Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents

Rukhsana Gul; Zainab Nawaz; Amin Badshah; Azim Khan; Asif Junaid; Rabia Naz; Muhammad Kamran Rauf; Saima Hayat

doi:doi:10.11648/j.jddmc.20160204.11

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Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents

Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, Rabia Naz, Muhammad Kamran Rauf, Saima Hayat

Published in Journal of Drug Design and Medicinal Chemistry (Volume 2, Issue 4)

Received: 29 February 2016 Accepted: 29 March 2016 Published: 1 August 2016

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Abstract

A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (¹H and ¹³C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.

Published in	Journal of Drug Design and Medicinal Chemistry (Volume 2, Issue 4)
DOI	10.11648/j.jddmc.20160204.11
Page(s)	35-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Synthesis, Antifungal Activity, Antibacterial Activity

References

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[13]	Brzozowski, Z. European Journal of Medicinal Chemistry, 2002, 37, 285-293.
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[19]	Gul R, Altaf A. A, Khan A, Badshah A, Shah A, Rehman ZU, Naz R, Tahir MN, Junaid A. Biologically Active New N, N', N''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization. Medicinal Chemistry. 2016 Jan 28 [Epub ahead of print].
[20]	Gul, R. Rauf, M. K. Badshah, A. Azam, S. S. Tahir, M. N. Khan, A. European Journal of Medicinal Chemistry, 2014, 85, 438-449.

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APA Style

Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, et al. (2016). Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. Journal of Drug Design and Medicinal Chemistry, 2(4), 35-39. https://doi.org/10.11648/j.jddmc.20160204.11

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ACS Style

Rukhsana Gul; Zainab Nawaz; Amin Badshah; Azim Khan; Asif Junaid, et al. Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. J. Drug Des. Med. Chem. 2016, 2(4), 35-39. doi: 10.11648/j.jddmc.20160204.11

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AMA Style

Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, et al. Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. J Drug Des Med Chem. 2016;2(4):35-39. doi: 10.11648/j.jddmc.20160204.11

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@article{10.11648/j.jddmc.20160204.11,
  author = {Rukhsana Gul and Zainab Nawaz and Amin Badshah and Azim Khan and Asif Junaid and Rabia Naz and Muhammad Kamran Rauf and Saima Hayat},
  title = {Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {2},
  number = {4},
  pages = {35-39},
  doi = {10.11648/j.jddmc.20160204.11},
  url = {https://doi.org/10.11648/j.jddmc.20160204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20160204.11},
  abstract = {A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.},
 year = {2016}
}

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TY  - JOUR
T1  - Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents
AU  - Rukhsana Gul
AU  - Zainab Nawaz
AU  - Amin Badshah
AU  - Azim Khan
AU  - Asif Junaid
AU  - Rabia Naz
AU  - Muhammad Kamran Rauf
AU  - Saima Hayat
Y1  - 2016/08/01
PY  - 2016
N1  - https://doi.org/10.11648/j.jddmc.20160204.11
DO  - 10.11648/j.jddmc.20160204.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 35
EP  - 39
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20160204.11
AB  - A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.
VL  - 2
IS  - 4
ER  -

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Author Information

Rukhsana Gul

Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan
Zainab Nawaz

Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan
Amin Badshah

Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
Azim Khan

Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan
Asif Junaid

Department of Microbiology, Kohat University of Science and Technology, Kohat, Pakistan
Rabia Naz

Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan
Muhammad Kamran Rauf

Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan
Saima Hayat

Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan

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APA Style

Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, et al. (2016). Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. Journal of Drug Design and Medicinal Chemistry, 2(4), 35-39. https://doi.org/10.11648/j.jddmc.20160204.11

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ACS Style

Rukhsana Gul; Zainab Nawaz; Amin Badshah; Azim Khan; Asif Junaid, et al. Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. J. Drug Des. Med. Chem. 2016, 2(4), 35-39. doi: 10.11648/j.jddmc.20160204.11

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AMA Style

Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, et al. Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. J Drug Des Med Chem. 2016;2(4):35-39. doi: 10.11648/j.jddmc.20160204.11

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@article{10.11648/j.jddmc.20160204.11,
  author = {Rukhsana Gul and Zainab Nawaz and Amin Badshah and Azim Khan and Asif Junaid and Rabia Naz and Muhammad Kamran Rauf and Saima Hayat},
  title = {Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {2},
  number = {4},
  pages = {35-39},
  doi = {10.11648/j.jddmc.20160204.11},
  url = {https://doi.org/10.11648/j.jddmc.20160204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20160204.11},
  abstract = {A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.},
 year = {2016}
}

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TY  - JOUR
T1  - Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents
AU  - Rukhsana Gul
AU  - Zainab Nawaz
AU  - Amin Badshah
AU  - Azim Khan
AU  - Asif Junaid
AU  - Rabia Naz
AU  - Muhammad Kamran Rauf
AU  - Saima Hayat
Y1  - 2016/08/01
PY  - 2016
N1  - https://doi.org/10.11648/j.jddmc.20160204.11
DO  - 10.11648/j.jddmc.20160204.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 35
EP  - 39
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20160204.11
AB  - A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.
VL  - 2
IS  - 4
ER  -

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