Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture
Jannatul Fardous,
Faria Farzana Perveen,
Md Zahidul Islam,
A. H. M. Saifuddin,
Sakina Sultana
Issue:
Volume 3, Issue 5, October 2017
Pages:
67-70
Received:
28 July 2016
Accepted:
22 February 2017
Published:
31 October 2017
Abstract: In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days.
Abstract: In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that...
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In-vitro Antimicrobial Properties and Phytochemical Constituents of Anthocleista djalonensis Leaf Extracts
Ijeoma Solomon Okoro,
Sampson Dominic Umoh,
John Vershima Anyam,
Manasseh Msugh-Ter Manyi,
Cynthia Adegbe
Issue:
Volume 3, Issue 5, October 2017
Pages:
71-76
Received:
21 August 2017
Accepted:
18 September 2017
Published:
20 November 2017
Abstract: This study investigated the claims of traditional practitioners in the use of Anthocleista djalonensis for the treatment of various diseases and infections in Benue State, Nigeria. The leaves of the plant were collected; air dried; pulverized and successively extracted using hexane, ethyl acetate, ethanol and methanol by microwave assisted method. The phytochemical analysis of the leaf extracts of Anthocleista djalonensis revealed the presence of glycosides, saponins, terpenes, sterols flavonoids, anthraquinones, resins and balsams in Anthocleista djalonensis leaf. The antimicrobial screening of the hexane, ethyl acetate, ethanol and methanol extracts were carried out on Methicillin Resistant Staphylococcus aureus, Vancomycin Resistant enterococci, Staphylococcus aureus, Helicobacter pylori, Candida albicans, Candida krusei, Candida tropicalis, Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa using agar-well diffusion method. The antimicrobial studies showed that all the extracts exhibited activities against Methicillin Resistant Staphylococcus aureus, Vancomycin Resistant enterococci, S. aureus, H. pylori, C. albicans, and C. krusei with significant zones of inhibition ranging from 16 - 20 mm for hexane extract, 22 - 28 mm for ethyl acetate extract, 20 - 24 mm for ethanol extract and 20 - 23 mm for methanol extract against test microbes. E. coli, P. aeruginosa, P. mirabilis and C. tropicalis showed resistance to the extracts; Minimum Inhibitory Concentration (MIC) of the extracts against the stated microbes were 5 mg/mL, 5 mg/mL, 5 mg/mL, 5 mg/mL, 2.5 mg/mL and 5 mg/mL respectively for hexane extract. 1.25 mg/mL, 1.25 mg/mL, 0.62 mg/mL, 0.62 mg/mL 0.62 mg/mL and 1.25 mg/mL respectively for ethyl acetate extract; Ethanol and methanol extracts recorded 1.25 mg/mL against all the stated test microbes. The minimum bactericidal/fungicidal concentration of the extracts against Methicillin Resistant Staphylococcus aureus, Vancomycin Resistant enterococci, S. aureus, H. pylori, C. albicans and C. krusei ranged from 5 mg/mL to 1.25 mg/mL. The results support the use of Anthocleista djalonensis in traditional medicine.
Abstract: This study investigated the claims of traditional practitioners in the use of Anthocleista djalonensis for the treatment of various diseases and infections in Benue State, Nigeria. The leaves of the plant were collected; air dried; pulverized and successively extracted using hexane, ethyl acetate, ethanol and methanol by microwave assisted method. ...
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