Abstract: The paper assessed the issues and challenges to availability and accessibility of CD-ROM and Online Databases in public university libraries in Cross River State in the South-south, Nigeria. The paper discussed the concept of CD-ROM and Online Databases. The paper further highlighted the issues and challenges to availability and accessibility of CD-ROM and Online Databases in Nigerian university libraries. The survey design was adopted for the study. Questionnaire was used to collect the data. Tables and percentage were used in the analysis. The study was carried out in Cross River State in the South-south, Nigeria where 91 librarians in federal and state owned public universities were used for the study. The paper concluded that the issues and challenges to availability and accessibility of CD-ROM and Online Databases are anchored to a large extent on underfunding of university libraries, epileptic power supply, poor telecommunication and Internet facilities, and lack of ICT skills among librarians, among others. The paper recommended that the level of funding/financial support to university libraries by both state and federal should be reviewed upward to enhance the procurement of modern CD-ROM and Online databases for the provision of library services to users, Library management should adopt CD-ROM and Online databases in libraries as well as exhibit a maintenance culture of equipment, Library management in these libraries should fully embrace and utilise ICT in their libraries to provide quality services to their clientele since computers and other ICT facilities reputably provide quick access to relevant information both within and outside the library, among others. Moreover, librarians who cannot use computer and Internet-based technologies to deliver services become obsolete in the future.Abstract: The paper assessed the issues and challenges to availability and accessibility of CD-ROM and Online Databases in public university libraries in Cross River State in the South-south, Nigeria. The paper discussed the concept of CD-ROM and Online Databases. The paper further highlighted the issues and challenges to availability and accessibility of CD...Show More