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Prolactin as a Marker of Active Disease in Systemic Lupus Erythematosus
Jorge Medina Castillo,
María Azucena Ramos Sánchez,
Ariana Maia Becerra Márquez
Issue:
Volume 7, Issue 4, December 2021
Pages:
73-76
Received:
29 April 2021
Accepted:
6 August 2021
Published:
19 November 2021
Abstract: Objetives. To determine the correlation between prolactin levels and disease activity classified based on the Mexican lupus erythematosus disease systemic activity index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well as manifestations of active disease were determined. Disease activity was evaluated using the Mexican Systemic Lupus Erythematosus Activity Index (MEX-SLEDAI). The correlation of MEX-SLEDAI with prolactin was determined using the Spearman correlation coefficient. The significance of differences between continuous variables was determined with the non-paired Student’s t test and the significance of differences between categorical variables was determined with Chi-square test. Results. 55 patients were included, 10 (18.1%) had MEX-SLEDAI ≥7 and 45 (81.8%) less than 7. A positive correlation was found with a Spearman rho 0.387 (p = 0.004) between the MEX-SLEDAI and the levels serum prolactin. Subjects with active disease and hyperprolactinemia had 80% manifestations at the renal level (p = 0.001). Conclusion. There is significant correlation between prolactin levels and disease activity. Hyperprolactinemia were detected in patients with renal activity as well as those with MEX-SLEDAI ≥7.
Abstract: Objetives. To determine the correlation between prolactin levels and disease activity classified based on the Mexican lupus erythematosus disease systemic activity index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well as manifestations of active disease were determined. Disease activ...
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Stroke in Sub-saharan Africa: Observations from Donka National Hospital
Vamala Guillavogui,
Djibril Sylla,
Foksouna Sakadi,
Seylan Diawara,
Nestor Onikoyamou,
Abdel-madjid Zakaria Zakaria,
Kezely Beavogui,
Amara Cisse
Issue:
Volume 7, Issue 4, December 2021
Pages:
77-80
Received:
18 March 2021
Accepted:
27 September 2021
Published:
24 November 2021
Abstract: Introduction: Stroke is a major public health problem, the consequences of which are as much medico-social as they are economic. The main objective is to make a socio-demographic, clinical, therapeutic and prognostic assessment in the short term in a medico-surgical emergency department in Guinea. Material and Methods: This was a descriptive retrospective study lasting 2 years from January 1st, 2014 to December 31st, 2015 inclusive. All complete medical records of patients hospitalized for stroke confirmed by brain scan were included in this study. Sociodemographic, clinical, para-clinical, therapeutic and evolutionary data were collected. Results: During the 2 years out of 1321 patients hospitalized in the intensive care unit, strokes represented 7.3% of cases. The average age was 67.2 years old with the extremes of 30 and 99 years old. We had a male predominance of 59 men versus 38 women with a sex ratio of 1.55. The most common cardiovascular risk factors were high blood pressure (74.23%), diabetes (22.68%), and age (89.69%). The Glasgow Score was between 3 - 8/15 in 49 patients or 50.52%. The death rate was 14.4%. Conclusion: The management of serious strokes in intensive care units in emergency rooms considerably reduces short-term mortality and neurological sequelae of patients.
Abstract: Introduction: Stroke is a major public health problem, the consequences of which are as much medico-social as they are economic. The main objective is to make a socio-demographic, clinical, therapeutic and prognostic assessment in the short term in a medico-surgical emergency department in Guinea. Material and Methods: This was a descriptive retros...
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The Problem of Early Surgical Revisions After Abdominal Surgery, Study About 83 Cases Recorded in Bangui, Central African Republic
Doui Doumgba Antoine,
Piamale Germain,
Damassara Kokonga Innocent,
Ngboko Mirotiga Pétula Anicette
Issue:
Volume 7, Issue 4, December 2021
Pages:
81-85
Received:
7 August 2021
Accepted:
23 August 2021
Published:
24 November 2021
Abstract: Objectives: To describe the characteristic of reoperated patients, the predictive factors of morbidity and mortality as well as the evolution after early reoperations. Materials and method: The study included a retrospective and prospective series. The files of patients reoperated after abdominal surgery from January 2014 to December 2019 at the general surgery department of Sino-Central African Friendship University Hospital in Bangui were analyzed. Results: Out of 1249 patients operated on and hospitalized in the surgical department and, 83 (6.6%) patients were reoperated. They were 53% male subjects. The average age was 38.4 years old. An initial intervention was carried out urgently by unqualified operators (71.1%). Postoperative peritonitis (42.2%) was the main reasons for reoperation. Time to reoperation was 8.4 days on average. The founding during reoperation was anastomotic disunity (39.8%). A bypass stoma (33.7%) associated with washing and drainage of the peritoneal cavity was performed. In 19.2% of cases, patients underwent iterative reoperation. The rate of death was 24%. Predictive factors of poor prognosis were, initial surgery for acute peritonitis, dirty surgery, patient with ASA score II and III, NISS 2 and 3, unqualified operators, iterative reoperations and digestive fistula. Conclusion: Early re-operations occurred after emergency surgery performed by an unqualified surgeon. They dependent on high mortality. To reduce rate of early reoperations and improve the prognosis, qualified surgical personnel are needed. Unqualified surgeons must be regularly retrained in essential surgical care with particular emphasis on respecting the basic principles of emergency surgery.
Abstract: Objectives: To describe the characteristic of reoperated patients, the predictive factors of morbidity and mortality as well as the evolution after early reoperations. Materials and method: The study included a retrospective and prospective series. The files of patients reoperated after abdominal surgery from January 2014 to December 2019 at the ge...
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Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia
Beksisa Urge,
Tamirat Seyoum,
Temesgen Kassa,
Markos Tadele,
Fekadu Gutema,
Neima Arebu,
Ulfina Galmessa,
Million Tadese
Issue:
Volume 7, Issue 4, December 2021
Pages:
86-90
Received:
20 October 2021
Accepted:
24 November 2021
Published:
24 November 2021
Abstract: Gastrointestinal parasites are economically important in the dairy industry. A study was carried out to evaluate the therapeutic efficacy of anthelmintic drugs (Tetraclozan 3400 mg and Albendazole 2500mg) for the treatment of GIT worms in cross-bred cows at Holeta research center. A total of sixty crossbred cows were purposively screened and divided into three groups for the current study. The first groups served as untreated control, the second and third groups were treated with Albendazole and Tetraclozan drugs respectively. Moreover, fecal samples were collected before and after treatment to count the eggs per gram (EPG) of feces and to evaluate drug efficacy percentage. Efficacy for each anthelmintic was determined by the Fecal Egg Count Reduction Test (FECRT). The mean EPG count before and after treatment with Tetraclozan drug on 0. 14th and 21st days was 520±102.1, 100±54.6 and 15±6.7 respectively whereas the mean EPG count on 0, 14th and 21st days before and after treatment with Albendazole drug was 450±127.2, 150±46.2 and 20±6.8 respectively. The overall percentage efficacy of Tetraclozan and Albendazole drugs were 97.11 and 95.5 percent respectively. The study indicated that the two anthelmintic drugs were efficacious against worm infection and thus, leads to reduction in EPG count. It is important to explore the detailed pharmacokinetic and toxic effects of these drugs for wide therapeutic uses in animals. It is also recommended that the clinical responses of GIT helminthes to prophylactic and therapeutic drugs need to be periodically monitored in the farms and further introduced to smallholder farmers.
Abstract: Gastrointestinal parasites are economically important in the dairy industry. A study was carried out to evaluate the therapeutic efficacy of anthelmintic drugs (Tetraclozan 3400 mg and Albendazole 2500mg) for the treatment of GIT worms in cross-bred cows at Holeta research center. A total of sixty crossbred cows were purposively screened and divide...
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Subtle Activities of Specific Plain Subtalar Joint May Account for Non-injured Ankle Pain: A Case Report
Issue:
Volume 7, Issue 4, December 2021
Pages:
91-95
Received:
14 November 2021
Accepted:
1 December 2021
Published:
9 December 2021
Abstract: Current clinical practice focuses on discovering injuries and then formulating treatment plans. But some injuries have nothing to do with symptoms, including pain, let alone those situations where there is no injury. The ankle, especially the subtalar joint, has a high rate of variation, so the subtle activities of subtalar joint are exactly important in patients who have biomechanical issues, especially in the condition that all check-ups are normal. This paper presented a case report of a 16-year-old teenager who was a professional basketball player in local senior high school. The pain appeared in both of his soles and ankles as long as he played basketball and disappeared immediately after the exercise since his childhood. All the routine tests involving MRI and ultrasound were normal. No impingement condition was found. 3D dynamic reconstruction combined with 3D continuum model was performed. The specific plain subtalar articular surfaces were revealed. The treatment involving dynamic fixation via rigid tape and training lasted for 4 weeks. Before the treatment, the right talus was more stable than the left one (Δ(norm)=0.5126), and the calcaneus was the other way around (Δ(norm)=0.6280). The differences of degrees of freedom between two sides decreased significantly (Δ(norm)=0.0833, 0.000) after treatment. Besides, the steep and tone of both sides of talus and calcaneus revealed relative rotation and translation which indicated that the movement of subtalar joint trended to the balance of stability and mobility. This patient improved his athletic ability and got pain free immediately after the first treatment. Moreover, the pain didn’t appear during the 12-month follow-up. Therefore, we conclude that based on our treatment which focused on the reduction of the subtle activities of subtalar joint, we support that the subtle activities of variable subtalar joint may influence the athletic abilities and cause some symptoms. Therefore, the importance of bone shape which is the chief culprit of abnormal mobility shall be taken seriously. Moreover, in the case calculation based on the mathematical model, stable calcaneus and flexible talus make the better balance of stability and mobility and are necessary for available exercises.
Abstract: Current clinical practice focuses on discovering injuries and then formulating treatment plans. But some injuries have nothing to do with symptoms, including pain, let alone those situations where there is no injury. The ankle, especially the subtalar joint, has a high rate of variation, so the subtle activities of subtalar joint are exactly import...
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