Abstract: Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.Abstract: Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of ...Show More
