Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice

Muluken Walle; Bizuayehu Walle; Legesse Zerihun; Eyasu Makonnen

doi:doi:10.11648/j.ajbls.20140204.12

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Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice

Muluken Walle, Bizuayehu Walle, Legesse Zerihun, Eyasu Makonnen

Published in American Journal of Biomedical and Life Sciences (Volume 2, Issue 4)

Received: 14 July 2014 Accepted: 28 July 2014 Published: 10 August 2014

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Abstract

Myrtus communis has been recommended for relief of insomnia in Ethiopian traditional medicine and aromatherapy. However, no pharmacological studies have yet evaluated its sedative-hypnotic like effect. The aim of this study was to determine if the essential oil of Myrtus communis has sedative-hypnotic like activity. The essential oil of Myrtus communis (500,600, 800, and 1000 mg/kg) were administered orally to Swiss albino mice of both sex, 60 minutes before pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. More over the effect of the EO on motor-coordination and muscle relaxation were evaluated using Chimney and Traction test 60 and 90 min after administration of the respective doses of the EO respectively. The essential oil prolonged pentobarbital-induced sleeping time at 600, 800 (comparable to diazepam 3mg/kg), and at 1000 mg/kg compared to vehicle-treated group. The 50% negative response was observed on the Chimney and Traction test at 800 and 1000mg/kg respectively. The essential oil of Myrtus communis possesses dose dependent sedative-hypnotic like activity and CNS depressant activity.

Published in	American Journal of Biomedical and Life Sciences (Volume 2, Issue 4)
DOI	10.11648/j.ajbls.20140204.12
Page(s)	70-77
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Myrtus Communis, Sedative, Hypnotic, Motor Coordination, Muscle Relaxation, Essential Oil (EO)

References

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APA Style

Muluken Walle, Bizuayehu Walle, Legesse Zerihun, Eyasu Makonnen. (2014). Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. American Journal of Biomedical and Life Sciences, 2(4), 70-77. https://doi.org/10.11648/j.ajbls.20140204.12

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ACS Style

Muluken Walle; Bizuayehu Walle; Legesse Zerihun; Eyasu Makonnen. Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. Am. J. Biomed. Life Sci. 2014, 2(4), 70-77. doi: 10.11648/j.ajbls.20140204.12

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AMA Style

Muluken Walle, Bizuayehu Walle, Legesse Zerihun, Eyasu Makonnen. Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. Am J Biomed Life Sci. 2014;2(4):70-77. doi: 10.11648/j.ajbls.20140204.12

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@article{10.11648/j.ajbls.20140204.12,
  author = {Muluken Walle and Bizuayehu Walle and Legesse Zerihun and Eyasu Makonnen},
  title = {Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {2},
  number = {4},
  pages = {70-77},
  doi = {10.11648/j.ajbls.20140204.12},
  url = {https://doi.org/10.11648/j.ajbls.20140204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20140204.12},
  abstract = {Myrtus communis has been recommended for relief of insomnia in Ethiopian traditional medicine and aromatherapy. However, no pharmacological studies have yet evaluated its sedative-hypnotic like effect. The aim of this study was to determine if the essential oil of Myrtus communis has sedative-hypnotic like activity. The essential oil of Myrtus communis (500,600, 800, and 1000 mg/kg) were administered orally to Swiss albino mice of both sex, 60 minutes before pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. More over the effect of the EO on motor-coordination and muscle relaxation were evaluated using Chimney and Traction test 60 and 90 min after administration of the respective doses of the EO respectively. The essential oil prolonged pentobarbital-induced sleeping time at 600, 800 (comparable to diazepam 3mg/kg), and at 1000 mg/kg compared to vehicle-treated group. The 50% negative response was observed on the Chimney and Traction test at 800 and 1000mg/kg respectively. The essential oil of Myrtus communis possesses dose dependent sedative-hypnotic like activity and CNS depressant activity.},
 year = {2014}
}

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TY - JOUR
T1 - Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice
AU - Muluken Walle
AU - Bizuayehu Walle
AU - Legesse Zerihun
AU - Eyasu Makonnen
Y1 - 2014/08/10
PY - 2014
N1 - https://doi.org/10.11648/j.ajbls.20140204.12
DO - 10.11648/j.ajbls.20140204.12
T2 - American Journal of Biomedical and Life Sciences
JF - American Journal of Biomedical and Life Sciences
JO - American Journal of Biomedical and Life Sciences
SP - 70
EP - 77
PB - Science Publishing Group
SN - 2330-880X
UR - https://doi.org/10.11648/j.ajbls.20140204.12
AB - Myrtus communis has been recommended for relief of insomnia in Ethiopian traditional medicine and aromatherapy. However, no pharmacological studies have yet evaluated its sedative-hypnotic like effect. The aim of this study was to determine if the essential oil of Myrtus communis has sedative-hypnotic like activity. The essential oil of Myrtus communis (500,600, 800, and 1000 mg/kg) were administered orally to Swiss albino mice of both sex, 60 minutes before pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. More over the effect of the EO on motor-coordination and muscle relaxation were evaluated using Chimney and Traction test 60 and 90 min after administration of the respective doses of the EO respectively. The essential oil prolonged pentobarbital-induced sleeping time at 600, 800 (comparable to diazepam 3mg/kg), and at 1000 mg/kg compared to vehicle-treated group. The 50% negative response was observed on the Chimney and Traction test at 800 and 1000mg/kg respectively. The essential oil of Myrtus communis possesses dose dependent sedative-hypnotic like activity and CNS depressant activity.
VL - 2
IS - 4
ER -

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Author Information

Muluken Walle

Department of physiology, College of medicine and health sciences, BDU, Bahirdar, Ethiopia
Bizuayehu Walle

Department of physiology, College of medicine and health sciences, BDU, Bahirdar, Ethiopia
Legesse Zerihun

Department of Physiology, School of Medicine, AAU, Addis Ababa, Ethiopia
Eyasu Makonnen

Department of pharmacology, School of Medicine, AAU, Addis Ababa, Ethiopia

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APA Style

Muluken Walle, Bizuayehu Walle, Legesse Zerihun, Eyasu Makonnen. (2014). Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. American Journal of Biomedical and Life Sciences, 2(4), 70-77. https://doi.org/10.11648/j.ajbls.20140204.12

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ACS Style

Muluken Walle; Bizuayehu Walle; Legesse Zerihun; Eyasu Makonnen. Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. Am. J. Biomed. Life Sci. 2014, 2(4), 70-77. doi: 10.11648/j.ajbls.20140204.12

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AMA Style

Muluken Walle, Bizuayehu Walle, Legesse Zerihun, Eyasu Makonnen. Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. Am J Biomed Life Sci. 2014;2(4):70-77. doi: 10.11648/j.ajbls.20140204.12

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@article{10.11648/j.ajbls.20140204.12,
  author = {Muluken Walle and Bizuayehu Walle and Legesse Zerihun and Eyasu Makonnen},
  title = {Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {2},
  number = {4},
  pages = {70-77},
  doi = {10.11648/j.ajbls.20140204.12},
  url = {https://doi.org/10.11648/j.ajbls.20140204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20140204.12},
  abstract = {Myrtus communis has been recommended for relief of insomnia in Ethiopian traditional medicine and aromatherapy. However, no pharmacological studies have yet evaluated its sedative-hypnotic like effect. The aim of this study was to determine if the essential oil of Myrtus communis has sedative-hypnotic like activity. The essential oil of Myrtus communis (500,600, 800, and 1000 mg/kg) were administered orally to Swiss albino mice of both sex, 60 minutes before pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. More over the effect of the EO on motor-coordination and muscle relaxation were evaluated using Chimney and Traction test 60 and 90 min after administration of the respective doses of the EO respectively. The essential oil prolonged pentobarbital-induced sleeping time at 600, 800 (comparable to diazepam 3mg/kg), and at 1000 mg/kg compared to vehicle-treated group. The 50% negative response was observed on the Chimney and Traction test at 800 and 1000mg/kg respectively. The essential oil of Myrtus communis possesses dose dependent sedative-hypnotic like activity and CNS depressant activity.},
 year = {2014}
}

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