Pharmaceutical Science and Technology

Archive

Volume 8, Issue 2, December 2024

  • Research Article

    Formulation and Ex Vivo Evaluation of Membrane Permeation Properties of a Mixed Acetaminophen Gel for Rectal Administration

    Dally Laba Ismael*, Aka-Any Grah Sandrine, Baka Ko uassi Wilfried Junior, Anin Apo Laurette Ingrid, Lia Gnahore Jose Arthur

    Issue: Volume 8, Issue 2, December 2024
    Pages: 18-23
    Received: 3 July 2024
    Accepted: 30 July 2024
    Published: 20 August 2024
    DOI: 10.11648/j.pst.20240802.11
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    Abstract: The purpose of this work was to evaluate the permeation of a mixed native starch-based gel of Ipomoea batatas (Convolvulaceae), using acetaminophen as a tracer through a rat rectal membrane (ex vivo method). The formulated gel was composed of a 10 g solution of poloxamer 407 at 20% and 2.5 g of glycerolized potato starch. The gel obtained was a smo... Show More
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  • Research Article

    Formulation and in vitro Evaluation of Liquisolid Compact of Celecoxib

    Ezegbe Chekwube Andrew*, Anikwe Celestine Chidera, Okorie James Ekemezie, Okafor Nnedimma Pauline, Amarachi Grace Ezegbe, Nwankwo Emmanuel Chinedu, Okorafor Ezinne Chinemerem

    Issue: Volume 8, Issue 2, December 2024
    Pages: 24-46
    Received: 9 June 2024
    Accepted: 27 June 2024
    Published: 20 September 2024
    DOI: 10.11648/j.pst.20240802.12
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    Abstract: Introduction: The liquisolid technique presents a promising avenue for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs like celecoxib. This study investigated the formulation and evaluation of celecoxib tablets using this technique. Aim: To formulate and evaluate celecoxib tablets using the liquisolid technique, wit... Show More
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  • Research Article

    Risk Assessment for Environmental Monitoring of the Injectable Cephalosporins and Carbapenems Production Plant

    Xenia Madrazo Sagre*, Susana Gómez Martínez, Nancy Oña Aldama

    Issue: Volume 8, Issue 2, December 2024
    Pages: 47-55
    Received: 19 July 2024
    Accepted: 11 September 2024
    Published: 31 October 2024
    DOI: 10.11648/j.pst.20240802.13
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    Abstract: Introduction: Operations with medicines require compliance with the requirements established in Good Practices with the objective of guaranteeing their quality, safety and effectiveness. The Quality Management System incorporates quality risk management as an integral part. In the injectable plant, the aseptic processing of Cephalosporins and Carba... Show More
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