Journal of Drug Design and Medicinal Chemistry

Archive

Volume 2, Issue 6, December 2016

  • In Vivo Antiplasmodial Activity of Fractions and Chromatographic Sub Fractionions of Ethanol Extract of Clerodendrum Myricoides Leaves

    Gebremichael Gebretsadik, Yalemtsehay Mekonnen

    Issue: Volume 2, Issue 6, December 2016
    Pages: 60-64
    Received: 2 June 2016
    Accepted: 15 July 2016
    Published: 3 November 2016
    DOI: 10.11648/j.jddmc.20160206.11
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    Abstract: Herbal medicine preparations from medicinal plants to treat malaria are potential source of new anti-malarial drug development. The objective of this study was to evaluate antiplasmodial activity of fractions and sub fractions of the ethanol extract of Clerodendrum myricoides leaves using 4-day suppressive test against Plasmodium berghei in Swiss a... Show More
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  • Development and Validation of Alternative Analytical Method for Determination of Related Substances of Benzydamine Hydrochloride in Oral Spray by HPLC

    Vasyl A. Cherniy, Svitlana N. Gureeva, Victoriya A. Georgiyants

    Issue: Volume 2, Issue 6, December 2016
    Pages: 65-73
    Received: 20 October 2016
    Accepted: 10 November 2016
    Published: 10 January 2017
    DOI: 10.11648/j.jddmc.20160206.12
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    Abstract: The aim of the present study was to develop and validate HPLC method for determination of related substances of benzydamine hydrochloride in a dosage form, containing benzydamine hydrochloride as an active substance. A new selective, specific and sensitive method was developed for determination of benzydamine degradation products in the formulation... Show More
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  • Validation of Soothing Compounding Mixture Technological Process Preparation

    Lesia Savchenko, Victoriya Georgiyants

    Issue: Volume 2, Issue 6, December 2016
    Pages: 74-78
    Received: 31 October 2016
    Accepted: 26 November 2016
    Published: 11 January 2017
    DOI: 10.11648/j.jddmc.20160206.13
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    Abstract: Validation of soothing compounding mixturetechnological process preparation in accordance with the requirements of the quality system organization was done. It is preparingserially in many pharmacies of Ukraine. Obtained results indicate conformity of the finished medicine quality with the regulatory framework requirements of Ukraine in regard to t... Show More
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