such protein characterized as: percipitable at 4c , dissolvable at 37c and repercipitable at 4c. It showed gelatinous or crystalline texture. The immunochemical quantitation using single radial immune diffusion for immunoglobulin isotypes revealed mixed IgM-IgG-IgA isotypes. Hence secondary mixed cryoglobulinemia type III was proven in association with pediatric tonsillitis rate of 29:30(96.66%).
Abstract: A cryoprotein was separated from sera of the pediatric tonsillitis patients. Such protein characterized as: percipitable at 4c , dissolvable at 37c and repercipitable at 4c. It showed gelatinous or crystalline texture. The immunochemical quantitation using single radial immune diffusion for immunoglobulin isotypes revealed mixed IgM-IgG-IgA isotype...
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Oral Mucosal Tolerance Versus Systemic Immune Response to Salmonella typhi Antigen
Ibrahim Mohamed Saeed Shnawa,
Zainab Khudhur Ahmed Al-Mahdi
Issue:
Volume 3, Issue 4-1, July 2015
Pages:
13-16
Received:
17 March 2015
Accepted:
28 March 2015
Published:
23 April 2015
Abstract: It was demonstrated that the oral vaccine application of Salmonella typhi antigen can activate low antibody agglutinin titer (mean:40±0) comparing with high agglutination titer induced by Intramuscular administration of Salmonella typhi antigen (mean 560.0 ± 51.64) as well as anti-Salmonella typhi IgG ELIZA shows high mean index value(mean = 0.6957±0.10) comparing with the low index value induced by oral rout were (mean= 0.028±0.014) while anti Salmonella typhi IgM ELIZA test show mean index value = 0.6339±0.0385 comparing with low IgM index value (mean= 0.1560±0.070) induced by oral rout (Rsquared 0.7457, t test 3.3. The pro –inflammatory cytokines IL-1α was high in intramuscular rout 217.089±39.78 than its concentration with in oral administrated group (100.4±12.09), IL-12 was about the same concentration both in oral rout and intramuscular rout subsequently (23.607 and 23.17) p value 0.01, R squared (0.3958).However the immune responses were not absolutely absent in the oral administrated group, this reflect the fact that there is a selectivity in taking oral antigens from digestive mucosal surfaces but this immune feature and selectivity theme may vary from antigen to another. In conclusion the recent and ongoing expansion of a new information about the mucosal and systemic immune responses lend a promise to provide the tools needed to exploit the full potential and development of both mucosal and intramuscular vaccines.
Abstract: It was demonstrated that the oral vaccine application of Salmonella typhi antigen can activate low antibody agglutinin titer (mean:40±0) comparing with high agglutination titer induced by Intramuscular administration of Salmonella typhi antigen (mean 560.0 ± 51.64) as well as anti-Salmonella typhi IgG ELIZA shows high mean index value(mean = 0.695...
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The Interplay of the Local Microbiome with Oral Mucosal Immune Compartment: Minireview
Ibrahim Mohamed Saeed Shnawa
Issue:
Volume 3, Issue 4-1, July 2015
Pages:
17-19
Received:
20 May 2015
Accepted:
20 May 2015
Published:
29 May 2015
Abstract: The oral microbiome is formed and functioned in balanced state during health and in an unbalanced state in the disease conditions. Microbiome in the oral compartment combats the weapons of the invading microbial pathogens .Now , there are a specific microbiome signature in each of the cases of health and disease. Oral microbiome expressed; probiotic, antigenic competition and immunomodulatory effects locally in the oral compartment .In the immunologic sense ,oral microbiome is constituting an element that is able to interact in a bidirectional fashion with the components of the oral immune compartment with the net result of homiostasis , immune response ,tolerance ,anergy and hypersensitivity and/or immune mediated diseases .Thus it has played an important roles in oral immune mechanisms.
Abstract: The oral microbiome is formed and functioned in balanced state during health and in an unbalanced state in the disease conditions. Microbiome in the oral compartment combats the weapons of the invading microbial pathogens .Now , there are a specific microbiome signature in each of the cases of health and disease. Oral microbiome expressed; probioti...
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