Journal of Drug Design and Medicinal Chemistry

Archive

Volume 5, Issue 3, September 2019

  • New ACE Inhibitor Designed from Nicotianamine and Its Docking Pose Prediction Using the Gold Program

    Noboru Takada, Takaharu Okada, Eri Kogawa, Yohsuke Sanada, Ayumi Ishidoya

    Issue: Volume 5, Issue 3, September 2019
    Pages: 33-39
    Received: 16 July 2019
    Accepted: 7 August 2019
    Published: 23 August 2019
    DOI: 10.11648/j.jddmc.20190503.11
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    Abstract: Hypertension is currently one of the most serious health issues worldwide. Nicotianamine, a non-peptide-type amino acid trimer, is ubiquitously present in higher plants and plays a role as an internal metal transporter. It is known that nicotianamine inhibits ACE activity and that oral treatment with the compound improves hypertension. However the ... Show More
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  • Rational Computational Study for New Kinase Inhibitors

    Joao Eustaquio Antunes, Michelle Bueno de Moura Pereira

    Issue: Volume 5, Issue 3, September 2019
    Pages: 40-46
    Received: 25 June 2019
    Accepted: 6 August 2019
    Published: 2 September 2019
    DOI: 10.11648/j.jddmc.20190503.12
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    Abstract: The development of new drugs can present several problems, it is a important obstacle the ability to adapt a molecule that is a potent pharmacological inhibitor and that is also possible to execute its synthesis. Quinazolines are known to be capable of inhibiting kinases. Thus, a detailed study was carried out to propose new quinazolines with alrea... Show More
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