Research Article
Exploring the Therapeutic Potential of Common Sweeteners Through Cell Viability, Antioxidant, and Antibacterial Evaluations
Rojina Khatun
,
Sudeshna Sengupta,
Dipanshu Mondal,
Anuradha Paria,
Subhamay Mukherjee,
Sriparna Roy,
Arshi Akhtar,
Sabuj Chakraborty,
Disha Das,
Agnidipta Sarkar,
Malavika Bhattacharya*
Issue:
Volume 14, Issue 1, June 2026
Pages:
1-19
Received:
11 March 2026
Accepted:
20 March 2026
Published:
2 April 2026
DOI:
10.11648/j.cb.20261401.11
Downloads:
Views:
Abstract: Sweeteners are generally used in food and pharmaceutical formulations, yet their natural conditioning beyond taste isn't well understood. This study explores the remedial eventuality of four extensively used sweeteners, sucrose, lactose, mannitol, and dextrose, focusing on their cytotoxic, antioxidant, and antibacterial properties. Cytotoxicity was assessed using the MTT assay in a mammalian macrophage cell line at colourful attention (0.2 – 6). Both lactose and dextrose enhanced cell viability by 25 – 30 at lower boluses, indicating cytoprotective goods. In discrepancy, mannitol significantly reduced cell viability by over 40 at advanced attention, suggesting cytotoxicity. The antioxidant capacity of the sweeteners was estimated with the DPPH and potassium permanganate assays, revealing that sucrose displayed the loftiest radical-scavenging activity (up to 80), showcasing notable redox-modulating potential. In terms of antibacterial exertion, assessed through the slice prolixity system, lactose demonstrated the most significant inhibition against Escherichia coli, producing the largest inhibition zone measuring 15 ± 1 mm. These findings indicate that common sweeteners retain distinct bioactivities that impact cell survival, oxidative balance, and microbial inhibition. The results emphasise the significance of recognising sweeteners not solely for their taste but also for their implicit remedial, nutraceutical, and preservative roles. This exploration opens avenues for further disquisition into the broader operations of sweeteners in health and drug.
Abstract: Sweeteners are generally used in food and pharmaceutical formulations, yet their natural conditioning beyond taste isn't well understood. This study explores the remedial eventuality of four extensively used sweeteners, sucrose, lactose, mannitol, and dextrose, focusing on their cytotoxic, antioxidant, and antibacterial properties. Cytotoxicity was...
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