In this study, to comparatively evaluate whether aqueous extracts of G. sylvestre and D. metel induce acute dermal irritation and or contract wound tests were performed using experimental animals. The skin of the rats was treated with these extracts (0.5g/dose) and whether the animals sustained skin damage was determined by visual observation. The data demonstrated that the aqueous extracts of both plants did not induce acute skin irritation (toxicity) on the skin of the animals as assessed by pathological observations. Wound healing properties were evaluated using excision wound model. The groups of rats were experimentally wounded at the posterior neck area. An area of uniform wound of 7x7mm using millimetre rule was exercised from the dorsal back of the rats. The animal groups were topically treated with G. sylvestre and D. metel gels. Wound dressed with leaf, stem and flower of G. sylvestre and leaf, stem and fruit of D. metel gel significantly heal earlier than those treated with paraffin base, while the leaf and stem of G. sylvestre and leaf and fruit of D. metel healed wound better than povidone iodine. The results from the present study suggest that these aqueous extracts of G. sylvestre and D. metel have promising potential uses as cosmetic ingredients that do not induce significant levels of dermal irritation and exhibit wound healing properties. Wound contraction elicited by these plant parts in this investigation following topical administration strongly corroborates the verbal claims on their efficacy for these activities.
| Published in | American Journal of Biomedical and Life Sciences (Volume 2, Issue 4) |
| DOI | 10.11648/j.ajbls.20140204.14 |
| Page(s) | 83-88 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Gymnema Sylvestre, Datura Metel, Wound Contraction, Dermal Irritation, Rats
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APA Style
Omale James, Ajidahun Bidemi Sunday. (2014). Evaluation of Acute Dermal Irritation and Wound Contraction by Gymnema Sylvestre and Datura Metel Extracts in Rats. American Journal of Biomedical and Life Sciences, 2(4), 83-88. https://doi.org/10.11648/j.ajbls.20140204.14
ACS Style
Omale James; Ajidahun Bidemi Sunday. Evaluation of Acute Dermal Irritation and Wound Contraction by Gymnema Sylvestre and Datura Metel Extracts in Rats. Am. J. Biomed. Life Sci. 2014, 2(4), 83-88. doi: 10.11648/j.ajbls.20140204.14
AMA Style
Omale James, Ajidahun Bidemi Sunday. Evaluation of Acute Dermal Irritation and Wound Contraction by Gymnema Sylvestre and Datura Metel Extracts in Rats. Am J Biomed Life Sci. 2014;2(4):83-88. doi: 10.11648/j.ajbls.20140204.14
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Download@article{10.11648/j.ajbls.20140204.14,
author = {Omale James and Ajidahun Bidemi Sunday},
title = {Evaluation of Acute Dermal Irritation and Wound Contraction by Gymnema Sylvestre and Datura Metel Extracts in Rats},
journal = {American Journal of Biomedical and Life Sciences},
volume = {2},
number = {4},
pages = {83-88},
doi = {10.11648/j.ajbls.20140204.14},
url = {https://doi.org/10.11648/j.ajbls.20140204.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20140204.14},
abstract = {In this study, to comparatively evaluate whether aqueous extracts of G. sylvestre and D. metel induce acute dermal irritation and or contract wound tests were performed using experimental animals. The skin of the rats was treated with these extracts (0.5g/dose) and whether the animals sustained skin damage was determined by visual observation. The data demonstrated that the aqueous extracts of both plants did not induce acute skin irritation (toxicity) on the skin of the animals as assessed by pathological observations. Wound healing properties were evaluated using excision wound model. The groups of rats were experimentally wounded at the posterior neck area. An area of uniform wound of 7x7mm using millimetre rule was exercised from the dorsal back of the rats. The animal groups were topically treated with G. sylvestre and D. metel gels. Wound dressed with leaf, stem and flower of G. sylvestre and leaf, stem and fruit of D. metel gel significantly heal earlier than those treated with paraffin base, while the leaf and stem of G. sylvestre and leaf and fruit of D. metel healed wound better than povidone iodine. The results from the present study suggest that these aqueous extracts of G. sylvestre and D. metel have promising potential uses as cosmetic ingredients that do not induce significant levels of dermal irritation and exhibit wound healing properties. Wound contraction elicited by these plant parts in this investigation following topical administration strongly corroborates the verbal claims on their efficacy for these activities.},
year = {2014}
}
TY - JOUR T1 - Evaluation of Acute Dermal Irritation and Wound Contraction by Gymnema Sylvestre and Datura Metel Extracts in Rats AU - Omale James AU - Ajidahun Bidemi Sunday Y1 - 2014/08/30 PY - 2014 N1 - https://doi.org/10.11648/j.ajbls.20140204.14 DO - 10.11648/j.ajbls.20140204.14 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 83 EP - 88 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20140204.14 AB - In this study, to comparatively evaluate whether aqueous extracts of G. sylvestre and D. metel induce acute dermal irritation and or contract wound tests were performed using experimental animals. The skin of the rats was treated with these extracts (0.5g/dose) and whether the animals sustained skin damage was determined by visual observation. The data demonstrated that the aqueous extracts of both plants did not induce acute skin irritation (toxicity) on the skin of the animals as assessed by pathological observations. Wound healing properties were evaluated using excision wound model. The groups of rats were experimentally wounded at the posterior neck area. An area of uniform wound of 7x7mm using millimetre rule was exercised from the dorsal back of the rats. The animal groups were topically treated with G. sylvestre and D. metel gels. Wound dressed with leaf, stem and flower of G. sylvestre and leaf, stem and fruit of D. metel gel significantly heal earlier than those treated with paraffin base, while the leaf and stem of G. sylvestre and leaf and fruit of D. metel healed wound better than povidone iodine. The results from the present study suggest that these aqueous extracts of G. sylvestre and D. metel have promising potential uses as cosmetic ingredients that do not induce significant levels of dermal irritation and exhibit wound healing properties. Wound contraction elicited by these plant parts in this investigation following topical administration strongly corroborates the verbal claims on their efficacy for these activities. VL - 2 IS - 4 ER -
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