Research Article
Study on the Structural and Physicochemical Characteristics of Newly Synthesized Compounds Based on Menthol-Derived Amino Acids
Lolakhon Ettibaeva*
,
Muxlisa Turdibekova,
Rayxona Ashiralieva
Issue:
Volume 13, Issue 3, September 2025
Pages:
36-40
Received:
27 March 2025
Accepted:
7 April 2025
Published:
2 September 2025
DOI:
10.11648/j.jctr.20251303.11
Downloads:
Views:
Abstract: This article discusses the optimized conditions for synthesizing novel menthol derivatives through its interaction with selected amino acids. This study presents the optimized conditions for synthesizing novel menthol derivatives through reactions with selected amino acids. The resulting compounds were characterized to determine their physicochemical properties, including appearance, aggregate state, and melting point. Notable variations in these characteristics suggest distinct structural and thermal behaviors among the synthesized derivatives. These findings imply potential applications in pharmaceuticals, materials science, and other related fields. The physical constants of the new compounds were determined, and their structures were analyzed using infrared (IR) and mass spectrometry. In the IR spectra of the complex esters, the absence of the hydroxyl (-OH) stretching vibration near 3245 cm⁻¹ confirms ester formation between the hydroxyl group of menthol and the amino acid moieties. These spectral features support the successful synthesis of complex esters and highlight the interaction mechanism. This work contributes to the development of functionalized organic molecules with promising physicochemical and possibly biological properties.
Abstract: This article discusses the optimized conditions for synthesizing novel menthol derivatives through its interaction with selected amino acids. This study presents the optimized conditions for synthesizing novel menthol derivatives through reactions with selected amino acids. The resulting compounds were characterized to determine their physicochemic...
Show More
Research Article
Safe Cholecystectomy as a Competency-based Teaching Method to Prevent Bile Duct Disruption
Juan Hernandez Orduña*
Issue:
Volume 13, Issue 3, September 2025
Pages:
41-51
Received:
5 December 2024
Accepted:
17 December 2024
Published:
3 September 2025
DOI:
10.11648/j.jctr.20251303.22
Downloads:
Views:
Abstract: Despite the benefits of laparoscopic cholecystectomy, the incidence of bile duct disruption has increased significantly over the years, from a range of 0.1 to 0.2% during the open cholecystectomy (CA) era to a range of 0.4 to 0.6% in the laparoscopic cholecystectomy (LC) era. and 0.72% per year in single-port cholecystectomy. Most prevention or safety interventions alone have not achieved adequate implementation and outcomes in terms of bile duct injury have remained largely unchanged. Nothing could be further from the truth than trying to establish infallible formulas for the prevention of surgical injuries of the bile duct. Bile duct injury secondary to cholecystectomy is one of the most catastrophic complications for both the patient and the surgeon due to its repercussions. The main factor in addressing this problem is prevention, performing gentle and careful surgical technique, recognizing when the situation is beyond the surgeon's ability, and being vigilant to ask for experienced help. It must be recognized that the latter and the decision to convert are not signs of incapacity, but of good judgment. Perhaps one of the most important principles is to keep in mind that any surgeon can present them. Only from this premise can the recommendations of the 10 high safety requirements and the 7 transoperative maneuvers for a safe cholecystectomy be useful, which together with a structured and competency-based teaching-learning process can further reduce the rate of surgical disruption of the bile duct.
Abstract: Despite the benefits of laparoscopic cholecystectomy, the incidence of bile duct disruption has increased significantly over the years, from a range of 0.1 to 0.2% during the open cholecystectomy (CA) era to a range of 0.4 to 0.6% in the laparoscopic cholecystectomy (LC) era. and 0.72% per year in single-port cholecystectomy. Most prevention or saf...
Show More
