A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster

Mikel Koti; Edmond Kotoni; Anthulla Kajo; Asife Shehaj; Flasilda Brahimi

doi:doi:10.11648/j.ijmcr.20230201.12

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A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster

Mikel Koti, Edmond Kotoni, Anthulla Kajo, Asife Shehaj, Flasilda Brahimi

Published in International Journal of Medical Case Reports (Volume 2, Issue 1)

Received: 5 December 2022 Accepted: 9 January 2023 Published: 31 January 2023

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Abstract

Acquired platelet dysfunction with eosinophilia (APDE) first reported in 1975 is an acquired, transient bleeding disorder of unknown etiology characterized by spontaneous ecchymosis, eosinophilia and platelet dysfunction. This bleeding disorder, otherwise known as “non-thrombocytopenic purpura with eosinophilia”, occurs commonly in indigenous Southeast Asian children. Cases of APDE occur rarely outside this endemic area. This syndrome runs a benign course and patients can recuperate spontaneously from the bleeding episodes within 6 months to a year. The aim of our case report is to highlight the importance of recognizing this little known bleeding disorder in our daily clinical practice. We reported the first documented case of a 7 year old girl managed in our hospital “Omer Nishani”, with clinical features characteristic of APDE. The patient was in good health, presented with spontaneous bruising on the extremities with no organomegaly. Marked eosinophilia and prolonged bleeding time with normal platelet count were noted on laboratory work-up. The patient was started on antiparasitic therapy despite negative stool results, and subsequent follow-up after 3 weeks showed resolution of ecchymosis and eosinophilia. Awareness of this benign bleeding disorder, which clinically mimics Idiopathic Thrombocytopenic Purpura (ITP) would help to diagnose and treat early, and lessen parental anxiety.

Published in	International Journal of Medical Case Reports (Volume 2, Issue 1)
DOI	10.11648/j.ijmcr.20230201.12
Page(s)	5-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

APDE, Eosinophilia, Ecchymosis

References

[1]	Shih MY, Wang RC, Liang CW, Wang JD. Acquired platelet dysfunction with eosinophilia in two patients. Pediatr Neonatol 2020; 61 (3): 346-347. PMID: 32249099. https://doi.org/10.1016/j.pedneo.2020.03.004.
[2]	Lee AC-W. Unusual hematologic disease affecting Caucasian children travelling to Southeast Asia: acquired platelet dysfunction with eosinophilia. Hematol Rep. 2012; 4 (1): e5. doi: 10.4081/hr.2012.e5.
[3]	Chotsampancharoen T, Sripornsawan P, Duangchu S, McNeil E. Clinical course and outcome of childhood acquired platelet dysfunction with eosinophilia. Acta Haematol 2018; 139: 28e32.
[4]	Laosombat V, Wongchanchailert M, Sattayasevana B, Kietthubthew S, Wiriyasateinkul A. Acquired platelet dysfunction with eosinophilia in children in the south of Thailand. Platelets. 2001; 12 (1): 5–14. doi: 10.1080/09537100020031180.
[5]	Lim SH, Tan CE, Agasthian T, Chew LS. Acquired platelet dysfunction with eosinophilia: review of seven adult cases. J Clin Pathol. 1989; 42: 950–952. doi: 10.1136/jcp.42.9.950.
[6]	Suvatte V, Mahasandana C, Tanphaichitr V, Tuchinad S. Acquired platelet dysfunction in 62 cases. Southeast Asian J Trop Med Pub Hlth 1979; 10: 358-367.
[7]	Anselm Chi-wai Lee Children’s Haematology and Cancer Centre, Mount Elizabeth Hospital, Singapore Unusual hematologic disease affecting Caucasian children traveling to Southeast Asia: acquired platelet dysfunction with eosinophilia. Hematology Reports 2012; volume 4: e5.
[8]	Ramanathan M, Duraisamy G. Acquired platelet dysfunction with eosinophilia (APDE): an under recognised condition. Med J Malaysia. 1987 Mar; 42 (1): 53-55.
[9]	Lucas GN. Acquired platelet dysfunction with eosinophilia (APDE) Sri Lanka J Child Health. 2002; 31: 89–90. doi: 10.4038/sljch.v31i3.771.
[10]	Isarangkura P, Hathirat P, Bintadish P, Lolekha S, Sasanakul W. Platelet morphology and immunologic study in acquired platelet dysfunction with eosinophilia (APDE). In: 3rd Asian Congress of Pediatrics Bangkok, Thailand 1979: 83.
[11]	Mitrakul C. Transient, spontaneous bruising with long bleeding time and normal platelet count. Am J Clin Pathol 1975; 63: 81e6.
[12]	Szczeklik A, Milner PC, Birch J, Watkins J, Martin JF. Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Thromb Haemost 1986; 56: 283e7.
[13]	Parttraporn Isarangkura. Acquired Platelet Dysfunction with Eosinophilia. International Hematology Society Meeting, Bangkok 1999; 24-28: 160-161.
[14]	Chin NS, Koong PLA study of 31 patients with easy bruising from University Hospital, Kuala Lumpur. Med J Malaysia. 1990. Dec; 45 (4): 325-328.
[15]	Suvatte V, Mahasandana C, Tanphaichitr V, Tuchinda S. Acquired platelet dysfunction with eosinophilia: Study of platelet function in 62 cases. Southeast Asian J Trop Med Pub Hlth. 1979; 10: 358-367.

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APA Style

Mikel Koti, Edmond Kotoni, Anthulla Kajo, Asife Shehaj, Flasilda Brahimi. (2023). A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster. International Journal of Medical Case Reports, 2(1), 5-7. https://doi.org/10.11648/j.ijmcr.20230201.12

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ACS Style

Mikel Koti; Edmond Kotoni; Anthulla Kajo; Asife Shehaj; Flasilda Brahimi. A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster. Int. J. Med. Case Rep. 2023, 2(1), 5-7. doi: 10.11648/j.ijmcr.20230201.12

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AMA Style

Mikel Koti, Edmond Kotoni, Anthulla Kajo, Asife Shehaj, Flasilda Brahimi. A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster. Int J Med Case Rep. 2023;2(1):5-7. doi: 10.11648/j.ijmcr.20230201.12

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@article{10.11648/j.ijmcr.20230201.12,
  author = {Mikel Koti and Edmond Kotoni and Anthulla Kajo and Asife Shehaj and Flasilda Brahimi},
  title = {A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster},
  journal = {International Journal of Medical Case Reports},
  volume = {2},
  number = {1},
  pages = {5-7},
  doi = {10.11648/j.ijmcr.20230201.12},
  url = {https://doi.org/10.11648/j.ijmcr.20230201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmcr.20230201.12},
  abstract = {Acquired platelet dysfunction with eosinophilia (APDE) first reported in 1975 is an acquired, transient bleeding disorder of unknown etiology characterized by spontaneous ecchymosis, eosinophilia and platelet dysfunction. This bleeding disorder, otherwise known as “non-thrombocytopenic purpura with eosinophilia”, occurs commonly in indigenous Southeast Asian children. Cases of APDE occur rarely outside this endemic area. This syndrome runs a benign course and patients can recuperate spontaneously from the bleeding episodes within 6 months to a year. The aim of our case report is to highlight the importance of recognizing this little known bleeding disorder in our daily clinical practice. We reported the first documented case of a 7 year old girl managed in our hospital “Omer Nishani”, with clinical features characteristic of APDE. The patient was in good health, presented with spontaneous bruising on the extremities with no organomegaly. Marked eosinophilia and prolonged bleeding time with normal platelet count were noted on laboratory work-up. The patient was started on antiparasitic therapy despite negative stool results, and subsequent follow-up after 3 weeks showed resolution of ecchymosis and eosinophilia. Awareness of this benign bleeding disorder, which clinically mimics Idiopathic Thrombocytopenic Purpura (ITP) would help to diagnose and treat early, and lessen parental anxiety.},
 year = {2023}
}

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TY  - JOUR
T1  - A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster
AU  - Mikel Koti
AU  - Edmond Kotoni
AU  - Anthulla Kajo
AU  - Asife Shehaj
AU  - Flasilda Brahimi
Y1  - 2023/01/31
PY  - 2023
N1  - https://doi.org/10.11648/j.ijmcr.20230201.12
DO  - 10.11648/j.ijmcr.20230201.12
T2  - International Journal of Medical Case Reports
JF  - International Journal of Medical Case Reports
JO  - International Journal of Medical Case Reports
SP  - 5
EP  - 7
PB  - Science Publishing Group
SN  - 2994-7049
UR  - https://doi.org/10.11648/j.ijmcr.20230201.12
AB  - Acquired platelet dysfunction with eosinophilia (APDE) first reported in 1975 is an acquired, transient bleeding disorder of unknown etiology characterized by spontaneous ecchymosis, eosinophilia and platelet dysfunction. This bleeding disorder, otherwise known as “non-thrombocytopenic purpura with eosinophilia”, occurs commonly in indigenous Southeast Asian children. Cases of APDE occur rarely outside this endemic area. This syndrome runs a benign course and patients can recuperate spontaneously from the bleeding episodes within 6 months to a year. The aim of our case report is to highlight the importance of recognizing this little known bleeding disorder in our daily clinical practice. We reported the first documented case of a 7 year old girl managed in our hospital “Omer Nishani”, with clinical features characteristic of APDE. The patient was in good health, presented with spontaneous bruising on the extremities with no organomegaly. Marked eosinophilia and prolonged bleeding time with normal platelet count were noted on laboratory work-up. The patient was started on antiparasitic therapy despite negative stool results, and subsequent follow-up after 3 weeks showed resolution of ecchymosis and eosinophilia. Awareness of this benign bleeding disorder, which clinically mimics Idiopathic Thrombocytopenic Purpura (ITP) would help to diagnose and treat early, and lessen parental anxiety.
VL  - 2
IS  - 1
ER  -

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Author Information

Mikel Koti

Service of General Pediatric Clinic, “Omer Nishani” Hospital, Gjirokaster, Albania
Edmond Kotoni

Service of General Pediatric Clinic, “Omer Nishani” Hospital, Gjirokaster, Albania
Anthulla Kajo

Service of General Pediatric Clinic, “Omer Nishani” Hospital, Gjirokaster, Albania
Asife Shehaj

Service of General Pediatric Clinic, “Omer Nishani” Hospital, Gjirokaster, Albania
Flasilda Brahimi

Service of General Pediatric Clinic, “Omer Nishani” Hospital, Gjirokaster, Albania

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APA Style

Mikel Koti, Edmond Kotoni, Anthulla Kajo, Asife Shehaj, Flasilda Brahimi. (2023). A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster. International Journal of Medical Case Reports, 2(1), 5-7. https://doi.org/10.11648/j.ijmcr.20230201.12

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ACS Style

Mikel Koti; Edmond Kotoni; Anthulla Kajo; Asife Shehaj; Flasilda Brahimi. A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster. Int. J. Med. Case Rep. 2023, 2(1), 5-7. doi: 10.11648/j.ijmcr.20230201.12

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AMA Style

Mikel Koti, Edmond Kotoni, Anthulla Kajo, Asife Shehaj, Flasilda Brahimi. A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster. Int J Med Case Rep. 2023;2(1):5-7. doi: 10.11648/j.ijmcr.20230201.12

Copy | Download

@article{10.11648/j.ijmcr.20230201.12,
  author = {Mikel Koti and Edmond Kotoni and Anthulla Kajo and Asife Shehaj and Flasilda Brahimi},
  title = {A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster},
  journal = {International Journal of Medical Case Reports},
  volume = {2},
  number = {1},
  pages = {5-7},
  doi = {10.11648/j.ijmcr.20230201.12},
  url = {https://doi.org/10.11648/j.ijmcr.20230201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmcr.20230201.12},
  abstract = {Acquired platelet dysfunction with eosinophilia (APDE) first reported in 1975 is an acquired, transient bleeding disorder of unknown etiology characterized by spontaneous ecchymosis, eosinophilia and platelet dysfunction. This bleeding disorder, otherwise known as “non-thrombocytopenic purpura with eosinophilia”, occurs commonly in indigenous Southeast Asian children. Cases of APDE occur rarely outside this endemic area. This syndrome runs a benign course and patients can recuperate spontaneously from the bleeding episodes within 6 months to a year. The aim of our case report is to highlight the importance of recognizing this little known bleeding disorder in our daily clinical practice. We reported the first documented case of a 7 year old girl managed in our hospital “Omer Nishani”, with clinical features characteristic of APDE. The patient was in good health, presented with spontaneous bruising on the extremities with no organomegaly. Marked eosinophilia and prolonged bleeding time with normal platelet count were noted on laboratory work-up. The patient was started on antiparasitic therapy despite negative stool results, and subsequent follow-up after 3 weeks showed resolution of ecchymosis and eosinophilia. Awareness of this benign bleeding disorder, which clinically mimics Idiopathic Thrombocytopenic Purpura (ITP) would help to diagnose and treat early, and lessen parental anxiety.},
 year = {2023}
}

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TY  - JOUR
T1  - A Case of Acquired Platelet Dysfunction with Eosinophilia in Our Hospital “Omer Nishani”, Gjirokaster
AU  - Mikel Koti
AU  - Edmond Kotoni
AU  - Anthulla Kajo
AU  - Asife Shehaj
AU  - Flasilda Brahimi
Y1  - 2023/01/31
PY  - 2023
N1  - https://doi.org/10.11648/j.ijmcr.20230201.12
DO  - 10.11648/j.ijmcr.20230201.12
T2  - International Journal of Medical Case Reports
JF  - International Journal of Medical Case Reports
JO  - International Journal of Medical Case Reports
SP  - 5
EP  - 7
PB  - Science Publishing Group
SN  - 2994-7049
UR  - https://doi.org/10.11648/j.ijmcr.20230201.12
AB  - Acquired platelet dysfunction with eosinophilia (APDE) first reported in 1975 is an acquired, transient bleeding disorder of unknown etiology characterized by spontaneous ecchymosis, eosinophilia and platelet dysfunction. This bleeding disorder, otherwise known as “non-thrombocytopenic purpura with eosinophilia”, occurs commonly in indigenous Southeast Asian children. Cases of APDE occur rarely outside this endemic area. This syndrome runs a benign course and patients can recuperate spontaneously from the bleeding episodes within 6 months to a year. The aim of our case report is to highlight the importance of recognizing this little known bleeding disorder in our daily clinical practice. We reported the first documented case of a 7 year old girl managed in our hospital “Omer Nishani”, with clinical features characteristic of APDE. The patient was in good health, presented with spontaneous bruising on the extremities with no organomegaly. Marked eosinophilia and prolonged bleeding time with normal platelet count were noted on laboratory work-up. The patient was started on antiparasitic therapy despite negative stool results, and subsequent follow-up after 3 weeks showed resolution of ecchymosis and eosinophilia. Awareness of this benign bleeding disorder, which clinically mimics Idiopathic Thrombocytopenic Purpura (ITP) would help to diagnose and treat early, and lessen parental anxiety.
VL  - 2
IS  - 1
ER  -

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