Abstract: It is well known that furans derivatives have high biological activities and commercialized furans compounds have extensive applications in life science and medicine field, however, the studies on its potential fungicidal activities are rare and lack of reports. In order to find novel candidate compounds with high fungicidal efficiency, a series of furans derivatives were synthesized and their fungicidal activities were evaluated, which provides information for molecular design and modification of furans compounds with highly effective broad-spectrum fungicidal activities. A series of novel 1,2,3,4-substituted-furans derivatives were synthesized by one-pot method and the structures were confirmed by 1H NMR and 13C NMR. The fungicidal activities were evaluated by the mycelium growth rate method in vitro. Compound c7, c14, c15, c17 and c18 against Fusarium oxysporum had comparable activities with chlorothalonil. Among them, compound c14 and c15 against F. oxysporum with EC50 value of 14.71 mg/L and 14.39 mg/L, respectively, which were superior to that of chlorothalonil. Dimethyl 5-methyl-4-(2-phenylethynyl) furan-2,3-dicarboxylate deserved further development as one kind of novel promising fungicidal agents.Abstract: It is well known that furans derivatives have high biological activities and commercialized furans compounds have extensive applications in life science and medicine field, however, the studies on its potential fungicidal activities are rare and lack of reports. In order to find novel candidate compounds with high fungicidal efficiency, a series of...Show More