Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.
| Published in | Pharmaceutical Science and Technology (Volume 6, Issue 2) |
| DOI | 10.11648/j.pst.20220602.12 |
| Page(s) | 26-29 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Agarwood, Recurrent Aphthous Ulcer, Sesquiterpene, Pain, Neurotransmitter
| [1] | Wang Z, Cao H, Xiong J, et al. Recent advances in the aetiology of recurrent aphthous stomatitis (RAS). Postgrad Med J. 2022; 98 (1155): 57-66. |
| [2] | Tan CS, Isa NM, Ismail I, Zainal Z. Agarwood Induction: Current Developments and Future Perspectives. Front Plant Sci. 2019; 10: 122. |
| [3] | Wang Q, Shang LL, Yan TT, et al. HPLC fingerprint characteristics of agarwood from different habitats [J]. Scientia Silvae Sinicae, 2021, 57 (2): 150-159. |
| [4] | Zhang N, Xue S, Song J, et al. Effects of various artificial agarwood-induction techniques on the metabolome of Aquilaria sinensis. BMC Plant Biol. 2021; 21 (1): 591. |
| [5] | Li J, Chen D, Jiang Y, et al. Identification and quantification of 5, 6, 7, 8-tentrahtdro-2- (2-phenylethyl) chromones in Chinese eaglewood by HPLC with diode array detection and MS [J]. J Sep Sci. 2013; 36 (23): 3733-3740. |
| [6] | Al-Maweri SA, Alaizari N, Alanazi RH, et al. Efficacy of hyaluronic acid for recurrent aphthous stomatitis: a systematic review of clinical trials. Clin Oral Investig. 2021; 25 (12): 6561-6570. |
| [7] | Suter VGA, Sjölund S, Bornstein MM. Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review. Lasers Med Sci. 2017; 32 (4): 953-963. |
| [8] | Wang, J., Xu, X., Liang, Y. Comparative study on analgesic effects of different years of Chinese eaglewood. Hainan Med. J. 2014; 5, 2188-2190. |
| [9] | Yan T, Yang S, Chen Y, et al. Chemical Profiles of Cultivated Agarwood Induced by Different Techniques. Molecules. 2019; 24 (10): 1990. |
| [10] | Xiong LY, Ji GX, Lin L, et al. Study on Analgesic Effective Parts and Active Substance of Aquilaria sinensis (Lour.) Gilg. Lishizhen Medicine and Materia Medica Research, 2014; 25 (08): 1842-1844. |
| [11] | Rothan H. A, Paydar M, Mohamad J, et al. Isolation and characterisation of acetylcholinesterase inhibitors from aquilaria subintegra for the treatment of Alzheimer’s disease (AD) Curr. Alzheimer Res. 2014; 11: 206–214. |
| [12] | Takemoto H, Ito M, Shiraki T, et al. Sedative effects of vapor inhalation of agarwood oil and spikenard extract and identification of their active components. J. Nat. Med. 2007; 62: 41–46. |
| [13] | Wang S, Wang C, Peng D, et al. Agarwood essential oil displays sedative-hypnotic effects through the GABAergic system. Molecules. 2017; 22: 2190. |
| [14] | Yi Z, Wang W, Zhang J. Effects of novel anxiolytic 4-butyl-alpha-agarofuran on levels of monoamine neurotransmitters in rats. Eur. J. Pharm. 2004; 504: 39–44. |
| [15] | Huo HX, Zhu ZX, Pang DR, et al. Anti-neuroinflammatory sesquiterpenes from Chinese eaglewood. Fitoterapia. 2015; 106: 115–121. |
| [16] | Yang L, Qiao LR, Zhang JJ, et al. Two new sesquiterpene derivatives from Chinese eaglewood. J Asian Nat Prod Res. 2012; 14 (11): 1054-1058. |
| [17] | Wang Ch, Wang S, Peng DQ, et al. Prediction and Analysis of the Components and Therapeutic Targets of Agarwood Essential Oil. Chin Pharm J, 2019, 54 (23): 1958-1964. |
| [18] | Wang C, Wang Y, Gong B, et al. Effective Components and Molecular Mechanism of Agarwood Essential Oil Inhalation and the Sedative and Hypnotic Effects Based on GC-MS-Qtof and Molecular Docking. Molecules. 2022; 27 (11): 3483. |
APA Style
Si-Yu Tao, Jing-Kai Fu, Sunchuri Diwas, Yi-Nan Zhang, Nan Wang, et al. (2022). Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer. Pharmaceutical Science and Technology, 6(2), 26-29. https://doi.org/10.11648/j.pst.20220602.12
ACS Style
Si-Yu Tao; Jing-Kai Fu; Sunchuri Diwas; Yi-Nan Zhang; Nan Wang, et al. Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer. Pharm. Sci. Technol. 2022, 6(2), 26-29. doi: 10.11648/j.pst.20220602.12
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.pst.20220602.12,
author = {Si-Yu Tao and Jing-Kai Fu and Sunchuri Diwas and Yi-Nan Zhang and Nan Wang and Yao Yao and Fan-Di Xu and Yang Lin and Zhu-Ling Guo},
title = {Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer},
journal = {Pharmaceutical Science and Technology},
volume = {6},
number = {2},
pages = {26-29},
doi = {10.11648/j.pst.20220602.12},
url = {https://doi.org/10.11648/j.pst.20220602.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20220602.12},
abstract = {Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.},
year = {2022}
}
TY - JOUR T1 - Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer AU - Si-Yu Tao AU - Jing-Kai Fu AU - Sunchuri Diwas AU - Yi-Nan Zhang AU - Nan Wang AU - Yao Yao AU - Fan-Di Xu AU - Yang Lin AU - Zhu-Ling Guo Y1 - 2022/11/29 PY - 2022 N1 - https://doi.org/10.11648/j.pst.20220602.12 DO - 10.11648/j.pst.20220602.12 T2 - Pharmaceutical Science and Technology JF - Pharmaceutical Science and Technology JO - Pharmaceutical Science and Technology SP - 26 EP - 29 PB - Science Publishing Group SN - 2640-4540 UR - https://doi.org/10.11648/j.pst.20220602.12 AB - Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU. VL - 6 IS - 2 ER -
Information
Email: