Abstract: Introduction: Prediabetes confers about a sixfold increased risk of diabetes and a two to threefold increased risk of cardiovascular events. A family history of diabetes is a major risk factor for the development of diabetes. The detection of prediabetes in its early stages in persons at risk could lead to the delay or prevention of the disease and subsequent adverse sequalae. Methods: A total of 180 first-degree relatives (FDR) of patients with type 2 diabetes and 90 controls were assessed. A fasting venous blood sample was collected for fasting plasma glucose. Following 75g of anhydrous glucose ingestion, the 2-hour post glucose load and glycated haemoglobin was assessed. Statistical significance was set at a p value <0.05. Results: The mean age of the cases who were first degree relatives of type 2 DM was 38.2±12.3 years with a female to male ratio of 1.4:1. The prevalence of prediabetes was 23.9% which was significantly higher than in the controls (10%; χ2=8.385, p=0.015). Using the various indices of glycaemic control, impaired fasting glucose, impaired glucose tolerance and elevated HbA1c in the FDR’s was found in 15.0%, 12.2% and 15.6% respectively. Conclusion: Relatives of Type 2 DM patients should be considered as primary target for diabetes preventive programs as this will necessitate institution of effective measures early to delay or prevent the onset of type 2 diabetes mellitus.Abstract: Introduction: Prediabetes confers about a sixfold increased risk of diabetes and a two to threefold increased risk of cardiovascular events. A family history of diabetes is a major risk factor for the development of diabetes. The detection of prediabetes in its early stages in persons at risk could lead to the delay or prevention of the disease and...Show More
Abstract: Rothia Mucilaginosa (RM) is part of the microbiota of the pharynx and upper respiratory tract. RM is a gram-positive, enveloped, coagulase-negative coccus of the family Micrococcaceae. Clinical manifestations range from mild bronchitis to recurrent pneumonia and lung abscess. It is difficult to determine the clinical significance of this organism in respiratory specimens, therefore, in the diagnosis of pneumonia caused by R. mucilaginosa, bronchoscopy specimens should be cultured. Risk factors associated with Rothia are hematologic malignancies and neutropenia. At present, the importance of Rothia in various pathologies remains unclear due to its difficulty in culture and high potential for contamination at the time of sampling. Although it is an oral microbiota, it has been implicated in pneumonia after being identified in sputum or bronchoalveolar lavage smears and in infectious lesions of the respiratory tract, such as lung abscess and empyema. The challenge of MRI infection in clinical practice is deciding whether it is a real infection or a product of sample contamination. We present the case of a 50-year-old adult patient, without neutropenia, without hematological malignancy, with progressive idiopathic pulmonary fibrosis (IPF) of 1 year of evolution. On admission to the hospital, this person presented signs of respiratory failure, tachycardia, upper rales. auscultation and 85% oxygen saturation, that's why he went through many different studies to diagnose Rothia Mucilaginosa pneumonia.Abstract: Rothia Mucilaginosa (RM) is part of the microbiota of the pharynx and upper respiratory tract. RM is a gram-positive, enveloped, coagulase-negative coccus of the family Micrococcaceae. Clinical manifestations range from mild bronchitis to recurrent pneumonia and lung abscess. It is difficult to determine the clinical significance of this organism i...Show More
