In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days.
| Published in | Journal of Drug Design and Medicinal Chemistry (Volume 3, Issue 5) |
| DOI | 10.11648/j.jddmc.20170305.11 |
| Page(s) | 67-70 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Diclofenac Sodium, Dried Aluminium Hydroxide Gel, Magnesium Trisilicate, Organoleptic Property and Combination Tablets
| [1] | Insel, P. A. (1996). In: Goodman & Gilman’s The Pharmacological Basis of Therapeutics (Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W. and Gilman, A. G., Eds.), McGraw –Hill, New York. pp 618, 637. |
| [2] | Shahidi, R. U. (2015). In: QUIMP-17. Katabon Central Mosque Campus, Dhaka. pp. 334, 338, 561-562. |
| [3] | Robert, B. F. (2005). In: Remington-The Science and Practice of Pharmacy (Henrickson, R., Ed.), Lippincott Williams and Wilkins, Philadelphia. Chapter 83, Analgesic, Antipyretic and Anti-inflammoatory drugs. pp. 1536. |
| [4] | Bangladesh Beaurue of Statistics (2003). Statistical Pocket book – Bangladesh. pp. 367-369 |
| [5] | Pfaffenrath, V and Scherzer, S. (1995). Analgesics and NSAIDs in the treatment of acute migraine attack. Cephalalgia. Suppl 15, 14-20. |
| [6] | Terhagg, B., Hoffman, A., Barkworth, M and Vens, C. B. (2000). Bioavailability of a new effervescent tablet of diclofenac. Int J Clin Pharmacol Ther. 38, 546–551. |
| [7] | Banker, G. B and Anderson, N. R. (1987). In: The Theory and Practice of Industrial Pharmacy (Lachmann, L., Lieberman, H. A. and Kanig, J. L., Eds.), Lea and Febiger, Philadelphia, Chapter 11, Tablets, pp. 293-294, 296, 299, 311-314, 320, 343. |
| [8] | Aulton, M. E. (2013). Aulton’s Pharmaceutics. The design and manufacture of medicines Churchill, Livingstone, Edinburgh. Chapter 12, Powder flow, pp. 194, 195 |
| [9] | Enever, R. P. (2004). In: Bentley’s Textbook of Pharmaceutics (Rawlin, E. A., Ed.), Bailliere Tindall, London. Chapter 10, Drug stability, pp. 140-142, 146-147. |
| [10] | Talman, F. A. J. (2004). In: Bentley’s Textbook of Pharmaceutics (Rawlin, E. A., Ed.), Bailliere Tindall, London. Chapter 19, Tablets and Capsules, pp. 275. |
| [11] | Travers, D. N. (1986). In: Cooper and Gunn’s Tutorial Pharmacy (Carter, S. J., Ed.), Chaper 19, Powder flow and Compaction. pp 222-223. |
| [12] | Allen, L. V (jr)., Popovich, N. G. and Ansel, H. C. (2011). Ansel’s Pharmaceutical Dosageforms and Drug delivery system. Lippincott Williams and Wilkins, Philadelphia. Chapter 8, Tablets, pp. 233, 236, 238-239 |
| [13] | British Pharmacopoiea (1988). pp 893, 895. |
| [14] | Bolton, S. (1987). In: The Theory and Practice of Industrial Pharmacy (Lachmann, L., Lieberman, H. A. and Kanig, J. L., Eds.), Lea and Febiger, Philadelphia, Chapter 10, Statistical applications in the pharmaceutical sciences. pp. 266. |
| [15] | Shargel, L and Yu, A. B. C. (1993). In: Applied Biopharmaceutics and Pharmacokinetics. Chapter 8. Biopharmaceutic consideration in drug product design. Prentice Hall International Inc. USA. pp. 137-140, 151-152. |
| [16] | The United States Pharmacopeia XX/ National Formulary XV. (1982). Supplement 3. U.S. Pharmacopeial Convention, Rockville, MD. pp 310. |
APA Style
Jannatul Fardous, Faria Farzana Perveen, Md Zahidul Islam, A. H. M. Saifuddin, Sakina Sultana. (2017). Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture. Journal of Drug Design and Medicinal Chemistry, 3(5), 67-70. https://doi.org/10.11648/j.jddmc.20170305.11
ACS Style
Jannatul Fardous; Faria Farzana Perveen; Md Zahidul Islam; A. H. M. Saifuddin; Sakina Sultana. Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture. J. Drug Des. Med. Chem. 2017, 3(5), 67-70. doi: 10.11648/j.jddmc.20170305.11
AMA Style
Jannatul Fardous, Faria Farzana Perveen, Md Zahidul Islam, A. H. M. Saifuddin, Sakina Sultana. Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture. J Drug Des Med Chem. 2017;3(5):67-70. doi: 10.11648/j.jddmc.20170305.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.jddmc.20170305.11,
author = {Jannatul Fardous and Faria Farzana Perveen and Md Zahidul Islam and A. H. M. Saifuddin and Sakina Sultana},
title = {Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture},
journal = {Journal of Drug Design and Medicinal Chemistry},
volume = {3},
number = {5},
pages = {67-70},
doi = {10.11648/j.jddmc.20170305.11},
url = {https://doi.org/10.11648/j.jddmc.20170305.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20170305.11},
abstract = {In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days.},
year = {2017}
}
TY - JOUR T1 - Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture AU - Jannatul Fardous AU - Faria Farzana Perveen AU - Md Zahidul Islam AU - A. H. M. Saifuddin AU - Sakina Sultana Y1 - 2017/10/31 PY - 2017 N1 - https://doi.org/10.11648/j.jddmc.20170305.11 DO - 10.11648/j.jddmc.20170305.11 T2 - Journal of Drug Design and Medicinal Chemistry JF - Journal of Drug Design and Medicinal Chemistry JO - Journal of Drug Design and Medicinal Chemistry SP - 67 EP - 70 PB - Science Publishing Group SN - 2472-3576 UR - https://doi.org/10.11648/j.jddmc.20170305.11 AB - In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days. VL - 3 IS - 5 ER -
Information
Email: