Abstract: Kaposi sarcoma (KS), first described in 1872 by the dermatologist Moricz Cohen Kaposi, is the most common neoplasm of people living with HIV today. Kaposi Sarcoma remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. We report the case of two patients from Niger, aged 43 and 65 years old, who consulted unit of HIV care the Niamey Regional Hospital for an exploration of skin lesions in a context of altered general condition including significant weight loss. The clinical diagnosis of Kaposi's disease on a background of HIV immunodeficiency was retained. The clinical lesions were infiltrating cuteneous bluish nodular skin lesions with macules located on the legs, forearm and abdomen. The treatment consisted in putting the patients on high antiretroviral treatment followed by courses of chemotherapy. The combination of high antiretroviral therapy was started with TDF-3TC-EFV one tablet daily at bedtime. These study show the clinical polymorphism, the diagnostic delay and the treatment including polychemotherapy and antiretroviral drugs. Early diagnosis and detection of lesions could improve management and the prognosis of this disease.
Abstract: Kaposi sarcoma (KS), first described in 1872 by the dermatologist Moricz Cohen Kaposi, is the most common neoplasm of people living with HIV today. Kaposi Sarcoma remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. We report the case of two patients from Niger, aged 43...Show More
Abstract: Pseudohypoparathyroidism is a group of rare, related and highly heterogeneous disorders characterized by target organ resistance to the action of parathyroid hormone. Pseudohypoparathyroidism and related disorders are caused by genetic and/or epigenetic changes resulting in downregulation of a cyclic adenosine mono phosphate generator primarily linked to the GNAS gene, patients who have experienced hormonal parathyroid (hypocalcemia and hyperphosphatemia resistant to parathyroid hormone with characteristic skeletal and developmental changes. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, hereditary osteodystrophy; Albright, pseudohypoparathyroidism, McCune-Albright syndrome, progressive bone heteroplasia, polyostotic fibrous dysplasia of bone, and certain pituitary tumors Here we report a series of 3 cases carrying pseudohypopathyroidism, their sociodemographic, clinical and paraclinical aspects as well as therapeutic.
Abstract: Pseudohypoparathyroidism is a group of rare, related and highly heterogeneous disorders characterized by target organ resistance to the action of parathyroid hormone. Pseudohypoparathyroidism and related disorders are caused by genetic and/or epigenetic changes resulting in downregulation of a cyclic adenosine mono phosphate generator primarily lin...Show More
