Sympathetic hyperactivity following severe traumatic brain injury (TBI) has compounding negative consequences on many body organs. Adrenergic blockade using beta blockers and alpha 2 agonists demonstrated positive effects in decreasing sympathetic hyperactivity and increasing survival. This study was conducted on 50 adult patients with severe TBI randomly assigned into two groups. Intervention group received propranolol 40 mg BID and clonidine 150 µg BID for 7 days. Control group didn’t receive any beta blockers or alpha 2 agonists. The primary outcome was plasma norepinephrine level on day 8. Intervention group showed 20% reduction in plasma norepinephrine, while control group showed 10% reduction only. Glasgow coma score (GCS) and full outline of unresponsiveness (FOUR) score didn’t show any significant differences (p = 0.554). Heart rate was significantly decreased in intervention group (p = 0.002), mean arterial pressure also decreased (p = 0.007), as well as respiratory rate (p = 0.001). Ventilator free days, coma free days, ICU length of stay, and mortality didn’t differ significantly between the two groups. Propranolol and clonidine at the specified doses may decrease the sympathetic hyperactivity in patients suffering from severe traumatic brain injury.
| Published in | Clinical Neurology and Neuroscience (Volume 1, Issue 4) |
| DOI | 10.11648/j.cnn.20170104.14 |
| Page(s) | 96-103 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Critical, Neurology, Trauma, β-Blocker, α-Agonist
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APA Style
Mohamed Mostafa Megahed, Tamer Nabil Habib, Zeyad Moqbel, Riyad Abdullah Almogahed, Islam El Sayed Mohamed Ahmed. (2017). Role of Propranolol and Clonidine in Sympathetic Hyperactivity After Severe Traumatic Brain Injury. Clinical Neurology and Neuroscience, 1(4), 96-103. https://doi.org/10.11648/j.cnn.20170104.14
ACS Style
Mohamed Mostafa Megahed; Tamer Nabil Habib; Zeyad Moqbel; Riyad Abdullah Almogahed; Islam El Sayed Mohamed Ahmed. Role of Propranolol and Clonidine in Sympathetic Hyperactivity After Severe Traumatic Brain Injury. Clin. Neurol. Neurosci. 2017, 1(4), 96-103. doi: 10.11648/j.cnn.20170104.14
AMA Style
Mohamed Mostafa Megahed, Tamer Nabil Habib, Zeyad Moqbel, Riyad Abdullah Almogahed, Islam El Sayed Mohamed Ahmed. Role of Propranolol and Clonidine in Sympathetic Hyperactivity After Severe Traumatic Brain Injury. Clin Neurol Neurosci. 2017;1(4):96-103. doi: 10.11648/j.cnn.20170104.14
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Download@article{10.11648/j.cnn.20170104.14,
author = {Mohamed Mostafa Megahed and Tamer Nabil Habib and Zeyad Moqbel and Riyad Abdullah Almogahed and Islam El Sayed Mohamed Ahmed},
title = {Role of Propranolol and Clonidine in Sympathetic Hyperactivity After Severe Traumatic Brain Injury},
journal = {Clinical Neurology and Neuroscience},
volume = {1},
number = {4},
pages = {96-103},
doi = {10.11648/j.cnn.20170104.14},
url = {https://doi.org/10.11648/j.cnn.20170104.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20170104.14},
abstract = {Sympathetic hyperactivity following severe traumatic brain injury (TBI) has compounding negative consequences on many body organs. Adrenergic blockade using beta blockers and alpha 2 agonists demonstrated positive effects in decreasing sympathetic hyperactivity and increasing survival. This study was conducted on 50 adult patients with severe TBI randomly assigned into two groups. Intervention group received propranolol 40 mg BID and clonidine 150 µg BID for 7 days. Control group didn’t receive any beta blockers or alpha 2 agonists. The primary outcome was plasma norepinephrine level on day 8. Intervention group showed 20% reduction in plasma norepinephrine, while control group showed 10% reduction only. Glasgow coma score (GCS) and full outline of unresponsiveness (FOUR) score didn’t show any significant differences (p = 0.554). Heart rate was significantly decreased in intervention group (p = 0.002), mean arterial pressure also decreased (p = 0.007), as well as respiratory rate (p = 0.001). Ventilator free days, coma free days, ICU length of stay, and mortality didn’t differ significantly between the two groups. Propranolol and clonidine at the specified doses may decrease the sympathetic hyperactivity in patients suffering from severe traumatic brain injury.},
year = {2017}
}
TY - JOUR T1 - Role of Propranolol and Clonidine in Sympathetic Hyperactivity After Severe Traumatic Brain Injury AU - Mohamed Mostafa Megahed AU - Tamer Nabil Habib AU - Zeyad Moqbel AU - Riyad Abdullah Almogahed AU - Islam El Sayed Mohamed Ahmed Y1 - 2017/10/24 PY - 2017 N1 - https://doi.org/10.11648/j.cnn.20170104.14 DO - 10.11648/j.cnn.20170104.14 T2 - Clinical Neurology and Neuroscience JF - Clinical Neurology and Neuroscience JO - Clinical Neurology and Neuroscience SP - 96 EP - 103 PB - Science Publishing Group SN - 2578-8930 UR - https://doi.org/10.11648/j.cnn.20170104.14 AB - Sympathetic hyperactivity following severe traumatic brain injury (TBI) has compounding negative consequences on many body organs. Adrenergic blockade using beta blockers and alpha 2 agonists demonstrated positive effects in decreasing sympathetic hyperactivity and increasing survival. This study was conducted on 50 adult patients with severe TBI randomly assigned into two groups. Intervention group received propranolol 40 mg BID and clonidine 150 µg BID for 7 days. Control group didn’t receive any beta blockers or alpha 2 agonists. The primary outcome was plasma norepinephrine level on day 8. Intervention group showed 20% reduction in plasma norepinephrine, while control group showed 10% reduction only. Glasgow coma score (GCS) and full outline of unresponsiveness (FOUR) score didn’t show any significant differences (p = 0.554). Heart rate was significantly decreased in intervention group (p = 0.002), mean arterial pressure also decreased (p = 0.007), as well as respiratory rate (p = 0.001). Ventilator free days, coma free days, ICU length of stay, and mortality didn’t differ significantly between the two groups. Propranolol and clonidine at the specified doses may decrease the sympathetic hyperactivity in patients suffering from severe traumatic brain injury. VL - 1 IS - 4 ER -
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