objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 6, Issue 3) |
| DOI | 10.11648/j.ajcem.20180603.11 |
| Page(s) | 64-68 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Ketangmin (KTM), Streptozotocin-Induced Diabetic Symptoms, Potential Mechanisms
| [1] | Frank L. Bowling, S. Preventing and treating foot complications associated with diabetes mellitus. Nature Reviews Endocrinology 11,606–616, (2015) |
| [2] | T. Vetrichelvan, M. Jegadeesan, and B. A. U. Devi. "Anti-diabetic activity of alcoholic extract of Celosia argentea LINN. seed in rats," Biological and Pharmaceutical Bulletin, vol. 25, no. 4, pp.526-528, 2002. |
| [3] | Naoto Egawa, Yingsong Lin, Taku Tabata et al., ABO blood type, long-standing diabetes, and the risk of pancreatic cancer. World J Gastroenterol. 2013 Apr 28; 19(16): 2537–2542. |
| [4] | Bharti SK, Krishnan S, Kumar A. Phytotherapy for diabetes mellitus: back to nature. Minerva Endocrinol. 2015 Nov 12. |
| [5] | Szarka A1, Horemans N, Passarella S et al. Demonstration of an intramitochondrial invertase activity and the corresponding sugar transporters of the inner mitochondrial membrane in Jerusalem artichoke (Helianthus tuberous L.) tubers. Planta. 2008 Oct; 228(5):765-75. |
| [6] | M. W Massing, C. A. Sueta, M. Chowdhury, D. P. Biggs, and R. J. Simpson Jr., "Lipid manage-ment among coronary artery disease patients with diabetes mellitus or advanced age," The American Journal of Cardiology, vol. 87, no. 5, pp. 646-649, 2001. |
| [7] | S. A. Metz, "Oxygenation products of antimonic acid: third messengers of insulin release," Prostaglandins, vol. 27, pp. 147-151, 1984. |
| [8] | V Chen and C. D. Ianuzzo, "Dosage effects of streptococci on rat tissue enzyme activities and glycogen concentration; Canadian Journal of Physiology and Pharmacology, vol. 60, no. 10, pp. 1251-1256,1982. |
| [9] | A. R. Chaudry, M. Alam, M. Ahmad, F. Z. Khan, and N. Nomani, "Studies on medicinal herbs. II: effect of Colchicum luteumonbio chemical parameters of rabbit serum; Fitoterapia, vol. 64, no. 6, pp. 510-515, 1993. |
| [10] | M. Y Donath and S. E. Shoelson, "Type 2 diabetes as an inflammatory disease; Nature Re-views Immunology, vol. ll, no. 2, pp. 98-107, 2011. |
| [11] | A. Chawla, K. D. Nguyen, and Y P. S. Goh, "Macrophage mediated inflammation in metabolic disease; Nature Reviews Immunology, vol. 11, no. 11, pp. 738-749, 2011. |
| [12] | J. Spranger, A. Kroke, M. Mohlig et al., "Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study" Diabetes, vol. 52, no. 3, pp. 812-817, 2003. |
| [13] | G. S. Hotamisligil, P. Arner, J. F. Caro, R. L. Atkinson, and B. M. Spiegelman, "Increased adi-pose tissue expression of tumor necrosis factor-a in human obesity and insulin resistance," Journal of Clinical Investigation, vol. 95, no. 5, pp. 2409-2415, 1995. |
| [14] | C. Cavelti-Weder, A. Babians-Brunner, C. Keller et al., "Effects of grievously on glycemia and inflammatory markers in type 2 diabetes; Diabetes Care, vol. 35, no. 8, pp.1654-1662, 2012. |
APA Style
Baozhong Diao, Weirong Jin, Feng E. Zhang, Wenzhou Zhang. (2018). Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats. American Journal of Clinical and Experimental Medicine, 6(3), 64-68. https://doi.org/10.11648/j.ajcem.20180603.11
ACS Style
Baozhong Diao; Weirong Jin; Feng E. Zhang; Wenzhou Zhang. Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats. Am. J. Clin. Exp. Med. 2018, 6(3), 64-68. doi: 10.11648/j.ajcem.20180603.11
AMA Style
Baozhong Diao, Weirong Jin, Feng E. Zhang, Wenzhou Zhang. Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats. Am J Clin Exp Med. 2018;6(3):64-68. doi: 10.11648/j.ajcem.20180603.11
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Download@article{10.11648/j.ajcem.20180603.11,
author = {Baozhong Diao and Weirong Jin and Feng E. Zhang and Wenzhou Zhang},
title = {Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {6},
number = {3},
pages = {64-68},
doi = {10.11648/j.ajcem.20180603.11},
url = {https://doi.org/10.11648/j.ajcem.20180603.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20180603.11},
abstract = {objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent.},
year = {2018}
}
TY - JOUR T1 - Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats AU - Baozhong Diao AU - Weirong Jin AU - Feng E. Zhang AU - Wenzhou Zhang Y1 - 2018/05/24 PY - 2018 N1 - https://doi.org/10.11648/j.ajcem.20180603.11 DO - 10.11648/j.ajcem.20180603.11 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 64 EP - 68 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20180603.11 AB - objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent. VL - 6 IS - 3 ER -
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