Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia

Tsegahun Asfaw; Demissew Shenkute; Mihret Tilahun; Nigus Zegeye

doi:doi:10.11648/j.jfmhc.20180401.11

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Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia

Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye

Published in Journal of Family Medicine and Health Care (Volume 4, Issue 1)

Received: 15 February 2018 Accepted: 27 March 2018 Published: 20 April 2018

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Abstract

Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.

Published in	Journal of Family Medicine and Health Care (Volume 4, Issue 1)
DOI	10.11648/j.jfmhc.20180401.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Children, Apparently Healthy, ASO Titers, Ethiopia

References

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[3]	Batzloff M, Yan H, Davies M, et al. Preclinical Evaluation of a Vaccine Based on Conseved Region of M protein that prevents group A Streptococcal Infection, Indian Journal of medical Research, 119suppl, 2004, 104-107.
[4]	Andrew CS, Suzanna V, Roselyn R, Joseph K. Michael B. Adam WJ, et al., Normal Ranges of Streptococcal Antibody Titers Are Similar Whether Streptococci Are Endemic to the Setting or Not. Clinical and Vaccine Immunology, Feb. 2009; 16 (5): 172-175.
[5]	Shet A and Kaplan EL. Clinical use and interpretation of group A streptococcal antibody tests: a practical approach for the pediatrician or primary care physician. Pediatr. Infect. Dis. J. 2002; 21:420-426.
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[7]	Klein GC, Baker CN, and Jones WL. “Upper limits of normal” antistreptolysin O and antideoxyribonuclease B titers. Appl. Microbiol. 1971, 21: 999-1001.
[8]	Wannamaker LW and Ayoub EM. Antibody titers in acute rheumatic fever. Circulation 1960; 21:598-614.
[9]	Oli K, Porteous J. Prevalence of rheumatic heart disease among school children in Addis Ababa. East Afr Med J. 1999; 76:601-5.
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[12]	Karmarkar MG, Venugopal V, Joshi L, and Kamboj R. Evaluation & revaluation of upper limits of normal values of anti-streptolysin O and ant-deoxyribonuclease B in Mumbai. Indian J. Med. Res. 2004; 119 (Suppl.):26-28.
[13]	Danchin, MH, Carlin JB, Devenish W, Nolan TM, and Carapetis JR. 2004. New normal ranges of antistreptolysin O and anti-deoxyribonuclease B titres for Australian children. J. Paediatr. Child Health41:583-586.
[14]	Kim S. and Lee YN. Asymptomatic infection by Streptococcus pyogenes in school children and diagnostic usefulness of antideoxyribonuclease B. J Korean Med Sci. 2005; 20:938–40.
[15]	Khaled AA and Hassan AA. Anti Streptolysin O; Normal Values for Healthy Children Aged from 5 to 15 Years Old in Sana'a City-Yemen. Annals of Clinical and Laboratory Research. 2015; Vol. 3 No. 1:1.
[16]	Steer AC, Carapetis JR, Nolan TM, Shann F. Systematic review of rheumatic heart disease prevalence in children in developing countries: the role of environmental factors. J Paediatr Child Health. 2002; 38: 229-234.
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APA Style

Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye. (2018). Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. Journal of Family Medicine and Health Care, 4(1), 1-4. https://doi.org/10.11648/j.jfmhc.20180401.11

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ACS Style

Tsegahun Asfaw; Demissew Shenkute; Mihret Tilahun; Nigus Zegeye. Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. J. Fam. Med. Health Care 2018, 4(1), 1-4. doi: 10.11648/j.jfmhc.20180401.11

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AMA Style

Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye. Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. J Fam Med Health Care. 2018;4(1):1-4. doi: 10.11648/j.jfmhc.20180401.11

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@article{10.11648/j.jfmhc.20180401.11,
  author = {Tsegahun Asfaw and Demissew Shenkute and Mihret Tilahun and Nigus Zegeye},
  title = {Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia},
  journal = {Journal of Family Medicine and Health Care},
  volume = {4},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.jfmhc.20180401.11},
  url = {https://doi.org/10.11648/j.jfmhc.20180401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20180401.11},
  abstract = {Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.},
 year = {2018}
}

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TY - JOUR
T1 - Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia
AU - Tsegahun Asfaw
AU - Demissew Shenkute
AU - Mihret Tilahun
AU - Nigus Zegeye
Y1 - 2018/04/20
PY - 2018
N1 - https://doi.org/10.11648/j.jfmhc.20180401.11
DO - 10.11648/j.jfmhc.20180401.11
T2 - Journal of Family Medicine and Health Care
JF - Journal of Family Medicine and Health Care
JO - Journal of Family Medicine and Health Care
SP - 1
EP - 4
PB - Science Publishing Group
SN - 2469-8342
UR - https://doi.org/10.11648/j.jfmhc.20180401.11
AB - Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.
VL - 4
IS - 1
ER -

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Author Information

Tsegahun Asfaw

Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia
Demissew Shenkute

Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia
Mihret Tilahun

Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia
Nigus Zegeye

Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia

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APA Style

Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye. (2018). Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. Journal of Family Medicine and Health Care, 4(1), 1-4. https://doi.org/10.11648/j.jfmhc.20180401.11

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ACS Style

Tsegahun Asfaw; Demissew Shenkute; Mihret Tilahun; Nigus Zegeye. Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. J. Fam. Med. Health Care 2018, 4(1), 1-4. doi: 10.11648/j.jfmhc.20180401.11

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AMA Style

Tsegahun Asfaw, Demissew Shenkute, Mihret Tilahun, Nigus Zegeye. Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia. J Fam Med Health Care. 2018;4(1):1-4. doi: 10.11648/j.jfmhc.20180401.11

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@article{10.11648/j.jfmhc.20180401.11,
  author = {Tsegahun Asfaw and Demissew Shenkute and Mihret Tilahun and Nigus Zegeye},
  title = {Antistreptolysin O Titers: Normal Values for Children Ages 5 to 15 at Debre Berhan Referral Hospital, Ethiopia},
  journal = {Journal of Family Medicine and Health Care},
  volume = {4},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.jfmhc.20180401.11},
  url = {https://doi.org/10.11648/j.jfmhc.20180401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfmhc.20180401.11},
  abstract = {Anti-streptolysin O (ASO) titer assists for the diagnosis of Group A, Group C and Group G streptococcal infections and their sequele. Reference value of Anti-streptolysin O titer is not available for Ethiopian populations. This study determined the upper limit of normal reference value in apparently healthy children. Participants with a history of streptococal disease were excluded. A total of 127 blood samples were collected from 127 participants with age range of 5-15 years. Serum was used to determine Anti-Streptolysin O-titers. The average ASO Upper limits of Normal (ULN) titer for the total participants was 360 IU/ml with a median 200 IU/ml. The ASO ULN for both male and female children was 320 IU/ml with a median of 200IU/ml. The highest ASO ULN was observed for the age group of 9-12 years (400 IU/ml with median of 200 IU/ml) followed by 360 IU/ml for the age group 5-8 years and age group 13-15 years with a median of 200 IU/ml. This finding shows that ASO ULN are similar to those reported in countries with different climates and populations. Package inserts interpreting ASO titer > 400 IU/ml as recent streptococcal infection is applicable for Ethiopian population.},
 year = {2018}
}

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