Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats
Baozhong Diao,
Weirong Jin,
Feng E. Zhang,
Wenzhou Zhang
Issue:
Volume 6, Issue 3, May 2018
Pages:
64-68
Received:
26 March 2018
Accepted:
12 April 2018
Published:
24 May 2018
Abstract: objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent.
Abstract: objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was...
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Multiple Sclerosis Clinic in Iraq, an Endeavourforan Unraveling Database
Haider Ali Mohammed,
Mohammed Majeed kamil,
Hassan Naji Aboud,
Bahaa Hassan
Issue:
Volume 6, Issue 3, May 2018
Pages:
69-82
Received:
28 February 2018
Accepted:
28 March 2018
Published:
29 May 2018
Abstract: Multiple sclerosis (MS) is the most common disabling neurologic condition of young adults after trauma. The establishing of an unraveling database carries a potentially important role in clarifying the nature of the disease in Iraq. This study had been designed to find the frequency distribution of MS patients according to different demographic variables like the age at onset, age at diagnosis, gender and place of birth and residence, etc, to estimate the frequency of different neurological symptoms and signs in patients with MS, to estimate the frequency of different clinical types of MS in Iraqi patients and assessing the differences between different clinical types of MS in regard to gender, age at onset, age at diagnosis, the diagnostic delay, disease duration and the EDSS, accordingly. This retrospective study was carried out at the Multiple Sclerosis Clinic, Medical City in Baghdad/lraq. The medical files of 900 MS patients were thoroughly revised; they included all patients who had attended the MS Clinic from the day of establishment of the clinic at 2001 to the end of February 2006. Six hundreds seventy six (676) patients were considered as MS patients fulfilling the Poser's criteria and continued visiting the clinic for follow up and treatment. Patient's distribution according to the clinical type of their MS was RRMS= 67.3%, PPMS= 19.1%, SPMS= 13.6% , main age distribution of this sample was between 30-39 years (39.3%).,Females were 64.9%, males were 35.1%.,Age of onset was mainly between 20-29 years of age regardless of the gender or type of MS, Diagnostic delay was mainly between 1-3 years, Distribution according to place of birth was seen mainly in 3 geographical clusters in Iraq, Motor symptoms were the commonest experienced by the patients (95.7%). This study had shown that during the last 2 decades, MS was increasingly encountered in Iraq, particularly during the last 5 years after the establishment of MS clinic in Baghdad, MS cases in Iraq distributed in a three-main-clusters pattern rather than North-South gradient, primary progressive MS showed a more even gender distribution and older age at onset with the shortest diagnostic delay.
Abstract: Multiple sclerosis (MS) is the most common disabling neurologic condition of young adults after trauma. The establishing of an unraveling database carries a potentially important role in clarifying the nature of the disease in Iraq. This study had been designed to find the frequency distribution of MS patients according to different demographic var...
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Multidisciplinary Management of Lung Destruction Presenting with Massive Hemoptysis and Asphyxia
Xiaowen He,
Guoxing Chen,
Xueming He,
Zhongliang He
Issue:
Volume 6, Issue 3, May 2018
Pages:
83-86
Received:
23 April 2018
Accepted:
8 May 2018
Published:
30 May 2018
Abstract: Lung destruction with massive hemoptysis is a life-threatening condition associated with a poor prognosis in the absence of prompt management. Asphyxia due to the flooding of the airways rather than exsanguination is usually the cause of death, so the initial treatment is resuscitation and protecting the airway. Prompt identification of its causes and location is mandatory to do an adequate treatment and to avoid fatal complications. We describe the case of a patient who was an emergency admission with large volume hemoptysis and asphyxia. After lung destruction was confirmed the cause of massive hemoptysis by a chest computed tomography (CT)，She underwent bronchial artery embolization (BAE) and controlled the bleeding. But due to recurrent bleeding two days later, she performed pneumonectomy and achieved hemostasis. BAE is now considered as first-line therapy or may be used as a tool to stabilize the patient before surgery. Emergency pneumonectomy is indicated for lung destruction with recurrent hemoptysis not controlled by embolization and is generally considered a last resort.
Abstract: Lung destruction with massive hemoptysis is a life-threatening condition associated with a poor prognosis in the absence of prompt management. Asphyxia due to the flooding of the airways rather than exsanguination is usually the cause of death, so the initial treatment is resuscitation and protecting the airway. Prompt identification of its causes ...
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