Synthesis of 2-Amino-5-(3-chloropropyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (Bischlorinated Deazaguanine)
Issue:
Volume 3, Issue 1, February 2017
Pages:
1-4
Received:
9 January 2017
Accepted:
25 January 2017
Published:
18 February 2017
Abstract: There are many forms of DNA damage which may arise from the modifications DNA bases. Deazaguanine is a modified DNA base which is recognised by DNA repair enzyme, Methylguanine DNA-methyltranferase (MGMT). The synthesis of Bischlorinated deazaguanine was successfully carried out via two different routes. The first route was achieved through the reaction of pyrrolopyrimidine with benzyl(triethyl)ammonium chloride, dry dimethylaniline and freshly distilled phosphoryl chloride in acetonitrile under argon atmosphere. An alternative method was employed toward achieving the Bischolorinated through the debenzoylation of the protected pyrrolopyrimidine with 1 M NaOH at 50°C for 1h followed by double chlorination reaction using phosphoryl chloride alone at 80°C for 1h. Both routes were found to be successful with lower impurities recorded from the second route though it gives a low yield but it was shorter.
Abstract: There are many forms of DNA damage which may arise from the modifications DNA bases. Deazaguanine is a modified DNA base which is recognised by DNA repair enzyme, Methylguanine DNA-methyltranferase (MGMT). The synthesis of Bischlorinated deazaguanine was successfully carried out via two different routes. The first route was achieved through the rea...
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Evaluation of Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect®)
Mahendra Kumar Trivedi,
Alice Branton,
Dahryn Trivedi,
Gopal Nayak,
Alan Joseph Balmer,
Dimitrius Anagnos,
Janice Patricia Kinney,
Joni Marie Holling,
Joy Angevin Balmer,
Lauree Ann Duprey-Reed,
Vaibhav Rajan Parulkar,
Parthasarathi Panda,
Kalyan Kumar Sethi,
Snehasis Jana
Issue:
Volume 3, Issue 1, February 2017
Pages:
5-17
Received:
31 January 2017
Accepted:
22 February 2017
Published:
14 March 2017
Abstract: Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control, while another part was treated with The Trivedi Effect® - Energy of Consciousness Healing Treatment remotely by seven renowned Biofield Energy Healers and defined as the Biofield Energy Treated sample. The PXRD analysis exhibited significant alteration of the crystal morphology of the treated sample compared with the control sample. The crystallite size of the treated sample was remarkably changed from range -69.99% to 71.40% compared with the control sample. The average crystallite size was significantly decreased in the treated sample by 13.61% compared with the control sample. Particle size analysis revealed that the particle size in the treated sample at d10, d50, and d90 value was significantly decreased by 5.19%, 26.77%, and 18.22%, respectively compared with the control sample. The treated sample’s surface area was significantly enhanced (12.82%) compared with the control sample. The FT-IR and UV-vis analysis showed that the structure of the magnesium gluconate remained the same in both the treated and control samples. The TGA analysis revealed the four steps thermal degradation of the both samples and the total weight loss of the Biofield Energy Treated sample was increased by 0.55% compared with the control sample. The DSC analysis revealed that the melting temperature of the treated sample (171.72°C) was increased by 0.21% compared with the control sample (171.36°C). The latent heat of fusion was increased by 4.66% in the treated sample compared with the control sample. This result indicated that the thermal stability of treated sample was improved compared with the control sample. The current study infers that The Trivedi Effect® - Biofield Energy Healing might lead to a new polymorphic form of magnesium gluconate, which would be more soluble, bioavailable, and thermally stable compared with the untreated compound. Hence, the treated magnesium gluconate would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic responses against inflammatory diseases, immunological disorders, stress, aging and other chronic infections.
Abstract: Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the physicoc...
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