Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation

Marcellin Bugeme; Kegnide Cadnelle Christelle Affognon; Kouda Daniel Asta; Salahedine Mourabit; Olivier Mukuku

doi:doi:10.11648/j.cnn.20170104.15

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Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation

Marcellin Bugeme, Kegnide Cadnelle Christelle Affognon, Kouda Daniel Asta, Salahedine Mourabit, Olivier Mukuku

Published in Clinical Neurology and Neuroscience (Volume 1, Issue 4)

Received: 22 October 2017 Accepted: 6 November 2017 Published: 11 December 2017

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Abstract

Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the case of a 34-year-old woman admitted to the Department of Neurology at the Fann University Hospital in Dakar for visual impairment and motor deficiency in the lower limbs of rapidly progressive onset in which clinical examination has revealed right monocular blindness and transverse myelitis. Medullary MRI and VEP enabled us to make the definitive diagnosis of optic neuromyelitis despite the negativity of AQP4 antibodies.

Published in	Clinical Neurology and Neuroscience (Volume 1, Issue 4)
DOI	10.11648/j.cnn.20170104.15
Page(s)	104-106
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Neuromyelitis Optica, Anti-AQP4, Antibodies

References

[1]	Daouda MT, Obenda NS, Assadeck H, Camara D, Djibo FH. Traitement de la neuromyélite optique de Devic durant de la grossesse. The Pan African Medical Journal 2016; 24.
[2]	Boulefkhad A, Taghane N, Hamri M. Neuromyélite optique de Devic (NMO): analyse clinique, radiologique et profil évolutif. Revue Neurologique 2013; 169: A153.
[3]	Marignier R, Bernard-Valnet R, Giraudon P, Collongues N, Papeix C, Zéphir H, et al. Aquaporin-4 antibody–negative neuromyelitis optica Distinct assay sensitivity–dependent entity. Neurology 2013; 80 (24): 2194-2200.
[4]	Barateau L, Papillon G, Olivier N, Cisse B, Fadat B, Gaillard N, Mas J. Neuromyélite optique à AC AQP4/NMO-IGG négatif: à propos de 3 observations. Revue Neurologique 2012; 168, A135.
[5]	Weinshenker BG. Neuromyelitis optica: what it is and what it might be. Lancet. 2003; 361 (9361): 889–90.
[6]	Papeix C. La maladie de Devic en quelques points. La Lettre du neurologue 2007; 11 (2): 50-52.
[7]	Bourmatte S, Boulefkhad A, Sifi Y, Taghane N, Hamri A. Neuromyélite optique de Devic: à propos de 15 cas. Revue Neurologique 2016; 172: A32.
[8]	Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015; 85 (2): 177-189.
[9]	Cabre P, Gonzalez-Quevedo A, Lannuzel A, Bonnan M, Merle H, Olindo S, et al. Épidemiologie descriptive de la neuromyélite optique dans le bassin caraibéen. Revue neurologique 2009; 165 (8): 676-683.
[10]	Papeix C. Maladie de Devic. Presse Méd. 2006; 35: 1703-6.
[11]	Bouzidi N, Turki E, Dammak M, Mhiri C. Formes atypiques de neuro-myélite optique. Feuillets de Radiologie 2015; 55 (4): 231-235.
[12]	Bencherif MZ, Karib H, Tachfouti S, Guedira K, Mohcine Z. Neuromyélite optique de Devic chez l'enfant. Journal Français d'Ophtalmologie 2000; 23 (5): 488.
[13]	Déral-Stéphant V, Roux-Lelièvre C, Vignal R, Stéphant E, Faivre A, Alla P. Neuromyélite optique de Devic: discussion diagnostique après dix ans d’évolution d’une neuropathie optique bilatérale sévère. Journal Francais d'Ophtalmologie 2008; 31 (7): 705-709.
[14]	Bonnan M, Brasme H, Diaby MM, Vlaicu M, Le Guern V, Zuber M. Poussées sévères de neuromyélite optique: efficacité spectaculaire des échanges plasmatiques. Revue Neurologique 2009; 165 (5): 479-481.
[15]	Mandler RN. Neuromyelitis optica—Devic's syndrome, update. Autoimmunity reviews 2006; 5 (8): 537-543.

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APA Style

Marcellin Bugeme, Kegnide Cadnelle Christelle Affognon, Kouda Daniel Asta, Salahedine Mourabit, Olivier Mukuku. (2017). Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation. Clinical Neurology and Neuroscience, 1(4), 104-106. https://doi.org/10.11648/j.cnn.20170104.15

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ACS Style

Marcellin Bugeme; Kegnide Cadnelle Christelle Affognon; Kouda Daniel Asta; Salahedine Mourabit; Olivier Mukuku. Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation. Clin. Neurol. Neurosci. 2017, 1(4), 104-106. doi: 10.11648/j.cnn.20170104.15

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AMA Style

Marcellin Bugeme, Kegnide Cadnelle Christelle Affognon, Kouda Daniel Asta, Salahedine Mourabit, Olivier Mukuku. Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation. Clin Neurol Neurosci. 2017;1(4):104-106. doi: 10.11648/j.cnn.20170104.15

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@article{10.11648/j.cnn.20170104.15,
  author = {Marcellin Bugeme and Kegnide Cadnelle Christelle Affognon and Kouda Daniel Asta and Salahedine Mourabit and Olivier Mukuku},
  title = {Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation},
  journal = {Clinical Neurology and Neuroscience},
  volume = {1},
  number = {4},
  pages = {104-106},
  doi = {10.11648/j.cnn.20170104.15},
  url = {https://doi.org/10.11648/j.cnn.20170104.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20170104.15},
  abstract = {Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the case of a 34-year-old woman admitted to the Department of Neurology at the Fann University Hospital in Dakar for visual impairment and motor deficiency in the lower limbs of rapidly progressive onset in which clinical examination has revealed right monocular blindness and transverse myelitis. Medullary MRI and VEP enabled us to make the definitive diagnosis of optic neuromyelitis despite the negativity of AQP4 antibodies.},
 year = {2017}
}

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TY  - JOUR
T1  - Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation
AU  - Marcellin Bugeme
AU  - Kegnide Cadnelle Christelle Affognon
AU  - Kouda Daniel Asta
AU  - Salahedine Mourabit
AU  - Olivier Mukuku
Y1  - 2017/12/11
PY  - 2017
N1  - https://doi.org/10.11648/j.cnn.20170104.15
DO  - 10.11648/j.cnn.20170104.15
T2  - Clinical Neurology and Neuroscience
JF  - Clinical Neurology and Neuroscience
JO  - Clinical Neurology and Neuroscience
SP  - 104
EP  - 106
PB  - Science Publishing Group
SN  - 2578-8930
UR  - https://doi.org/10.11648/j.cnn.20170104.15
AB  - Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the case of a 34-year-old woman admitted to the Department of Neurology at the Fann University Hospital in Dakar for visual impairment and motor deficiency in the lower limbs of rapidly progressive onset in which clinical examination has revealed right monocular blindness and transverse myelitis. Medullary MRI and VEP enabled us to make the definitive diagnosis of optic neuromyelitis despite the negativity of AQP4 antibodies.
VL  - 1
IS  - 4
ER  -

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Author Information

Marcellin Bugeme

Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Kegnide Cadnelle Christelle Affognon

Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Kouda Daniel Asta

Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Salahedine Mourabit

Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Olivier Mukuku

Department de Recherche, Institut Supérieur des Techniques Médicales de Lubumbaashi, Lubumbashi, Democratic Republic of Congo

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APA Style

Marcellin Bugeme, Kegnide Cadnelle Christelle Affognon, Kouda Daniel Asta, Salahedine Mourabit, Olivier Mukuku. (2017). Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation. Clinical Neurology and Neuroscience, 1(4), 104-106. https://doi.org/10.11648/j.cnn.20170104.15

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ACS Style

Marcellin Bugeme; Kegnide Cadnelle Christelle Affognon; Kouda Daniel Asta; Salahedine Mourabit; Olivier Mukuku. Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation. Clin. Neurol. Neurosci. 2017, 1(4), 104-106. doi: 10.11648/j.cnn.20170104.15

Copy | Download

AMA Style

Marcellin Bugeme, Kegnide Cadnelle Christelle Affognon, Kouda Daniel Asta, Salahedine Mourabit, Olivier Mukuku. Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation. Clin Neurol Neurosci. 2017;1(4):104-106. doi: 10.11648/j.cnn.20170104.15

Copy | Download

@article{10.11648/j.cnn.20170104.15,
  author = {Marcellin Bugeme and Kegnide Cadnelle Christelle Affognon and Kouda Daniel Asta and Salahedine Mourabit and Olivier Mukuku},
  title = {Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation},
  journal = {Clinical Neurology and Neuroscience},
  volume = {1},
  number = {4},
  pages = {104-106},
  doi = {10.11648/j.cnn.20170104.15},
  url = {https://doi.org/10.11648/j.cnn.20170104.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20170104.15},
  abstract = {Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the case of a 34-year-old woman admitted to the Department of Neurology at the Fann University Hospital in Dakar for visual impairment and motor deficiency in the lower limbs of rapidly progressive onset in which clinical examination has revealed right monocular blindness and transverse myelitis. Medullary MRI and VEP enabled us to make the definitive diagnosis of optic neuromyelitis despite the negativity of AQP4 antibodies.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation
AU  - Marcellin Bugeme
AU  - Kegnide Cadnelle Christelle Affognon
AU  - Kouda Daniel Asta
AU  - Salahedine Mourabit
AU  - Olivier Mukuku
Y1  - 2017/12/11
PY  - 2017
N1  - https://doi.org/10.11648/j.cnn.20170104.15
DO  - 10.11648/j.cnn.20170104.15
T2  - Clinical Neurology and Neuroscience
JF  - Clinical Neurology and Neuroscience
JO  - Clinical Neurology and Neuroscience
SP  - 104
EP  - 106
PB  - Science Publishing Group
SN  - 2578-8930
UR  - https://doi.org/10.11648/j.cnn.20170104.15
AB  - Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the case of a 34-year-old woman admitted to the Department of Neurology at the Fann University Hospital in Dakar for visual impairment and motor deficiency in the lower limbs of rapidly progressive onset in which clinical examination has revealed right monocular blindness and transverse myelitis. Medullary MRI and VEP enabled us to make the definitive diagnosis of optic neuromyelitis despite the negativity of AQP4 antibodies.
VL  - 1
IS  - 4
ER  -

Copy | Download