Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats

Oko Augustine Okpani; Nweke Friday Nwalo; Ugwu Okechukwu Ogbonnia; Ehihia Loveth Ude.

doi:doi:10.11648/j.ajbls.20130101.15

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Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats

Oko Augustine Okpani, Nweke Friday Nwalo, Ugwu Okechukwu Ogbonnia, Ehihia Loveth Ude.

Published in American Journal of Biomedical and Life Sciences (Volume 1, Issue 1)

Received: 20 May 2013 Published: 30 June 2013

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Abstract

A study on the prophylactic efficacy of a crude aqueous extract of the leaves of Morinda lucida on plasmodium falciparum was carried out using sixteen albino rats grouped into curative, suppressive, prophylactic and control ;A,B,C and D respectively. The rats were inoculated with the parasites and allowed for 21days before 2mls of the extract was administered to each of the rats in group A twice daily for 3days, and for group B, 2mls was administered just once, 3hours before scarifying them, while for group C, 2mls was given twice daily for 3days before inoculation with the parasites, but group D were not given the extract. The results showed that the extract cleared the parasites in group A rats and did not allow its growth in group C rats, but did not suppress it in group B rats, while the control showed the ability of the parasites surviving in the rats. There was a significant at (P< 0.05) weight loss by the rats in all the groups, following the inoculation of the parasite. It can be inferred therefore, that a crude aqueous extract of Morinda lucida has a prophylactic efficacy in addition to its curative activity against plasmodium parasites and could be used to mitigate the impact of plasmodium parasites.

Published in	American Journal of Biomedical and Life Sciences (Volume 1, Issue 1)
DOI	10.11648/j.ajbls.20130101.15
Page(s)	27-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Maleria, Morinda Lucida, Plasmodium Falciparum

References

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Oko Augustine Okpani, Nweke Friday Nwalo, Ugwu Okechukwu Ogbonnia, Ehihia Loveth Ude. (2013). Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats. American Journal of Biomedical and Life Sciences, 1(1), 27-31. https://doi.org/10.11648/j.ajbls.20130101.15

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ACS Style

Oko Augustine Okpani; Nweke Friday Nwalo; Ugwu Okechukwu Ogbonnia; Ehihia Loveth Ude. Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats. Am. J. Biomed. Life Sci. 2013, 1(1), 27-31. doi: 10.11648/j.ajbls.20130101.15

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AMA Style

Oko Augustine Okpani, Nweke Friday Nwalo, Ugwu Okechukwu Ogbonnia, Ehihia Loveth Ude. Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats. Am J Biomed Life Sci. 2013;1(1):27-31. doi: 10.11648/j.ajbls.20130101.15

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@article{10.11648/j.ajbls.20130101.15,
  author = {Oko Augustine Okpani and Nweke Friday Nwalo and Ugwu Okechukwu Ogbonnia and Ehihia Loveth Ude.},
  title = {Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {1},
  number = {1},
  pages = {27-31},
  doi = {10.11648/j.ajbls.20130101.15},
  url = {https://doi.org/10.11648/j.ajbls.20130101.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130101.15},
  abstract = {A study on the prophylactic efficacy of a crude aqueous extract of the leaves of Morinda lucida on plasmodium falciparum was carried out using sixteen albino rats grouped into curative, suppressive, prophylactic and control ;A,B,C and D  respectively. The rats were inoculated with the parasites and allowed for 21days before 2mls of the extract was administered to each of the rats in group A twice daily for 3days, and for group B, 2mls was administered just once, 3hours before scarifying them, while for group C, 2mls was given twice daily for 3days before inoculation with the parasites, but group D were not given the extract. The results showed that the extract cleared the parasites in group A rats and did not allow its growth in group C rats, but did not suppress it in group B rats, while the control showed the ability of the parasites surviving in the rats. There was a significant at (P< 0.05) weight loss by the rats in all the groups, following the inoculation of the parasite. It can be inferred therefore, that a crude aqueous extract of Morinda lucida has a prophylactic efficacy in addition to its curative activity against plasmodium parasites and could be used to mitigate the impact of plasmodium parasites.},
 year = {2013}
}

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TY  - JOUR
T1  - Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats
AU  - Oko Augustine Okpani
AU  - Nweke Friday Nwalo
AU  - Ugwu Okechukwu Ogbonnia
AU  - Ehihia Loveth Ude.
Y1  - 2013/06/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbls.20130101.15
DO  - 10.11648/j.ajbls.20130101.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 27
EP  - 31
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20130101.15
AB  - A study on the prophylactic efficacy of a crude aqueous extract of the leaves of Morinda lucida on plasmodium falciparum was carried out using sixteen albino rats grouped into curative, suppressive, prophylactic and control ;A,B,C and D  respectively. The rats were inoculated with the parasites and allowed for 21days before 2mls of the extract was administered to each of the rats in group A twice daily for 3days, and for group B, 2mls was administered just once, 3hours before scarifying them, while for group C, 2mls was given twice daily for 3days before inoculation with the parasites, but group D were not given the extract. The results showed that the extract cleared the parasites in group A rats and did not allow its growth in group C rats, but did not suppress it in group B rats, while the control showed the ability of the parasites surviving in the rats. There was a significant at (P< 0.05) weight loss by the rats in all the groups, following the inoculation of the parasite. It can be inferred therefore, that a crude aqueous extract of Morinda lucida has a prophylactic efficacy in addition to its curative activity against plasmodium parasites and could be used to mitigate the impact of plasmodium parasites.
VL  - 1
IS  - 1
ER  -

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Author Information

Oko Augustine Okpani

Department of Biotechnology, Ebonyi State University, Abakaliki, Nigeria
Nweke Friday Nwalo

Department of Biotechnology, Federal University, Ndufu Alike-Ikwo, Nigeria
Ugwu Okechukwu Ogbonnia

Department of Biochemistry, Ebonyi State University, Abakaliki, Nigeria
Ehihia Loveth Ude.

Department of Biochemistry, Ebonyi State University, Abakaliki, Nigeria

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Oko Augustine Okpani, Nweke Friday Nwalo, Ugwu Okechukwu Ogbonnia, Ehihia Loveth Ude. (2013). Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats. American Journal of Biomedical and Life Sciences, 1(1), 27-31. https://doi.org/10.11648/j.ajbls.20130101.15

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Oko Augustine Okpani; Nweke Friday Nwalo; Ugwu Okechukwu Ogbonnia; Ehihia Loveth Ude. Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats. Am. J. Biomed. Life Sci. 2013, 1(1), 27-31. doi: 10.11648/j.ajbls.20130101.15

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AMA Style

Oko Augustine Okpani, Nweke Friday Nwalo, Ugwu Okechukwu Ogbonnia, Ehihia Loveth Ude. Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats. Am J Biomed Life Sci. 2013;1(1):27-31. doi: 10.11648/j.ajbls.20130101.15

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@article{10.11648/j.ajbls.20130101.15,
  author = {Oko Augustine Okpani and Nweke Friday Nwalo and Ugwu Okechukwu Ogbonnia and Ehihia Loveth Ude.},
  title = {Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {1},
  number = {1},
  pages = {27-31},
  doi = {10.11648/j.ajbls.20130101.15},
  url = {https://doi.org/10.11648/j.ajbls.20130101.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130101.15},
  abstract = {A study on the prophylactic efficacy of a crude aqueous extract of the leaves of Morinda lucida on plasmodium falciparum was carried out using sixteen albino rats grouped into curative, suppressive, prophylactic and control ;A,B,C and D  respectively. The rats were inoculated with the parasites and allowed for 21days before 2mls of the extract was administered to each of the rats in group A twice daily for 3days, and for group B, 2mls was administered just once, 3hours before scarifying them, while for group C, 2mls was given twice daily for 3days before inoculation with the parasites, but group D were not given the extract. The results showed that the extract cleared the parasites in group A rats and did not allow its growth in group C rats, but did not suppress it in group B rats, while the control showed the ability of the parasites surviving in the rats. There was a significant at (P< 0.05) weight loss by the rats in all the groups, following the inoculation of the parasite. It can be inferred therefore, that a crude aqueous extract of Morinda lucida has a prophylactic efficacy in addition to its curative activity against plasmodium parasites and could be used to mitigate the impact of plasmodium parasites.},
 year = {2013}
}

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TY  - JOUR
T1  - Assessment of the Prophylactic Efficacy of a Crude Aqueous Extract of Morinda Lucida Leaves on Plasmodium Falciparum Infection of Albino Rats
AU  - Oko Augustine Okpani
AU  - Nweke Friday Nwalo
AU  - Ugwu Okechukwu Ogbonnia
AU  - Ehihia Loveth Ude.
Y1  - 2013/06/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbls.20130101.15
DO  - 10.11648/j.ajbls.20130101.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 27
EP  - 31
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20130101.15
AB  - A study on the prophylactic efficacy of a crude aqueous extract of the leaves of Morinda lucida on plasmodium falciparum was carried out using sixteen albino rats grouped into curative, suppressive, prophylactic and control ;A,B,C and D  respectively. The rats were inoculated with the parasites and allowed for 21days before 2mls of the extract was administered to each of the rats in group A twice daily for 3days, and for group B, 2mls was administered just once, 3hours before scarifying them, while for group C, 2mls was given twice daily for 3days before inoculation with the parasites, but group D were not given the extract. The results showed that the extract cleared the parasites in group A rats and did not allow its growth in group C rats, but did not suppress it in group B rats, while the control showed the ability of the parasites surviving in the rats. There was a significant at (P< 0.05) weight loss by the rats in all the groups, following the inoculation of the parasite. It can be inferred therefore, that a crude aqueous extract of Morinda lucida has a prophylactic efficacy in addition to its curative activity against plasmodium parasites and could be used to mitigate the impact of plasmodium parasites.
VL  - 1
IS  - 1
ER  -

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