-
Anti-Oxidative Activity of Fruit Extracts of Some Medicinal Plants Used against Chronic Diseases (Diabetes, Hypertension) in Kankan, Guinea
Oulare Kabine,
Barry Mamadou Samba,
Bah Fatoumata,
Keita Namagan,
Haba Nyanga Luopou,
Balde Aliou Mamadou
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
1-5
Received:
30 October 2014
Accepted:
2 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.11
Downloads:
Views:
Abstract: Ethnobotanical surveys in Kankan (Guinea) led to an inventory of 78 plants used in the treatment of hypertension and diabetes. Among them, 31 plants producing edible fruits were selected. From these, 16 were anti- hypertensive, 8 anti- diabetic and 7 were used to treat hypertension as well as diabetes. The strongest anti-oxydative activity was observed in the hydro alcoholic fruit extracts of Tamarindus indica L. (116.75 %), Diospyros mespiliformis Hochst. ex A. DC. (111.75 %), Strychnos spinosa Lam. ( 111.71 %) and Aframomum melegueta ( 111.12 %). The alcoholic extracts of Cissus aralioides (Welw. Ex Bak. ), Cola cordifolia (Cav. ) R. Br., Gardenia ternifolia, Syzygium guineense (Willd.) DC were devoid of any antioxidant activity.
Abstract: Ethnobotanical surveys in Kankan (Guinea) led to an inventory of 78 plants used in the treatment of hypertension and diabetes. Among them, 31 plants producing edible fruits were selected. From these, 16 were anti- hypertensive, 8 anti- diabetic and 7 were used to treat hypertension as well as diabetes. The strongest anti-oxydative activity was obse...
Show More
-
Evaluation of Antibacterial Activity of Some Medicinal Plants Used in the Treatment of Sexually Transmitted Infections (STI) in Guinean Traditional Medicine
Barry Mamadou Samba,
Oulare Kabiné,
Traore Mohamed Sahar,
Balde Mamadou Aliou,
Diallo Mamadou Saliou Telly,
Camara Aïssata,
Diallo Mamadou Saidou,
Guilavogui Patrice,
Bah Mamadou Kabirou,
Bah Fatoumata,
Sow Mamadou Alpha,
Barry Raïhanatou,
Soumah Fodé Salifou,
Camara Fatou Souleymane,
Vlietinck Arnold Joseph,
Vanden Berghe D. A.,
Balde Aliou Mamadou
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
6-10
Received:
30 October 2014
Accepted:
2 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.12
Downloads:
Views:
Abstract: Microbial infections such as sexually transmitted infections are very common in Guinea. Due to the high cost of conventional medicines, the pharmacopeia along with the traditional medicine remains the main medical resources for most of the Guinean populations. An ethnobotanical survey of some medicinal plants used in the traditional treatment of sexual infectious diseases in the district of Kankan led to the inventory of 33 plant species belonging to 17 families. All of the tested extracts were inactive against Salmonella typhimurium. Except the extracts of Spondias mombin and Markhamia tomentosa and Anogeissus leiocarpus which showed the highest antibacterial (62, 5 µg/ml) effect against Bacillus cereus and/or Klebsiella pneumoniae and Staphylococcus aureus, all the other extracts exhibited a narrow spectrum of antibacterial activity. This study supports partly the traditional claims of these plants as a remedy to infectious diseases.
Abstract: Microbial infections such as sexually transmitted infections are very common in Guinea. Due to the high cost of conventional medicines, the pharmacopeia along with the traditional medicine remains the main medical resources for most of the Guinean populations. An ethnobotanical survey of some medicinal plants used in the traditional treatment of se...
Show More
-
Ethnobotanical Survey, Antimicrobial and Anticomplement Activities of Guinean Medicinal Plants Traditionally Used in the Treatment of Inflammatory Diseases in Conakry and Dubreka
A. M. Baldé,
M. S. Traoré,
M. S. T. Diallo,
E. S. Baldé,
Y. Huang,
Z. Liu,
K. Oularé,
M. S. Barry,
M. A. Baldé,
A. Camara,
D. Vanden Berghe,
A. Vlietinck,
L. Pieters
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
11-19
Received:
30 October 2014
Accepted:
2 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.13
Downloads:
Views:
Abstract: Based on an ethnobotanical survey related to inflammatory diseases, 67Guinean plant species belonging to 35 botanical families were inventoried. Some plant species frequently used in the treatment of rheumatism, skin diseases and microbial infections were selected and submitted to a biological investigation including antimicrobial and anticomplement activities. At a concentration of 1mg/ml, all the tested extracts were devoid of any activity against the tested fungi viz Candida albicans, Aspergillus niger, and Trichophyton rubrum and showed a cytotoxicity varying from 0.25 to 500 µg/ml which prevented the evaluation of possible antiviral effects against herpes simplexvirus type 1, Coxsackie-B2, Measle Edmondston A, Poliomyelitis virus type 1, Semliki forest L10 and Vesicular stomatitis virus for viruses. At 1mg/ml, only the extracts ofAgeratum conyzoides, Alchornea cordifolia, Acanthospermum hispidum, Erythrina senegalensis, Harungana madagascariensis, Hymenocardia acida, and Lophira alata showed an antibacterial effect against Bacillus cereus and/or Staphylococcus aureus. All the tested extracts exhibited an inhibitory effect on the Alternative Complement Pathway complement except for Bambusa vulgaris. Only the extracts of Ageratum conyzoides and Hymenocardia acida interfered with both activation pathways of the complement system. The results of the present work support the anti-inflammatory traditional use of some selected plant species which could be explained, at least partly, by their anticomplement properties.
Abstract: Based on an ethnobotanical survey related to inflammatory diseases, 67Guinean plant species belonging to 35 botanical families were inventoried. Some plant species frequently used in the treatment of rheumatism, skin diseases and microbial infections were selected and submitted to a biological investigation including antimicrobial and anticomplemen...
Show More
-
Quinic Acid Esters from Pavetta owariensis var. owariensis (Rubiaceae)
Baldé A. M.,
Pieters L. A.,
Claeys M.,
Traoré M. S.,
Baldé M. A.,
Diallo,
M. S. T.,
Baldé E. S.,
Diané S.,
Vlietinck A. J.
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
20-23
Received:
30 October 2014
Accepted:
2 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.14
Downloads:
Views:
Abstract: The stem-bark of Pavetta owariensis var. owariensis is used in Guinean traditional medicine as an anthelmintic. Previous biological and chemical investigations reported the in vivo and/or in vitro anthelmintic, antischistosomal, antiviral and antibacterial properties along with the presence of a wide range of proanthocyanidins possessing a doubly-linked structure and ferulic acid esters substances. From the stem-bark, five previously known quinic acid esters have been isolated for the first time. Their structures have been established by means of FAB-mass, 1H and 13CNMR spectroscopy.
Abstract: The stem-bark of Pavetta owariensis var. owariensis is used in Guinean traditional medicine as an anthelmintic. Previous biological and chemical investigations reported the in vivo and/or in vitro anthelmintic, antischistosomal, antiviral and antibacterial properties along with the presence of a wide range of proanthocyanidins possessing a doubly-l...
Show More
-
Efficacy and Safety of Englerina lecardii (Engl.) Balle in the Treatment of Type 2 Diabetes
E. S. Balde,
N. M. Balde,
M. S. Traore,
M. A. Diallo,
I. V. Camara,
M. S. T. Diallo,
M. A. Balde,
A. Camara,
A. M. Balde
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
24-27
Received:
31 October 2014
Accepted:
4 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.15
Downloads:
Views:
Abstract: The use of phytomedicine to treat many chronic diseases as diabetes is current in developing countries and pharmacological data in some case support this use. The aim of this study is to evaluate the efficacy and safety of Englerina lecardii leaves in the treatment of type 2 diabetes. An open label study design was designed to examine the effects of leave of Englerina lecardii at a dose of 15g/day in three divided doses during 90 days in 31 subjects with type 2 diabetes. 25 patients (9 men and 16 women ; age ) completed the study. On average, glycaemia at the end of treatment was decreased by 80 mg/dl (+-xx). Only mild and temporary side effects were observed, without leading to interrupt the treatment. In conclusion, the use of Englerina lecardii showed significant hypoglycemic effect without any major side effect. These data need to be confirm in a standard double blinded clinical trial.
Abstract: The use of phytomedicine to treat many chronic diseases as diabetes is current in developing countries and pharmacological data in some case support this use. The aim of this study is to evaluate the efficacy and safety of Englerina lecardii leaves in the treatment of type 2 diabetes. An open label study design was designed to examine the effects o...
Show More
-
Chemotherapeutical Evaluation of Borreria verticillata Extracts
Balde A. M.,
Pieters L. A.,
Traore M. S.,
Camara A.,
Balde M. A.,
Oulare K.,
Barry M. S.,
Diallo M. S. T.,
Balde E. S.,
Diane S.,
Vlietinck A. J.
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
28-31
Received:
3 November 2014
Accepted:
6 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.16
Downloads:
Views:
Abstract: In the Guinean traditional medicine, Borreria verticillata is widely used in the treatment of skin diseases. Extracts of the plant species were found to exhibit in vitro moderate to weak antimicrobial activity against Staphylococcus aureus, Streptococcus viridans, Streptococcus pneumoniae, Neisseria gonorrhoeae, Mycobacterium fortuitum, Gardnerella vaginalis, human immunodeficiency virus (HIV), Candida albicans and Candida tropicalis. The antimicrobial action is closely related to the presence of alkaloids.
Abstract: In the Guinean traditional medicine, Borreria verticillata is widely used in the treatment of skin diseases. Extracts of the plant species were found to exhibit in vitro moderate to weak antimicrobial activity against Staphylococcus aureus, Streptococcus viridans, Streptococcus pneumoniae, Neisseria gonorrhoeae, Mycobacterium fortuitum, Gardnerella...
Show More
-
Ethnobotanical Survey of Medicinal Plants Traditionally Used in Low and Middle - Guinea for the Treatment of Skin Diseases
M. A. Balde,
M. S. Traore,
S. Diane,
M. S. T. Diallo,
T. M. Tounkara,
A. Camara,
E. S. Baldé,
F. Bah,
U. Ouedraogo,
H. Drame,
H. Diallo,
A. M. Balde
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
32-39
Received:
6 November 2014
Accepted:
10 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.17
Downloads:
Views:
Abstract: From an ethnobotanical survey conducted in Low and Middle Guinea, 98 traditional healers and 76 herbalists were interviewed. An increasing involvement of female as traditional practitioners was observed, particularly in Low Guinea where they represented 57% (62/109) of the total traditional practitioners specialized in the treatment of skin diseases. A total of 104 plant species were listed. Of these, 96 from 87 genera and 38 families were identified for the treatment of various skin diseases. Fabaceae was the most represented family while the most cited plant species (28 to 17 times) were Uvaria chamae, Uvariopsis guineensis, Alchornea cordifolia, Sarcocephalus esculentus, Cassia sieberiana. The most cited plant parts were leaves 57% (79/139), root-bark 17% (24/139) and stem-bark 13% (18/139). The proportions of plant species were 24% (35/146) for the treatments of impetigo, 22% (32 /146) for scabies, 8% (12/146) for prurigo and eczema, 7% (11/146) for ringworm etc. The decoction and the maceration were the most used in the preparation forms of the recipes. Further research is needed to isolate and identify the active compounds and understand their biological activities.
Abstract: From an ethnobotanical survey conducted in Low and Middle Guinea, 98 traditional healers and 76 herbalists were interviewed. An increasing involvement of female as traditional practitioners was observed, particularly in Low Guinea where they represented 57% (62/109) of the total traditional practitioners specialized in the treatment of skin disease...
Show More
-
Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine
Diallo M. S. T.,
Baldé M. A.,
Camara A.,
Traoré M. S.,
Bah M. L.,
Diallo A. S.,
Camara A. K.,
Laurent S.,
Roch A.,
Muller R. N.,
Maes L.,
Pieters L.,
Baldé A. M.
Issue:
Volume 3, Issue 1-2, January 2015
Pages:
40-46
Received:
21 November 2014
Accepted:
24 November 2014
Published:
27 December 2014
DOI:
10.11648/j.jps.s.2015030102.18
Downloads:
Views:
Abstract: From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.
Abstract: From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinan...
Show More
