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Primary Intraspinal Extradural Hydatid Cyst of the Dorsal Region: A Case Report
Mouhibe Hanane,
El Mezouari El Mostafa,
Redouane Rhoukhsi,
Redouane Moutaj
Issue:
Volume 2, Issue 1, June 2018
Pages:
1-4
Received:
7 January 2017
Accepted:
27 April 2017
Published:
7 May 2018
Abstract: Primarily extradural localization is exceptional posing problems of differential diagnosis even in hydatid endemic countries. We report a case of primary intraspinal extradural hydatid cyst of the dorsal region causing spinal cord compression. The 12-year-old child, living in a rural area with no significant antecedent, presented with gradually increasing three months before his hospitalization a dorsal and lumbarpain installat. He also complained a few days later of numbness and altered sensations in both legs and sphincter disorders. Clinical examination has demonstrated a syndrome of spinal cord compression. Abdominal ultrasound was normal. The diagnosis was an extradural abscess, a dysembryoplastic lesion, or a hydatid localization. A surgical approach was performed in an emergency, consisting of a posterior decompression by laminotomy centered on D12, which resulted in total resection of the cyst repressing and stretching the right root back and the left dural sheath whose hydatid nature was presumptive and confirmed by final histological examination. The immediate consequences were simple.
Abstract: Primarily extradural localization is exceptional posing problems of differential diagnosis even in hydatid endemic countries. We report a case of primary intraspinal extradural hydatid cyst of the dorsal region causing spinal cord compression. The 12-year-old child, living in a rural area with no significant antecedent, presented with gradually inc...
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Abo Blood Variants of Selected Babcock University Students and Their Link with Malaria Parasitaemia
Otajevwo Festus Dafinone,
Owodunni Olasope Mumeen
Issue:
Volume 2, Issue 1, June 2018
Pages:
5-14
Received:
16 March 2017
Accepted:
28 April 2017
Published:
9 May 2018
Abstract: Five milliliters (5ml) of venous whole blood was collected from one hundred and eighty three students made up of 93(50.8%) male and 90(49.2%) female students of Babcock University, Ilishan Remo randomly selected across various Departments. Whole blood samples were dispensed into sequestrinized (EDTA anticoagulated) blood containers, properly mixed and labeled. Malaria Plasmodium falciparum parasite screening was done semi-quantitatively by Field stain A and B staining. ABO blood phenotyping was carried out with monoclonal Antisera A, B and D. A total of 169 (92.3%) and 14(7.7%) students were rhesus positive and negative respectively of which 92(54.4%) and 77(45.6%) samples were rhesus positive male and female students respectively and of which 1(7.1%) and 13(92.9%) students were rhesus negative male and female students respectively. One hundred and thirty five (73.8%), 36(19.7%) and 12(6.5%) of the sampled student population belonged to 17-20, 21-24 and 25-30yr age brackets respectively. One hundred and ten (60.1%), 38(20.8%), 29(15.9%) and 6(3.3%) students were of O, A, B and AB blood phenotypes respectively. Out of the 183 blood samples obtained from 93 (50.8%) and 90(49.2%) male and female students respectively, 126(68.9%) students were infected with P. falciparum malaria parasites. More males were infected than females and were significantly associated with malaria infection (X2 0.05, 1 =3.841, Cal. X2 =25.253, P˂0.05). Also, out of the 68.9% infected students, 47(37.3%) and 79(62.7%) had severe and non-severe forms of malaria infection respectively. Severe malaria frequency occurrences were 85.0%, 70.6%, 50.0% and 50.0% for blood types A, O, B and AB respectively while non-severe malaria frequency occurrences were 83.3%, 75.0%, 65.8% and 57.9% with respect to blood types A, AB O and B respectively. ABO blood types especially type A were significantly associated with severe form of P. falciparum malaria infection (X20.05, 3=7.815, X20.01, 3=11.350, Cal. X2 =284.601 and P˂0.05, P˂0.01). ABO blood types were also significantly associated with non-severe form of malaria especially type A (Cal. X2 =230.768 and hence, P˂0.05, P˂0.01). Implications of rising trend of rhesus negative factor in female students, population variations in association with ABO blood types and malaria parasitaemia are discussed.
Abstract: Five milliliters (5ml) of venous whole blood was collected from one hundred and eighty three students made up of 93(50.8%) male and 90(49.2%) female students of Babcock University, Ilishan Remo randomly selected across various Departments. Whole blood samples were dispensed into sequestrinized (EDTA anticoagulated) blood containers, properly mixed ...
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FOXM 1 Expression in Breast Carcinoma and Correlation with Histopathological Staging and Grading
Rafah Mohamed Jaffar Alkhateeb,
Salim Rasheed Alaubaidy
Issue:
Volume 2, Issue 1, June 2018
Pages:
15-19
Received:
13 March 2018
Accepted:
11 April 2018
Published:
17 May 2018
Abstract: FOXM1 (Forkhead box protein M1) promoted EMT (Epithelial-to-mesenchymal transition) in breast cancer by binding and activation of the promoter of SLUG gene. that FOXM1 promotes breast cancer metastases by activation of the TGF-β pathway with through interaction SMAD3 (this prevented E3 ubiquitin-protein ligase transcriptional intermediary factor 1 γ [TIF1 γ] binding to SMAD3 and protected SMAD4 from ubiquitination) that leads to stabilization of the SMAD3/SMAD4 complex. The study samples included seventy four formalin-fixed, paraffin embedded tissue blocks which have been diagnosed as forty four cases of breast carcinoma and their lymph nodes. In the present study from 74 total cases, 46 cases (62.6%) were showing FOXM1 marker positive while 28 cases (37.8%) were showing negative immunohistochemistry for FOXM1 marker. Sub classification of malignant cases, 16 malignant breast cancer cases (36.4%) showed no FOXM1 expression, while 12 malignant cases (27.3%) were strongly positive for FOXM1 expression. There is significant correlation between breast carcinoma grade, stage and FOXM1 expression.
Abstract: FOXM1 (Forkhead box protein M1) promoted EMT (Epithelial-to-mesenchymal transition) in breast cancer by binding and activation of the promoter of SLUG gene. that FOXM1 promotes breast cancer metastases by activation of the TGF-β pathway with through interaction SMAD3 (this prevented E3 ubiquitin-protein ligase transcriptional intermediary factor 1 ...
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Prevalence of Epstein–Barr Virus in Patients with Ulcerative Colitis Using Polymerase Chain Reaction (PCR)
Maryam Derakhshan,
Pegah Hedayat,
Rozhan Mohammadi,
Amirsajad Barahimi
Issue:
Volume 2, Issue 1, June 2018
Pages:
20-24
Received:
22 June 2018
Accepted:
3 August 2018
Published:
10 September 2018
Abstract: Ulcerative colitis (UC) is still controversial and recent researches referred to the role of infectious factors such as EBV in this disease, but the relationship between EBV and UC has not yet been proven. Therefore, the present study evaluates the prevalence of EBV in patients with UC and comparison with control group by Polymerase Chain Reaction (PCR). In this study, 30 samples of intestinal biopsy in patients with UC in the active phase of disease and 30 biopsy samples from non-UC subjects were evaluated by PCR method were evaluated by PCR method and the presence or absence of EBV virus in the sample was recorded. Finally, the collected data were analyzed by SPSS (Ver.22) software. As the result EBV was found in 10 biopsies of 30 from UC patients and 3 of 30 biopsies from non-UC-patients (33.3% vs. 10%, P-value = 0.028). Also, the prevalence of this virus in the both groups was not significantly different in terms of sex and age (P-value > 0.05). Therefore, it may conclude that evidence of infection of the virus in mucosal inflammatory cells of patients with UC has an important role in chronic UC. Given the small sample size, it is suggested that future studies to be carried out with similar subject in a larger population of these patients.
Abstract: Ulcerative colitis (UC) is still controversial and recent researches referred to the role of infectious factors such as EBV in this disease, but the relationship between EBV and UC has not yet been proven. Therefore, the present study evaluates the prevalence of EBV in patients with UC and comparison with control group by Polymerase Chain Reaction ...
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Epidemiology of Amoebas in Marrakech (Morocco): Experience of Parasitology Service from the Military Hospital Avicenne
Mouayche Ikhlas,
Moutaj Redouane,
El Mezouari El Mostafa
Issue:
Volume 2, Issue 1, June 2018
Pages:
25-29
Received:
15 August 2018
Accepted:
5 September 2018
Published:
27 September 2018
Abstract: Amoebiasis is the third leading cause of parasite mortality and morbidity worldwide and still remains a serious public health problem today. In order to determine the epidemiological profile of amoebae and intestinal amoebiasis in the population of Marrakech. This is a prospective study on the results of parasitological examinations of stool (EPS) performed in adults and children in the department of Parasitology Mycology at the Military Hospital Avicenne (HMA) of Marrakech over a period of two months from 1 May 2018 to 30 June 2018. 70 parasitological examinations of stool (EPS) were performed. Of the 38 positive samples 71.05% were male with a sex M / F ratio of 2.08. Each patient received at least one EPS, including fresh reading, after Lugol staining, and finally after concentration by the Willis and Ritchie technique. Among the parasites encountered, after identification of the species, the percentage of Blastocystis hominis is 45.76% followed by Entamoeba coli 35.59%, followed by Chilomastix mesnili 10.17% then Entamoeba histolytica histolytica and Entamoeba histolytica minuta, the latter having the same proportion 3.39% and in late Giardia intestinalis with a low proportion of 1.69%. Amoeba remains, even today, a real public health problem. For example, broadening the scope of these studies by similar surveys focusing on the rural environment would be desirable.
Abstract: Amoebiasis is the third leading cause of parasite mortality and morbidity worldwide and still remains a serious public health problem today. In order to determine the epidemiological profile of amoebae and intestinal amoebiasis in the population of Marrakech. This is a prospective study on the results of parasitological examinations of stool (EPS) ...
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