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Investigation and Analysis of the Information Available for Pregnant Women in 1102 Antibiotic Package Inserts
Shaoli Tang,
Jiawen Huang,
Zhidong Zhang,
Jufeng Li,
Xiaofei Feng
Issue:
Volume 4, Issue 2, June 2020
Pages:
16-20
Received:
26 April 2020
Accepted:
11 May 2020
Published:
15 May 2020
Abstract: Objective To understand the current status of information on use by pregnant women in antibiotic package inserts. Methods Information related to use by pregnant women, was obtained from the package inserts of 66 commercially available antibiotics and was investigated and analyzed. The drugs were classified as follows according to their pharmacological effects: penicillins; first-, second-, third-, and fourth-generation cephalosporins; cephamycins; aminoglycosides; macrolides; tetracyclines; lincosamides; glycopeptide antibiotics; carbapenems; third- and fourth-generation quinolones; sulfonamides; and nitroimidazoles. Results A total of 1102 package inserts of 66 common commercially available antibiotics were obtained. Among them, 72.14% (795) package inserts included labels with advice for pregnant women, backed by relevant research data, whereas 23.23% (256) included labeling on the use by pregnant women without such experimental or relevant research data. In addition, 2.00% (22) of these inserts included unclear information, whereas the information was missing in 2.63% (29). Finally, 10.60% (7) of the package inserts contained contradictory information across manufacturers. Package inserts of some antibiotics are either not standardized or lack relevant information for use of these drugs by pregnant women, making it difficult to meet the needs of users and ensure medication safety. Conclusion Standardized management of drug package inserts must thus be enhanced.
Abstract: Objective To understand the current status of information on use by pregnant women in antibiotic package inserts. Methods Information related to use by pregnant women, was obtained from the package inserts of 66 commercially available antibiotics and was investigated and analyzed. The drugs were classified as follows according to their pharmacologi...
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The Effects of Gehuajiecheng Decoction on Expression of COX-2, Serum Level of PGE2, TNF-α and IL-6 in Alcoholic Hepatitis
Zhiwei Qu,
Wenbo Ju,
Aihua Ren,
Maoyang Liu
Issue:
Volume 4, Issue 2, June 2020
Pages:
21-26
Received:
22 April 2020
Accepted:
15 May 2020
Published:
29 May 2020
Abstract: Background: In this experimental study, we have researched Gehuajiecheng decoction mechanism of action in the treatment of alcoholic hepatitis so as to supply an effective drug in clinical practice. Methods: 40 male Wistar rats were randomly divided into 4 groups and treated with different drugs. The control group were given intragastric administration of corn oil (2g/kg/per day) and 50% glucose (20ml/kg/per day); the model group were given intragastric administration of 40% alcohol (8g/kg/per day) and corn oil (2g/kg/per day); Gehuajiecheng decoction group were given intragastric administration of Gehuajiecheng decoction (13g/kg/per day) and 40% alcohol (8g/kg/per day); the Celecoxib group were given intragastric administration of celecoxib (10mg/kg/per day) and 40% alcohol (8g/kg/per day). 30 days after treatment, the rats were anesthetized with sodium pentobarbital and the blood was collected. Serum levels of AST, ALT and GGT were measured by using chromatometry, PGE2, TNF-α and IL-6 levels were examined by using radioimmunology method. After taking blood samples, the rats were sacrificed, and the liver was determined by Western blotting analysis. Results: Compared to controls, model group showed significantly higher levels of serum AST, ALT, GGT, PGE2, TNF-α and IL-6, which can be corrected by administration of Gehuajiecheng decoction or celecoxib, since the group treated with Gehuajiecheng decoction or celecoxib showed significantly lower levels of serum AST, ALT, GGT, PGE2, TNF-α and IL-6 (p<0.01). However, liver function and Inflammatory mediators in Gehuajiecheng decoction were not significantly lower than that of the celecoxib group (p>0.05). Similarly, COX-2 expression in the model group was significantly higher than that of controls. However, its expression can be depleted by Gehuajiecheng decoction or celecoxib as COX-2 expression in the model groups (p<0.01). Conclusion: Gehuajiecheng decoction protects against alcohol-induced liver injuries via inhibiting expression of COX-2, decreasing release of PGE2, TNF-α and IL-6. It has the same effect as COX-2 selective inhibitor, therefore, we suggest that this decoction could be used as an effective method in the treatment of alcoholic hepatitis.
Abstract: Background: In this experimental study, we have researched Gehuajiecheng decoction mechanism of action in the treatment of alcoholic hepatitis so as to supply an effective drug in clinical practice. Methods: 40 male Wistar rats were randomly divided into 4 groups and treated with different drugs. The control group were given intragastric administra...
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Case Report: Treating Cryptococcal Meningoencephalitis with Chinese Herbal Medicine Based on Macro Natural Law of Traditional Chinese Medicine
Bian Wei,
Wang Huanqun,
Zou Weiwu,
Gan Ting
Issue:
Volume 4, Issue 2, June 2020
Pages:
27-31
Received:
20 May 2020
Accepted:
8 June 2020
Published:
20 June 2020
Abstract: Background: Over the past few decades, Expansion, Cryptococcus infection. Has become a worldwide Common fungal infections. Cryptococcus prevention has many difficulties in clinical application. Survivors Neurological sequelae are also common Cryptococcal Meningoencephal, CM. In China, Traditional Chinese Medicine tends to been used for poor fungal treatment or sequelae. Case presentation: We present a 47-year-old patient with cryptococcal encephalitis who’s clinical manifestations are atypical, and it is easy to misdiagnose. The first symptom was headache after tooth extraction, followed by fever. The diagnosis was confirmed 6 months after the onset of the disease. After antifungal treatment for 18 days, Headache and fever not reduced and multiple adverse effects such as impaired internal organs. The use of antifungal therapy has serious adverse reactions and poor treatment effects. When the disease is in critical condition, the modern medical antifungal treatment is ineffective and resistant to help. Using traditional Chinese medicine theory, it acknowledges the harmonious unity between man and nature, instead of looking for better resistance Fungal drugs, but by changing the internal environmental stability of the body, after 5 days of initial treatment, the patient no longer had fever, headache, snore, appetite restored and normal bowel movements, the nervous system function gradually recovers. No fever or headache occurred within 5 months, neurological function gradually recovered, head MRI improved, and cerebrospinal fluid culture was negative. After 7 months, the patient still had no fever, headache, snore, he can take care of himself, normal language expression can be done, farm work at home, one person can do food shopping and cooking, etc., limb muscle strength is normal, muscle tension is not high, No positive neurological examination. Conclusion: Traditional Chinese medicine modalities may be considered for treatment When western medicine treatment of cryptococcal encephalitis is not effective, based on appropriate syndrome pattern assessment.
Abstract: Background: Over the past few decades, Expansion, Cryptococcus infection. Has become a worldwide Common fungal infections. Cryptococcus prevention has many difficulties in clinical application. Survivors Neurological sequelae are also common Cryptococcal Meningoencephal, CM. In China, Traditional Chinese Medicine tends to been used for poor fungal ...
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Clinical Effects of Gu's Manipulation Combined with Functional Exercise After Endoscope Surgery for Knee Osteoarthropathy
Gu Xiaopeng,
Liu Yongtao,
Qi Junliang,
Shi Zhongyang,
Shu Weizhu,
Gu Yuequan
Issue:
Volume 4, Issue 2, June 2020
Pages:
32-36
Received:
25 May 2020
Accepted:
16 June 2020
Published:
28 June 2020
Abstract: To observe the effects of Gu's manipulation combined with progressive functional exercise method and simple progressive functional exercise method on the recovery of affected limb function after arthroscopic surgery for knee osteoarthropathy. Methods: A total of 98 patients with knee osteoarthropathy diagnosed in our department from January 2018 to January 2020 were randomly divided into simple progressive functional exercise method, the control group, with 49 cases of patients, and Gu's simple manipulation combined with progressive functional exercise method, the treatment group, with 49 cases of patients. Patients in both groups were routinely treated with subcutaneous arthroscopic dissection and meniscus trimming and suture with the ablation knife, and patients in both groups did not use external fixation after operation. The patients in the control group were given progressive functional exercise. In the manipulation group, the progressive functional exercise was combined with the guidance of simple manipulation therapy. Patients in both groups were discharged from the hospital on the 3rd day after surgery, and all received functional examination of the affected limb and knee WOMAC score on the 1st, 3rd, 7th, and 14th days after the surgery. Results: The comparison between the two groups showed that the patients in the treatment group had a significant reduction in pain 3 days after the surgery, swelling was significantly resolved, resting pain was improved, knee extension function and early walking stability were significantly improved; by the 14th day after surgery, the pain state of patients in the treatment group gradually tended to be consistent, but in the treatment group, the patients’ walking state, points of up and down stairs and activity difficulty scores were better than those in the control group. Conclusion: Gu's simple manipulation combined with progressive functional exercise can greatly promote the swelling of the affected limbs and functional recovery after knee arthroscopy. It is significantly better than simple progressive functional exercise. It is easy to operate and easy for patients to master and operate by themselves, so it is worthy to be popularized in patients with undergoing knee arthroscopy.
Abstract: To observe the effects of Gu's manipulation combined with progressive functional exercise method and simple progressive functional exercise method on the recovery of affected limb function after arthroscopic surgery for knee osteoarthropathy. Methods: A total of 98 patients with knee osteoarthropathy diagnosed in our department from January 2018 to...
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