Journal of Drug Design and Medicinal Chemistry

Archive

Volume 7, Issue 2, June 2021

  • Identification of APOE4 Modulators, Targeted Therapeutic Candidates in Coronary Artery Disease, Using Molecular Docking Studies

    Lima Hazarika, Supriyo Sen, Akshaykumar Zawar, Jitesh Doshi

    Issue: Volume 7, Issue 2, June 2021
    Pages: 27-38
    Received: 23 March 2021
    Accepted: 7 April 2021
    Published: 20 April 2021
    DOI: 10.11648/j.jddmc.20210702.11
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    Abstract: Investigate the protein–ligand binding affinity and evaluate the receptor binding abilities of different classes of ligands for APOE4 through molecular docking studies. The polymorphic nature of human Apo E gene encodes one of 3 common epsilon (ε) alleles (ε2, ε3, and ε4), reported to influence the risk of cardiovascular diseases. Structural basis ... Show More
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  • Establishment of a Method to Allow Microbial Limit Testing of Iodine-containing Preparations

    Huang Minna, Tan Fangming, Lin Shaozhu, Liang Zhuanzhi, Qiu Suishan, He Xiaomin

    Issue: Volume 7, Issue 2, June 2021
    Pages: 39-43
    Received: 22 April 2021
    Accepted: 17 May 2021
    Published: 26 May 2021
    DOI: 10.11648/j.jddmc.20210702.12
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    Abstract: Background: Contamination of pharmaceuticals with microorganisms may lead to deleterious effects on the therapeutic properties of the drug, and may potentially cause injuries to intended recipients. Iodine can inhibit and kill microorganisms in pharmaceutical preparations. The risk of microbial contamination of cellular products can be reduced when... Show More
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