Case Report
Renal Biopsy Revealing an Unusual Pathogen in a Case of Renal Dysfunction: A Case Report
Shemeera Saidalavi Vellolipadikkal*
,
Meeta Thomas
Issue:
Volume 5, Issue 3, September 2026
Pages:
24-27
Received:
14 March 2026
Accepted:
25 March 2026
Published:
22 July 2026
DOI:
10.11648/j.ijmcr.20260503.11
Downloads:
Views:
Abstract: Background: Invasive fungal pyelonephritis is a rare but potentially life-threatening renal infection, predominantly affecting immunocompromised or critically ill individuals. The diagnosis is often delayed due to nonspecific clinical presentation and laboratory findings, which can lead to adverse renal outcomes. Objective: To highlight the diagnostic challenges and emphasize the role of renal biopsy in identifying invasive fungal infections of the kidney. Methods/Case Presentation: We report the case of a 75-year-old male with a history of diabetes mellitus and recent nonsteroidal anti-inflammatory drug–induced acute kidney injury, who presented with persistent renal dysfunction and pancytopenia. Despite supportive management, renal parameters failed to improve, prompting a renal biopsy. Histopathological examination revealed extensive neutrophilic tubulitis and abscess formation. Fungal elements were identified on special stains, confirming invasive fungal infection. Subsequent urine culture grew Candida tropicalis, establishing the etiological diagnosis. Results: The integration of histopathology and microbiological findings enabled timely diagnosis of invasive fungal pyelonephritis in an otherwise diagnostically challenging clinical scenario. Conclusion: This case underscores the importance of considering fungal infections in patients with unexplained renal dysfunction, particularly in the presence of risk factors such as diabetes and recent renal injury. Early renal biopsy and prompt antifungal therapy are crucial to prevent irreversible renal damage and improve patient outcomes.
Abstract: Background: Invasive fungal pyelonephritis is a rare but potentially life-threatening renal infection, predominantly affecting immunocompromised or critically ill individuals. The diagnosis is often delayed due to nonspecific clinical presentation and laboratory findings, which can lead to adverse renal outcomes. Objective: To highlight the diagnos...
Show More
