Synthesis and Properties of 2,6-Bis(1-Azaazulen-2-yl)-Pyridine
Mitsunori Oda,
Yuko Yamaga,
Yoshimitsu Kumai,
Akira Ohta,
Ryuta Miyatake
Issue:
Volume 3, Issue 2, April 2015
Pages:
14-17
Received:
25 February 2015
Accepted:
9 March 2015
Published:
15 March 2015
Abstract: The title compound, 2,6-bis(1-azaazulen-2-yl)pyridine (5), was synthesized by condensation between tropone (6) and 2,6-bis(pyridinioacetyl)pyridinium salt (7) in the presence of ammonium acetate. By slow addition of an acetic acid solution of the pyridinium salt 7 to a mixture of 6 and ammonium acetate the yield of 5 was improved. Physical properties of 5 were investigated. It is worthy to note that upon irradiation 5 shows strong emission in acidic media in contrast to very weak emission in neutral media.
Abstract: The title compound, 2,6-bis(1-azaazulen-2-yl)pyridine (5), was synthesized by condensation between tropone (6) and 2,6-bis(pyridinioacetyl)pyridinium salt (7) in the presence of ammonium acetate. By slow addition of an acetic acid solution of the pyridinium salt 7 to a mixture of 6 and ammonium acetate the yield of 5 was improved. Physical properti...
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Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex
Tarek M. Ismail,
Mosad A. EL Ghamry,
Samy M. Abu-El-Wafa,
Doaa F. Sallam
Issue:
Volume 3, Issue 2, April 2015
Pages:
18-30
Received:
1 April 2015
Accepted:
7 April 2015
Published:
27 April 2015
Abstract: Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.
Abstract: Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroli...
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