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Optimal Combination of Doses for Isoniazid and Vitamin B6 to Treat Tuberculosis Destructive Guinea Pigs
Ludmila Gayova,
Vasil Petrenko,
Yulia Kuharivska,
Serhiy Baran
Issue:
Volume 1, Issue 1, December 2017
Pages:
1-4
Received:
28 October 2017
Accepted:
14 November 2017
Published:
1 December 2017
DOI:
10.11648/j.ijast.20170101.11
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Abstract: This paper presents the results of morphological studies of tuberculosis and nonspecific inflammatory changes of the guinea pigs in the treatment of different ratios of isoniazid with pyridoxine hydrochloride. The optimal dose ratio of the expression of specific and non-specific manifestations of inflammation in the lungs, liver, kidneys and spleen. Also prayed to interpret the results of studies for the treatment of destructive tuberculosis in humans. It was proposed a method of determining the optimum ratio of doses of the most pronounced therapeutic effect and minimal side effects. The aim of the study was to conduct morphological evaluation of lesions of internal organs (lungs, liver, kidneys, spleen) after treatment of experimental tuberculosis of guinea pigs different ratios of doses of isoniazid and pyridoxine hydrochloride. The optimal therapeutic effect is obtained by treating animals with experimental tuberculosis isoniazid at a dose of 26 mg/kg of vitamin B6 and 10mg/kg body weight of the animal, thus completely disappeared phenomenon specific inflammation in the lungs, liver, kidneys and spleen. This phenomenon also disappeared perifocal nonspecific inflammation. Disappeared dystrophic and necrotic changes in the studied organs.
Abstract: This paper presents the results of morphological studies of tuberculosis and nonspecific inflammatory changes of the guinea pigs in the treatment of different ratios of isoniazid with pyridoxine hydrochloride. The optimal dose ratio of the expression of specific and non-specific manifestations of inflammation in the lungs, liver, kidneys and spleen...
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The Amphibolous Role of miR-203 in Gastrointestinal and Urogenital Cancers
Issue:
Volume 1, Issue 1, December 2017
Pages:
5-14
Received:
30 October 2017
Accepted:
16 November 2017
Published:
3 January 2018
DOI:
10.11648/j.ijast.20170101.12
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Abstract: miR-203, as a member of the miRNAs family, play a major role in control of gene expression during normal development and are disrupted in the initiation and progression of specific diseases. It was worth nothing that a growing body of evidence indicated an abnormal expression of miR-203 in several human leading cancers including gastrointestinal and urogenital cancers. The cytosine-phosphoguanine (CpG)-island methylation was one of the most significant factors which controlled the expression of miR-203. Furthermore, miR-203 participated in these cancers via targeting its downstream genes. However, the precise regulatory mechanisms underlying miR-203 association with these cancers are still not fully understood. The aim of this review is to sum up the collective knowledge of miR-203 in gastrointestinal and urogenital cancers.
Abstract: miR-203, as a member of the miRNAs family, play a major role in control of gene expression during normal development and are disrupted in the initiation and progression of specific diseases. It was worth nothing that a growing body of evidence indicated an abnormal expression of miR-203 in several human leading cancers including gastrointestinal an...
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Identification of Staphylococcus Aureus and Profile of Oxacillin Resistance in Hospital Environmental Ants
Melissa Costa Martins,
José Dionísio de Paula Júnior
Issue:
Volume 1, Issue 1, December 2017
Pages:
15-18
Received:
19 November 2017
Accepted:
29 November 2017
Published:
3 January 2018
DOI:
10.11648/j.ijast.20170101.13
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Abstract: The objective of the research is to identify the presence of Staphylococcus aureus in hospital ants and describe its resistance profile relative to oxacillin. Methods: This is an analytical cross with temporality. The research scenario consisted of a charity hospital and later the microbiology laboratory of the Faculty President Antonio Carlos. The sample consists of five ants explored each sector, namely ICU and Surgical Center, totaling 10 ants. Results: Of the total samples, 7 (70%) ants grew Staphylococcus aureus and 3 (30%) did not. Of the samples collected in each sector 3 (60%) in the ICC, and 4 (80%), surgical center, showed growth of Staphylococcus aureus. These strains of S. aureus found 100% sensitivity showed a profile of oxacillin-resistant. Conclusion: It is concluded from the results obtained in the present study that ants allocated in hospitals may carry Staphylococcus aureus. As well as this bacterial species can exhibit antibiotic resistance, as shown Staphylococcus aureus and oxacillin resistant.
Abstract: The objective of the research is to identify the presence of Staphylococcus aureus in hospital ants and describe its resistance profile relative to oxacillin. Methods: This is an analytical cross with temporality. The research scenario consisted of a charity hospital and later the microbiology laboratory of the Faculty President Antonio Carlos. The...
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Effects of GnRH on Conception Rate at the Time of Artificial Insemination in Crossbred Dairy Cows
Sm. Ahasanul Hamid,
S. M. Kamruzzaman
Issue:
Volume 1, Issue 1, December 2017
Pages:
19-34
Received:
20 November 2017
Accepted:
7 December 2017
Published:
3 January 2018
DOI:
10.11648/j.ijast.20170101.14
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Abstract: The present study was conducted to investigate the influence of GnRH (Gonadotropin Releasing Hormone) administration on conception rate at the time of artificial insemination (AI) in healthy crossbred dairy cows. A total 90 cows were recruited and a preset questionnaire was answered by the owners. The cows were divided randomly in to two equal groups. GnRH treated group was injected intramuscularly (i/m) in the neck muscle with GnRH (Gonadorelin Acetate) at the time of AI. Again the treated group was divided randomly into three equal groups (15 cows each) for three different doses of GnRH (200, 250, 300 µg). The necessary information was taken from the owner with pretested questionnaire. The overall 71.11% conception rate was found in GnRH treated group on the other hands 55.56% conception rate was in control groups and having significant effect (P<0.05). There were significant effect (P<0.05) of age and milk yield and there were no significant effect of doses, timing, body condition score and parity within GnRH treated group. The study revealed that use of GnRH improved the conception rate in crossbred dairy cows at the time of AI.
Abstract: The present study was conducted to investigate the influence of GnRH (Gonadotropin Releasing Hormone) administration on conception rate at the time of artificial insemination (AI) in healthy crossbred dairy cows. A total 90 cows were recruited and a preset questionnaire was answered by the owners. The cows were divided randomly in to two equal grou...
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A Study of the Prevalence and Abundance of Chewing Lice (Phthiraptera) in Selected Poultry Farms in Benin City, Edo State
Opoggen Love,
Rotimi Johnny,
Igbojiaku Chukwuemeka Valentine
Issue:
Volume 1, Issue 1, December 2017
Pages:
35-42
Received:
23 November 2017
Accepted:
9 December 2017
Published:
10 January 2018
DOI:
10.11648/j.ijast.20170101.15
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Abstract: An investigation on the prevalence of chewing lice in three selected poultries located in Ekosodin, EDPA and Adolor in Benin metropolis in Edo state was conducted fortnightly from March to April, 2016 to determine the chewing lice species richness, lice abundance, composition, sex ratio and percent prevalence. Menocanthus stramineus, Menopon gallinae and Lipeurus caponis were the only chewing lice species recorded. The largest population of chewing lice species occurred in Adolor and least in EDPA. The most prevalent species across the three localities was M. stramineus with a mean prevalence of (56%), followed by M. gallinae (34%) and L. caponis (10%). Statistical analysis showed that the abundance of M. stramineus significantly differed among locations; Ekosodin, Adolor and EDPA (F2,23 =42.18; P <.001) and between sexes with females being more abundant. (F1,23 =9.44; P =0.007) while M. gallinae differed significantly among the different locations but did not differ in sexes unlike L. caponis that did not differ significantly both in location (F2,23 =0.66; P =0.528) and between sex (F1,23 =0.05; P =0.824) with females being more abundant in all. Therefore, further studies to access the impact of these lice species on the health and production performance including cost effectiveness of control strategies and thorough education of poultry managers are strongly recommended.
Abstract: An investigation on the prevalence of chewing lice in three selected poultries located in Ekosodin, EDPA and Adolor in Benin metropolis in Edo state was conducted fortnightly from March to April, 2016 to determine the chewing lice species richness, lice abundance, composition, sex ratio and percent prevalence. Menocanthus stramineus, Menopon gallin...
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