American Journal of Internal Medicine

Archive

Volume 3, Issue 1, January 2015

  • Matrix Metalloproteinase-2 as Potential Marker of Early Nephropathy in Type 1 Diabetes

    Mohamed Fouad, Maher Boraie

    Issue: Volume 3, Issue 1, January 2015
    Pages: 1-5
    Received: 18 January 2015
    Accepted: 29 January 2015
    Published: 6 February 2015
    DOI: 10.11648/j.ajim.20150301.11
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    Abstract: Background: Early detection of diabetic nephropathy (DN) is important. Matrix metalloproteinases-2 (MMP-2) regulates a variety of cellular functions including apoptosis and angiogenesis. Diabetic environment stimulates the secretion of MMP-2 that is considered to participate in DN. Objectives: We conducted this study to investigate the level of MMP... Show More
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  • Adiponectin as a Predictor for the Severity of Sepsis in ICU Patients

    Mohammed Amin Abd-Elghany, Nahed Salah Eldin, Sherif Wadie, Mervat Mohammed El Damarawy, Fady Adib Abd-El-malek, Ashraf Abd El-Khalik Barakat

    Issue: Volume 3, Issue 1, January 2015
    Pages: 6-14
    Received: 25 January 2015
    Accepted: 31 January 2015
    Published: 6 February 2015
    DOI: 10.11648/j.ajim.20150301.12
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    Abstract: Sepsis is widely diagnosed In ICU patients. The sepsis markers are numerous with variable sensitivity and specificity. Adiponectin is a protein hormone that is secreted from adipose tissue into the bloodstream. It is a key substance in metabolic syndrome and has an anti-inflammatory property. The relationship between adiponectin and sepsis is uncle... Show More
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  • Diversity within the Immunodominant Epitopes of Envelope gp41 HIV-1 in Kenya and Its Effects on Performance of the HIV-1 Antibody-Based Detection Kits

    James Kimotho, Zipporah N g’ang’a2, Edna Nyairo, Missiani Ochwoto, Nicholas Nzioka, Francis Ogolla, Michael Kiptoo

    Issue: Volume 3, Issue 1, January 2015
    Pages: 15-22
    Received: 22 January 2015
    Accepted: 2 February 2015
    Published: 10 February 2015
    DOI: 10.11648/j.ajim.20150301.13
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    Abstract: Background: Human Immunodeficiency Virus (HIV) is characterized by high rates of genetic variability in vivo that could affect the performance of the HIV-1 Antibody-Based Detection Kits in use in Kenya. Objective: This study aimed at establishing the diversity of Envelope gp41 Epitopes and its effects on performance of the currently used HIV diagno... Show More
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  • Laboratory Evaluation of the Validity of the Current HIV Testing Algorithm in Kenya

    James Kimotho, Zipporah Ng’ang’a, Edna Nyairo, Missiani Ochwoto, Nicholas Nzioka, Francis Ogolla, Michael Kiptoo

    Issue: Volume 3, Issue 1, January 2015
    Pages: 23-27
    Received: 30 January 2015
    Accepted: 9 February 2015
    Published: 15 February 2015
    DOI: 10.11648/j.ajim.20150301.14
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    Abstract: Background: The HIV Lateral Flow Tests (LFTs) provide a good compromise between accuracy, cost, speed and overall effectiveness. Objective: This study assessed the laboratory performance of the LFTs in the current National HIV Testing Algorithm in Kenya. Methods: Four hundred blood samples, 145 HIV positives and 255 HIV negatives, were collected fr... Show More
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