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Epidemiology of Acute Polyradiculoneuritis at Fann Department of Neurology Dakar, Senegal
Anna Modji Basse,
Soumaila Boubacar,
Adjaratou Dieynabou Sow,
Ngor Side Diagne,
Marième Soda Diop,
Ndiaga Matar Gaye,
Maouly Fall,
Ibrahima Mariam Diallo,
Ousmane Cisse,
Alassane Mamadou Diop,
Lala Bouna Seck,
Kamadore Touré,
Moustapha Ndiaye,
Amadou Gallo Diop,
Mouhamadou Mansour Ndiaye
Issue:
Volume 1, Issue 4, November 2017
Pages:
76-79
Received:
15 March 2017
Accepted:
21 April 2017
Published:
28 June 2017
DOI:
10.11648/j.cnn.20170104.11
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Abstract: The acute polyradiculoneuritis (APRN) Guillain Barre Syndrome (GBS) is the most typical case and best documented. In sub Saharan Africa, very few studies are conducted are peripheral neuropathies in general and the APR in particular. The goal of our was to determine the epidemiological profile of the patients hospitalized in our service and in the diagnosis of APRN was held. We had a retrospective study of descriptive type in Neurology department at the Fann National Teaching hospital in Dakar (Senegal). The software Epi Info6 has been used for the analysis and interpretation of data. A total 2694 patients hospitalized during the period of investigation, 39 patients (27 women and 12 men) were admitted for a GBS and which the diagnosis was retained as such depending on our criteria for inclusion. Thus, the hospital prevalence was 1.44%. The average age was 33.9 years with extremes of 11 and 74. The risk factors were dominated by the context of post-partum (63.6%) and type gastroenteritis infections (29.41%) and flu syndrome (23.5%). Albumino-cytological dissociation in the Cerebrospinal liquid (CSL) was objectified in 10 patients (45.4%) and the electroneuromyogram concluded in a demyelinating form in 48.4%, axonal form for 24% and a mixed form (27.7%). A corticosteroid therapy was administered at 53.4% of the patients. All patients had received a symptomatic and functional rehabilitation. Evolution in two months was marked by motor sequelae at 79.9%. Furthermore, 8 patients (20.5%) were transferred to unit and intensive care including mortality of (10.2%) had been recorded. Acute polyradiculoneuritis or Guillain Barre Syndrome have a professional impact. Primary prevention for reduction of morbidity and mortality attributable to this pathology.
Abstract: The acute polyradiculoneuritis (APRN) Guillain Barre Syndrome (GBS) is the most typical case and best documented. In sub Saharan Africa, very few studies are conducted are peripheral neuropathies in general and the APR in particular. The goal of our was to determine the epidemiological profile of the patients hospitalized in our service and in the ...
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Demyelinating Polyneuropathy Complicating Systemic Lupus Erythematosus: A Case Report
Patrice Ntenga,
K. Kabulo,
Bugeme M.,
Mourabit S.,
S. Boubacar,
A. Nahantchi,
Mansare L. M.,
Cisse O.,
Bakhroum M.,
Touré K.,
M. Ndiaye,
M. M. Ndiaye
Issue:
Volume 1, Issue 4, November 2017
Pages:
80-83
Received:
11 March 2017
Accepted:
1 June 2017
Published:
7 August 2017
DOI:
10.11648/j.cnn.20170104.12
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Abstract: Systemic lupus erythematosus (SLE) is an inflammatory disease of unknown cause, characterized biologically by producing multiple autoantibodies, the most characteristics are directed against some kernel components such as deoxyribonucleic acid and native nucleosomes. Neurological manifestations are frequent and polymorphous. They are dominated by central attacks, while peripheral attacks are rarer. We report the case of LS, 34 years old, female, Senegalese, divorced, and followed for years for a SLE, living in Dakar, hospitalized in October 2016 at the Neurological Clinic of FANN National Teaching Hospital, Dakar-Senegal for a demyelinating polyneuropathy complicating Systemic lupus erythematosus (SLE). An electro neuro myogram showed elongation of distal latencies in the lower limbs, lengthening of F waves in the lower limbs, and decreased conduction velocity in the lower limbs. The search for native anti-DNA antibodies was positive. The outcome was fatal with one death on day 41 of his hospitalization.
Abstract: Systemic lupus erythematosus (SLE) is an inflammatory disease of unknown cause, characterized biologically by producing multiple autoantibodies, the most characteristics are directed against some kernel components such as deoxyribonucleic acid and native nucleosomes. Neurological manifestations are frequent and polymorphous. They are dominated by c...
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Promise of Autologous Bone Marrow Stem Cell Transplantation to Patients with Spinal Cord Injury-Current Status
Mahaboob Vali Shaik,
Subrahmanyam Gangapatnam
Issue:
Volume 1, Issue 4, November 2017
Pages:
84-95
Received:
1 April 2017
Accepted:
12 May 2017
Published:
30 August 2017
DOI:
10.11648/j.cnn.20170104.13
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Abstract: Due to rapid industrialization, population raise and development of real estate business results to build of enormous constructions, which leads to the injuries of spinal cord. The burden of spinal cord injury induced limb paralysis increasing every year in India. Increasing vehicular traffic has caused numerous road traffic accidents. Spinal cord injury (SCI) affects all aspects of a patient’s life, including the physical, behavioral, psychological and social functioning. [1] Spinal cord injuries could not be treated effectively with the existing treatment modalities. In view of the above, there is definitely an urgent need for finding different methods of treatment for these patients who cannot undergo established modalities of treatment or these have been tried unsuccessfully. Since a large number of these patients will loose their productive life and at the prime of their lives one such alternate therapy, which seems to offer some promise, is “stem cell” therapy, which has been well studied and published in prestigious journals. Current review discuss the safety and therapeutic efficacy of autologous human bone marrow cell (BMC) transplantation and the administration of granulocyte macrophage-colony stimulating factor (GM-CSF).
Abstract: Due to rapid industrialization, population raise and development of real estate business results to build of enormous constructions, which leads to the injuries of spinal cord. The burden of spinal cord injury induced limb paralysis increasing every year in India. Increasing vehicular traffic has caused numerous road traffic accidents. Spinal cord ...
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Role of Propranolol and Clonidine in Sympathetic Hyperactivity After Severe Traumatic Brain Injury
Mohamed Mostafa Megahed,
Tamer Nabil Habib,
Zeyad Moqbel,
Riyad Abdullah Almogahed,
Islam El Sayed Mohamed Ahmed
Issue:
Volume 1, Issue 4, November 2017
Pages:
96-103
Received:
5 June 2017
Accepted:
22 June 2017
Published:
24 October 2017
DOI:
10.11648/j.cnn.20170104.14
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Abstract: Sympathetic hyperactivity following severe traumatic brain injury (TBI) has compounding negative consequences on many body organs. Adrenergic blockade using beta blockers and alpha 2 agonists demonstrated positive effects in decreasing sympathetic hyperactivity and increasing survival. This study was conducted on 50 adult patients with severe TBI randomly assigned into two groups. Intervention group received propranolol 40 mg BID and clonidine 150 µg BID for 7 days. Control group didn’t receive any beta blockers or alpha 2 agonists. The primary outcome was plasma norepinephrine level on day 8. Intervention group showed 20% reduction in plasma norepinephrine, while control group showed 10% reduction only. Glasgow coma score (GCS) and full outline of unresponsiveness (FOUR) score didn’t show any significant differences (p = 0.554). Heart rate was significantly decreased in intervention group (p = 0.002), mean arterial pressure also decreased (p = 0.007), as well as respiratory rate (p = 0.001). Ventilator free days, coma free days, ICU length of stay, and mortality didn’t differ significantly between the two groups. Propranolol and clonidine at the specified doses may decrease the sympathetic hyperactivity in patients suffering from severe traumatic brain injury.
Abstract: Sympathetic hyperactivity following severe traumatic brain injury (TBI) has compounding negative consequences on many body organs. Adrenergic blockade using beta blockers and alpha 2 agonists demonstrated positive effects in decreasing sympathetic hyperactivity and increasing survival. This study was conducted on 50 adult patients with severe TBI r...
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Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation
Marcellin Bugeme,
Kegnide Cadnelle Christelle Affognon,
Kouda Daniel Asta,
Salahedine Mourabit,
Olivier Mukuku
Issue:
Volume 1, Issue 4, November 2017
Pages:
104-106
Received:
22 October 2017
Accepted:
6 November 2017
Published:
11 December 2017
DOI:
10.11648/j.cnn.20170104.15
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Abstract: Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the case of a 34-year-old woman admitted to the Department of Neurology at the Fann University Hospital in Dakar for visual impairment and motor deficiency in the lower limbs of rapidly progressive onset in which clinical examination has revealed right monocular blindness and transverse myelitis. Medullary MRI and VEP enabled us to make the definitive diagnosis of optic neuromyelitis despite the negativity of AQP4 antibodies.
Abstract: Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the cas...
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