Research Article
Synthesis and Pharmacokinetic Evaluation of Novel Bioactive Organic Compounds
Issue:
Volume 14, Issue 1, February 2026
Pages:
1-7
Received:
24 November 2025
Accepted:
22 January 2026
Published:
26 January 2026
Abstract: The integration of medicinal chemistry with modern computational and in silico approaches enables the scientific re-evaluation of traditional knowledge, particularly highlighting the role of organic bioactives products. This study describes the synthesis and pharmacokinetic profiling of a series of organic compounds of pharmaceutical interest that were designed to act as potential bioactive agents. Synthesis strategies were optimized to improve reaction yields. Comprehensive spectroscopic analyses, including nuclear magnetic resonance analysis of protons and carbon-13 (¹H and ¹³C) and mass spectrometry, were employed to verify the molecular structures and evaluate the purity of the synthesized compounds. The synthesized products were then theoretically evaluated for their pharmacokinetics using standard drug-type tests. The results revealed that products were obtained in the best yields (65-82%) using our validated protocols of synthesis and characterized for their structure. For the theoretical study on their pharmaceuticals assessments, most of the compounds exhibited favorable pharmacokinetic profiles (that satisfied the key criteria of Lipinski, and the Connolly parameters (solubility and stability)), as well as demonstrating a good safety profile. This study highlights the importance of combining optimized synthesis methodologies with computational pharmacokinetic screening as an effective method for the initial design and evaluation of new molecules.
Abstract: The integration of medicinal chemistry with modern computational and in silico approaches enables the scientific re-evaluation of traditional knowledge, particularly highlighting the role of organic bioactives products. This study describes the synthesis and pharmacokinetic profiling of a series of organic compounds of pharmaceutical interest that ...
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Research Article
Synthesis and Characterization of Cadmium Sulphide (CdS) and Cobalt Sulphide (CoS) Heterostructure Using the Chemical Bath Deposition Method
Tangut Masreshaw Eshete*
,
Takele Teshome Somano
Issue:
Volume 14, Issue 1, February 2026
Pages:
8-18
Received:
23 December 2025
Accepted:
16 January 2026
Published:
6 February 2026
DOI:
10.11648/j.ajche.20261401.12
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Abstract: In this study, cadmium Sulphide (CdS), a group II–VI semiconductor known for its wide applications in optoelectronics, piezoelectric devices, and other semiconductor technologies, and cobalt Sulphide (CoS), notable for its roles in solar-selective coatings, infrared sensing, and photo electrochemical energy storage, were investigated. Thin films of CdS, CoS, and their heterostructure (CdS/CoS and CoS/CdS) were synthesized via the chemical bath deposition (CBD) method at 80°C for 1.5 hours, using cadmium acetate, cobalt acetate, thioacetamide, and EDTA as precursor materials. The films were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and optical absorption spectroscopy. Optical measurements revealed that pure CdS and CoS films exhibited direct band gaps of 2.4 eV and 1.6 eV, respectively, at deposition pH values of 2.5 and 6. The heterostructure films showed dual band gaps of 2.4 eV (CdS) and 1.65 eV (CoS) for CdS/CoS, and 1.45 eV (CoS) and 2.5 eV (CdS) for CoS/CdS. SEM analyses indicated that CoS films were compact with uniformly distributed grains, while CdS films displayed smooth, spherical grains free of pinholes. The CdS/CoS layers appeared denser with occasional surface defects. XRD analysis confirmed that CdS and CoS/CdS films crystallized in a cubic structure with a preferred (111) orientation, CoS exhibited a hexagonal phase, and CdS/CoS composites displayed a mixed cubic–hexagonal structure. EDX results showed a near-stoichiometric Cd/S ratio (48:52) in CdS and validated the presence of Cd, Co, and S in all prepared samples.
Abstract: In this study, cadmium Sulphide (CdS), a group II–VI semiconductor known for its wide applications in optoelectronics, piezoelectric devices, and other semiconductor technologies, and cobalt Sulphide (CoS), notable for its roles in solar-selective coatings, infrared sensing, and photo electrochemical energy storage, were investigated. Thin films of...
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