Archive:: Journal of Drug Design and Medicinal Chemistry:: Science Publishing Group

Volume 10, Issue 2, June 2024

Research Article
Homology Modelling and Molecular Docking Studies to Discover Potent Inhibitors of CD169 in PRRSV Infection

Nsabimana Eliphaz, Wen-qiang Cui, Han Xiao, God’spower Bello-Onaghise, Tang Yang, Yu Fei, Zhang Yue Feng, Jun-jie Qin, Wen-xin Guo, Yan-hua Li^*

Issue: Volume 10, Issue 2, June 2024

Pages: 45-53

Received: 14 June 2024

Accepted: 16 July 2024

Published: 6 August 2024

DOI: 10.11648/j.jddmc.20241002.11

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Abstract: CD169 is one of the putative receptors of porcine reproductive and respiratory syndrome virus, also plays a major role in PRRSV infection. Computational methods including, homology modelling, molecular docking analysis and molecular dynamics simulations carried out to investigate 3D structure and potent inhibitors of CD16. Homology modelling and mo... Show More

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Research Article
Synthesis, Biological Evaluation and Molecular Docking Studies of Benzimidazole Derivatives Substitutes as New Antimicrobial Agents

Sonal Bansal^*, Rishabh Gaur, Harsh Bhardwaj, Nitin Kumar, Gyanendra Kumar Sharma, Shashank Shekher Mishra

Issue: Volume 10, Issue 2, June 2024

Pages: 54-66

Received: 9 July 2024

Accepted: 5 August 2024

Published: 20 August 2024

DOI: 10.11648/j.jddmc.20241002.12

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Abstract: Benzimidazole derivatives have assumed an imperative moiety in the hypothetical improvement in heterocyclic science and furthermore utilized broadly in organic synthesis. The synthesis, structure and biological activities of benzimidazole derivatives have been focal point of research enthusiasm for the field of medication because of potential exerc... Show More

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