Abstract: Objective: The aim of the present study was to assess the status of renal function in rheumatoid arthritis patients. Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. According to selection criteria one hundred subjects were selected with the age ranging from 20-60 years and equally divided into two groups. Group-A fifty diagnosed case of rheumatoid arthritis patients attending in the OPD of Arthritis Care and Research Centre and SLE Clinic, Department of Medicine, Dhaka Medical College Hospital and Group-B fifty apparently healthy individuals. The study parameters were serum creatinine, eGFR, serum urea, BMI, RA factor and anti-citrullinated protein antibody (ACPA). The results were compared statistically between two groups. Results: Serum creatinine (mg/dl) (mean ± SD) level was significantly higher (p <0.032) in RA (0.85± 0.17) than normal individuals (0.78± 0.15). Level of eGFR (ml/min/1.73m2) (mean ± SD) level was significantly lower (p <0.042) in RA (84.5 ± 20.3) than normal individuals (92.7± 19.5). Serum urea (mg/dl) (mean ± SD) level was significantly higher (p <0.011) in RA (33.12 ± 9.46) than normal individuals (28.51± 8.28). RA factor (IU/ml) and anti-citrullinated protein antibody (ACPA, U/ml) (mean ± SD) level was significantly higher (p <0.001) in RA (37.4± 13.6 and 23.5± 8.3 respectively) than normal individual (11.7± 3.25 and 7.3± 1.65 respectively). The BMI (kg/m²) (mean ± SD) was significantly higher (p <0.0001) in RA (28.5 ± 4.8) than normal individuals (21.1± 3.7). Conclusion: Serum creatinine is positively correlated to RA factor and ACPA in both groups and eGFR is negatively correlated to RA factor and ACPA in both groups. Routine screening of renal function may be beneficial for rheumatoid arthritis patients to prevent renal complications.Abstract: Objective: The aim of the present study was to assess the status of renal function in rheumatoid arthritis patients. Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. According to selection criteria one hundred subjects were selected with the age ranging from ...Show More
Abstract: Acquired platelet dysfunction with eosinophilia (APDE) first reported in 1975 is an acquired, transient bleeding disorder of unknown etiology characterized by spontaneous ecchymosis, eosinophilia and platelet dysfunction. This bleeding disorder, otherwise known as “non-thrombocytopenic purpura with eosinophilia”, occurs commonly in indigenous Southeast Asian children. Cases of APDE occur rarely outside this endemic area. This syndrome runs a benign course and patients can recuperate spontaneously from the bleeding episodes within 6 months to a year. The aim of our case report is to highlight the importance of recognizing this little known bleeding disorder in our daily clinical practice. We reported the first documented case of a 7 year old girl managed in our hospital “Omer Nishani”, with clinical features characteristic of APDE. The patient was in good health, presented with spontaneous bruising on the extremities with no organomegaly. Marked eosinophilia and prolonged bleeding time with normal platelet count were noted on laboratory work-up. The patient was started on antiparasitic therapy despite negative stool results, and subsequent follow-up after 3 weeks showed resolution of ecchymosis and eosinophilia. Awareness of this benign bleeding disorder, which clinically mimics Idiopathic Thrombocytopenic Purpura (ITP) would help to diagnose and treat early, and lessen parental anxiety.Abstract: Acquired platelet dysfunction with eosinophilia (APDE) first reported in 1975 is an acquired, transient bleeding disorder of unknown etiology characterized by spontaneous ecchymosis, eosinophilia and platelet dysfunction. This bleeding disorder, otherwise known as “non-thrombocytopenic purpura with eosinophilia”, occurs commonly in indigenous South...Show More
