This study evaluates the liver toxicity of three different herbal bitters (G. Winco, 1960 roots and Confam) on Wister albino rats. A total of 40 rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well ventilated room. Group A served as control and these rats were treated with distilled water. Wister albino rats in the groups B, C and D were treated with 3 different doses of the bitters (20, 30 and 40mL/Kgbw) respectively. The drugs were administered once daily for 10 and 21days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the results obtained. Alkaline phosphatase and aspartate transaminase was decreased in a non-dose dependent manner in this study. Alanine transaminase was elevated in a dose dependent manner. Histopathological changes were seen in all doses and duration of administration of confam. 1960 roots showed these changes with increasing duration of use and doses. These results further suggest that these bitters cause some degree of hepatic damage and should be used with care, in moderate amounts and with proper monitoring of liver function indices.
| Published in | Pharmaceutical Science and Technology (Volume 4, Issue 1) |
| DOI | 10.11648/j.pst.20200401.12 |
| Page(s) | 11-16 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2020. Published by Science Publishing Group |
Herbal Bitters, Hepatic Damage, Wister Albino Rats, Histopathological Changes
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APA Style
George Adieboye Oforibika, Diepiriye Adokiye Oforibika. (2020). Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats. Pharmaceutical Science and Technology, 4(1), 11-16. https://doi.org/10.11648/j.pst.20200401.12
ACS Style
George Adieboye Oforibika; Diepiriye Adokiye Oforibika. Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats. Pharm. Sci. Technol. 2020, 4(1), 11-16. doi: 10.11648/j.pst.20200401.12
AMA Style
George Adieboye Oforibika, Diepiriye Adokiye Oforibika. Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats. Pharm Sci Technol. 2020;4(1):11-16. doi: 10.11648/j.pst.20200401.12
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Download@article{10.11648/j.pst.20200401.12,
author = {George Adieboye Oforibika and Diepiriye Adokiye Oforibika},
title = {Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats},
journal = {Pharmaceutical Science and Technology},
volume = {4},
number = {1},
pages = {11-16},
doi = {10.11648/j.pst.20200401.12},
url = {https://doi.org/10.11648/j.pst.20200401.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20200401.12},
abstract = {This study evaluates the liver toxicity of three different herbal bitters (G. Winco, 1960 roots and Confam) on Wister albino rats. A total of 40 rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well ventilated room. Group A served as control and these rats were treated with distilled water. Wister albino rats in the groups B, C and D were treated with 3 different doses of the bitters (20, 30 and 40mL/Kgbw) respectively. The drugs were administered once daily for 10 and 21days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the results obtained. Alkaline phosphatase and aspartate transaminase was decreased in a non-dose dependent manner in this study. Alanine transaminase was elevated in a dose dependent manner. Histopathological changes were seen in all doses and duration of administration of confam. 1960 roots showed these changes with increasing duration of use and doses. These results further suggest that these bitters cause some degree of hepatic damage and should be used with care, in moderate amounts and with proper monitoring of liver function indices.},
year = {2020}
}
TY - JOUR T1 - Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats AU - George Adieboye Oforibika AU - Diepiriye Adokiye Oforibika Y1 - 2020/02/14 PY - 2020 N1 - https://doi.org/10.11648/j.pst.20200401.12 DO - 10.11648/j.pst.20200401.12 T2 - Pharmaceutical Science and Technology JF - Pharmaceutical Science and Technology JO - Pharmaceutical Science and Technology SP - 11 EP - 16 PB - Science Publishing Group SN - 2640-4540 UR - https://doi.org/10.11648/j.pst.20200401.12 AB - This study evaluates the liver toxicity of three different herbal bitters (G. Winco, 1960 roots and Confam) on Wister albino rats. A total of 40 rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well ventilated room. Group A served as control and these rats were treated with distilled water. Wister albino rats in the groups B, C and D were treated with 3 different doses of the bitters (20, 30 and 40mL/Kgbw) respectively. The drugs were administered once daily for 10 and 21days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the results obtained. Alkaline phosphatase and aspartate transaminase was decreased in a non-dose dependent manner in this study. Alanine transaminase was elevated in a dose dependent manner. Histopathological changes were seen in all doses and duration of administration of confam. 1960 roots showed these changes with increasing duration of use and doses. These results further suggest that these bitters cause some degree of hepatic damage and should be used with care, in moderate amounts and with proper monitoring of liver function indices. VL - 4 IS - 1 ER -
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