This paper presents the results of morphological studies of tuberculosis and nonspecific inflammatory changes of the guinea pigs in the treatment of different ratios of isoniazid with pyridoxine hydrochloride. The optimal dose ratio of the expression of specific and non-specific manifestations of inflammation in the lungs, liver, kidneys and spleen. Also prayed to interpret the results of studies for the treatment of destructive tuberculosis in humans. It was proposed a method of determining the optimum ratio of doses of the most pronounced therapeutic effect and minimal side effects. The aim of the study was to conduct morphological evaluation of lesions of internal organs (lungs, liver, kidneys, spleen) after treatment of experimental tuberculosis of guinea pigs different ratios of doses of isoniazid and pyridoxine hydrochloride. The optimal therapeutic effect is obtained by treating animals with experimental tuberculosis isoniazid at a dose of 26 mg/kg of vitamin B6 and 10mg/kg body weight of the animal, thus completely disappeared phenomenon specific inflammation in the lungs, liver, kidneys and spleen. This phenomenon also disappeared perifocal nonspecific inflammation. Disappeared dystrophic and necrotic changes in the studied organs.
| Published in | International Journal of Animal Science and Technology (Volume 1, Issue 1) |
| DOI | 10.11648/j.ijast.20170101.11 |
| Page(s) | 1-4 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Tuberculosis, Experimental Model, Guinea Pigs, Isoniazid, Vitamin B6, Optimal Ratio
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APA Style
Ludmila Gayova, Vasil Petrenko, Yulia Kuharivska, Serhiy Baran. (2017). Optimal Combination of Doses for Isoniazid and Vitamin B6 to Treat Tuberculosis Destructive Guinea Pigs. International Journal of Animal Science and Technology, 1(1), 1-4. https://doi.org/10.11648/j.ijast.20170101.11
ACS Style
Ludmila Gayova; Vasil Petrenko; Yulia Kuharivska; Serhiy Baran. Optimal Combination of Doses for Isoniazid and Vitamin B6 to Treat Tuberculosis Destructive Guinea Pigs. Int. J. Anim. Sci. Technol. 2017, 1(1), 1-4. doi: 10.11648/j.ijast.20170101.11
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Download@article{10.11648/j.ijast.20170101.11,
author = {Ludmila Gayova and Vasil Petrenko and Yulia Kuharivska and Serhiy Baran},
title = {Optimal Combination of Doses for Isoniazid and Vitamin B6 to Treat Tuberculosis Destructive Guinea Pigs},
journal = {International Journal of Animal Science and Technology},
volume = {1},
number = {1},
pages = {1-4},
doi = {10.11648/j.ijast.20170101.11},
url = {https://doi.org/10.11648/j.ijast.20170101.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20170101.11},
abstract = {This paper presents the results of morphological studies of tuberculosis and nonspecific inflammatory changes of the guinea pigs in the treatment of different ratios of isoniazid with pyridoxine hydrochloride. The optimal dose ratio of the expression of specific and non-specific manifestations of inflammation in the lungs, liver, kidneys and spleen. Also prayed to interpret the results of studies for the treatment of destructive tuberculosis in humans. It was proposed a method of determining the optimum ratio of doses of the most pronounced therapeutic effect and minimal side effects. The aim of the study was to conduct morphological evaluation of lesions of internal organs (lungs, liver, kidneys, spleen) after treatment of experimental tuberculosis of guinea pigs different ratios of doses of isoniazid and pyridoxine hydrochloride. The optimal therapeutic effect is obtained by treating animals with experimental tuberculosis isoniazid at a dose of 26 mg/kg of vitamin B6 and 10mg/kg body weight of the animal, thus completely disappeared phenomenon specific inflammation in the lungs, liver, kidneys and spleen. This phenomenon also disappeared perifocal nonspecific inflammation. Disappeared dystrophic and necrotic changes in the studied organs.},
year = {2017}
}
TY - JOUR T1 - Optimal Combination of Doses for Isoniazid and Vitamin B6 to Treat Tuberculosis Destructive Guinea Pigs AU - Ludmila Gayova AU - Vasil Petrenko AU - Yulia Kuharivska AU - Serhiy Baran Y1 - 2017/12/01 PY - 2017 N1 - https://doi.org/10.11648/j.ijast.20170101.11 DO - 10.11648/j.ijast.20170101.11 T2 - International Journal of Animal Science and Technology JF - International Journal of Animal Science and Technology JO - International Journal of Animal Science and Technology SP - 1 EP - 4 PB - Science Publishing Group SN - 2640-1312 UR - https://doi.org/10.11648/j.ijast.20170101.11 AB - This paper presents the results of morphological studies of tuberculosis and nonspecific inflammatory changes of the guinea pigs in the treatment of different ratios of isoniazid with pyridoxine hydrochloride. The optimal dose ratio of the expression of specific and non-specific manifestations of inflammation in the lungs, liver, kidneys and spleen. Also prayed to interpret the results of studies for the treatment of destructive tuberculosis in humans. It was proposed a method of determining the optimum ratio of doses of the most pronounced therapeutic effect and minimal side effects. The aim of the study was to conduct morphological evaluation of lesions of internal organs (lungs, liver, kidneys, spleen) after treatment of experimental tuberculosis of guinea pigs different ratios of doses of isoniazid and pyridoxine hydrochloride. The optimal therapeutic effect is obtained by treating animals with experimental tuberculosis isoniazid at a dose of 26 mg/kg of vitamin B6 and 10mg/kg body weight of the animal, thus completely disappeared phenomenon specific inflammation in the lungs, liver, kidneys and spleen. This phenomenon also disappeared perifocal nonspecific inflammation. Disappeared dystrophic and necrotic changes in the studied organs. VL - 1 IS - 1 ER -
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