Abstract: Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.Abstract: Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confir...Show More
