Archive:: Journal of Drug Design and Medicinal Chemistry:: Science Publishing Group

Volume 2, Issue 4, August 2016

Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents

Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, Rabia Naz, Muhammad Kamran Rauf, Saima Hayat

Issue: Volume 2, Issue 4, August 2016

Pages: 35-39

Received: 29 February 2016

Accepted: 29 March 2016

Published: 1 August 2016

DOI: 10.11648/j.jddmc.20160204.11

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Abstract: A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (¹H and ¹³C) NMR and FTIR spectroscopy. The newly synthesized co... Show More

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Synthesis and Biological Evaluation of 3-Aryl Pyrazoles as CDK2/HDAC Inhibitor for Anticancer Agents

Xianfeng Huang, Bei Yang, Yuanyuan Liu, Cheng Zhang, Guoqiang Song

Issue: Volume 2, Issue 4, August 2016

Pages: 40-46

Received: 17 May 2016

Accepted: 20 June 2016

Published: 1 August 2016

DOI: 10.11648/j.jddmc.20160204.12

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Abstract: A novel series of pyrazole derivatives containing hydroxamic acid group were designed and synthesized as multi-target inhibitors targeting CDK2 (cyclin-dependent kinases 2) and HDAC (histone deacetylase). Compounds 6e and 6f exhibited most potent CDK2 inhibition as well as HDAC inhibition. In vitro antiproliferative assay indicated that several com... Show More

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