-
Dopa-Responsive Dystonia with Diurnal Fluctuation: A Case Report of an 18 Year Old Nigerian
Olusegun Adesola Busari,
Paul Olowoyo,
Segun Oladele Adeniyi,
Bidemi Olayemi Onipede,
Olisa Joseph,
Solomon Ogunniran
Issue:
Volume 2, Issue 2, June 2018
Pages:
23-26
Received:
25 October 2017
Accepted:
3 February 2018
Published:
4 July 2018
Abstract: Dopa-responsive dystonia, also known as hereditary progressive dystonia with diurnal variation, is a genetic disease characterized by childhood or adolescent onset of dystonia and sometimes associated with parkinsonian features. This is a case report of an 18 year old Nigerian University undergraduate with features of difficulty in speaking, stiffness of the body, gait difficulties, coarse tremors and toe-walking. There was a very marked improvement of symptoms and signs within 24-48 hours of the commencement of SinemetTM (levodopa/ carbidopa) 125mg/12.5mg daily. The patient was discharged after 5 days with normal gait.
Abstract: Dopa-responsive dystonia, also known as hereditary progressive dystonia with diurnal variation, is a genetic disease characterized by childhood or adolescent onset of dystonia and sometimes associated with parkinsonian features. This is a case report of an 18 year old Nigerian University undergraduate with features of difficulty in speaking, stiffn...
Show More
-
Clinical Implications Related to the Use of Drugs Illicit and Licit During the Pregnancy
Jair Alves Maia,
Alesandro Lima Rodrigues,
Denisa Rosa de Souza,
Mediã Barbosa Figueiredo
Issue:
Volume 2, Issue 2, June 2018
Pages:
27-32
Received:
15 June 2018
Accepted:
27 June 2018
Published:
24 July 2018
Abstract: Introduction: the use of drugs has been growing quickly and continuously in the general population, where teenagers, young, old and even children are entering this world intense and devastating. Already in women users this picture is even more worrying when it comes to consumption during pregnancy. Objective: to identify the most commonly used drugs for pregnant women who performed prenatal care in a primary care Reference Unit of Rio Branco, Acre, in the period from 28 August to 28 September 2017. Methodology: this is a cross-sectional field study of observational, descriptive, exploratory character, basic quantitative approach on drug use by women during the gestational period. Results: the analysis of the data collected has identified that during the period were pregnant gestational use of substances: 18 (60%) used alcohol, 9 (30%) smoked cigarettes, 2 (6.7%) was associated with use of alcohol and cigarettes and 1 (3.3%) reported use of alcohol, cigarette, marijuana, cocaine and crack, concurrently. Conclusion: the use of drugs during the gestational period brings multiple consequences to the body of the mother and the fetus, of which are intrauterine growth restricted, congenital malformations, miscarriage, premature labour, premature separation of placenta, placenta previa and death Fetal. And it is important to note that the professionals working on prenatal consultation strategies should be used to prevent and relieve the drug use in gestational period.
Abstract: Introduction: the use of drugs has been growing quickly and continuously in the general population, where teenagers, young, old and even children are entering this world intense and devastating. Already in women users this picture is even more worrying when it comes to consumption during pregnancy. Objective: to identify the most commonly used drug...
Show More
-
Primary Leptomeningeal Lymphoma Presenting as Low Back Pain and Dementia: A Case Report
Vida Margarette de Vera Andal,
Julette Marie Feliciano Batara,
Joven Racpan Cuanang
Issue:
Volume 2, Issue 2, June 2018
Pages:
33-40
Received:
31 May 2018
Accepted:
4 July 2018
Published:
30 July 2018
Abstract: Primary leptomeningeal lymphoma (PLL) is an extremely rare condition, with only a handful of cases reported in literature. Most often, these are misdiagnosed as other disease entities that are more commonly observed in practice. Currently, there are no clinical algorithms that may guide clinicians to clinching a diagnosis of PLL. This paper discusses a remarkable case of PLL presenting with atypical symptoms namely dementia and low back pain. This is a case of an apparently well adult male who initially presented with low back pain that was treated for two years as a case of lumbar disc herniation. This developed into lower extremity weakness and was subsequently followed by dementia and seizures. The patient was initially treated for tuberculous meningitis after CSF findings showed lymphocytic predominance. However, lack of clinical improvement prompted further work up revealing a malignant process in the lumbosacral meninges. Dural biopsy showed atypical mononuclear infiltrates consistent with a B-cell non-Hodgkin lymphoma with immunohistochemistry showing CD20 positive, CD79a positive, CD3 negative. Being MUM1 positive and BCL2 positive suggests it being a diffuse large B cell lymphoma. A primary malignancy of the leptomeninges was ruled in after PET CT showed no other sites of high metabolic activity. The patient was able to complete 6 cycles of high dose Methotrexate and three Rituximab doses. Remarkably, after more than two years after his initial presentation, he still has mild signs of dementia but is able to carry out most activities of daily living with minimal assistance. The patient has survived beyond the expected life expectancy for PLL.
Abstract: Primary leptomeningeal lymphoma (PLL) is an extremely rare condition, with only a handful of cases reported in literature. Most often, these are misdiagnosed as other disease entities that are more commonly observed in practice. Currently, there are no clinical algorithms that may guide clinicians to clinching a diagnosis of PLL. This paper discuss...
Show More
-
Cerebral Hydatitosis: About 12 Observations at the University Hospital Center of Conakry
Fodé Abass Cisse,
Foksouna Sakadi,
Amina Sakho,
Naby Camara,
Barry Souleymane Djigué,
Arcel Steven Nitcheu Woga,
Nana Rahamatou Aminou Tassiou,
Baldé Amadou Talib,
Bi Krah Jean Bedel Ballo,
Mohamed Lamine Touré,
Ibrahima Sory Souaré,
Amara Cisse
Issue:
Volume 2, Issue 2, June 2018
Pages:
41-45
Received:
28 May 2018
Accepted:
3 July 2018
Published:
1 August 2018
Abstract: Cosmopolitan disease, hydatidosis is caused by the hydatid larvae of a tapeworm of Echinococcus granulosus canes developing in the liver, lungs, heart and central nervous system. The biological certainty of brain damage in West Africa is difficult to confirm because of the supposed rarity of this affection and the difficulties of accessibility to MRI and CT radiological data suggestive of the disease. We retrospectively analyzed the file of 268 patients hospitalized in the Neurology Department between 2010 and 2016 for the management of encephalic syndrome with cystic neuroradiological cerebral lesions. Biological and neuroradiological evidence of hydatidosis was reported in 12 patients (4, 47%). An encephalic and infectious syndrome: headache, nausea and vomiting, fever, disorders of consciousness, sensitivo-motor deficit with hemiparesis type, cerebellar syndrome and sometimes visual disorders, expression of intracranial hypertension was found in patients. These elements of intracranial hypertension objectified in most patients, were associated in 3 cases with liver disorders. The biological data haemagglutination, Eliza, moderate eosinophilia, radiological CT / MRI and the demonstration of scolex during percutaneous aspirations (2 cases) and on operative specimens were the diagnostic confirmation beam.
Abstract: Cosmopolitan disease, hydatidosis is caused by the hydatid larvae of a tapeworm of Echinococcus granulosus canes developing in the liver, lungs, heart and central nervous system. The biological certainty of brain damage in West Africa is difficult to confirm because of the supposed rarity of this affection and the difficulties of accessibility to M...
Show More
