Research Article
Research into Predictive Factors for the Success or Failure of Radioiodine Therapy in the Treatment of Hyperthyroidism in Senegal
Issue:
Volume 14, Issue 1, June 2026
Pages:
1-7
Received:
1 December 2025
Accepted:
23 December 2025
Published:
16 January 2026
Abstract: Radioiodine therapy, a treatment method for hyperthyroidism, has been practiced in Senegal since 2016. The objective of our study was to identify predictive factors for the success or failure of radioiodine therapy in the management of hyperthyroidism in Senegal. A retrospective study was initiated in the nuclear medicine department of the Idrissa Pouye Hospital in Grand Yoff. It included the medical records of 172 patients followed for hyperthyroidism and treated with iodine-131. Demographic, clinical, paraclinical, and therapeutic aspects, as well as the evaluation of thyroid function at 3 and 6 months post-radioiodine therapy, were studied. The therapeutic efficacy at 3 months was 44.1%. Among the 17 patients who failed treatment, 12 were under 50 years of age. No statistically significant relationship was found between treatment failure and age (p = 0.877. However, the difference was statistically significant between men and women in terms of treatment failure (p=0.043). Vascular goiter, etiology, initial antithyroid drug use, and a short interval between antithyroid drugs (ATDs) discontinuation were factors contributing to treatment failure. A strong correlation existed between therapeutic efficacy and the administered dose (p=0.000). The 6-month success rate was 62.4%. The final therapeutic efficacy was 73.75%. Radioiodine therapy is an effective treatment for hyperthyroidism, achieving a high remission rate.
Abstract: Radioiodine therapy, a treatment method for hyperthyroidism, has been practiced in Senegal since 2016. The objective of our study was to identify predictive factors for the success or failure of radioiodine therapy in the management of hyperthyroidism in Senegal. A retrospective study was initiated in the nuclear medicine department of the Idrissa ...
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Research Article
Assessment of Pediatric Exposure to Ionizing Radiation in Diagnostic Radiography: A Study at Diamniadio Children’s Hospital
Issue:
Volume 14, Issue 1, June 2026
Pages:
8-13
Received:
9 January 2026
Accepted:
27 January 2026
Published:
9 February 2026
Abstract: Radiography, widely used for diagnostic purposes, represents a major source of exposure to ionizing radiation in children, a population particularly sensitive to the biological effects of radiation. Despite its widespread use, no study has previously assessed pediatric exposure to ionizing radiation in Senegal. This study was therefore conducted to measure and analyze exposure levels during routine radiographic examinations at the Diamniadio Children’s Hospital. A retrospective descriptive and analytical study was carried out from January 1 to June 30, 2022, within the radiology and medical biology departments. Demographic data and anatomical regions examined were collected from radiology registers. Data were entered using Microsoft Excel 2016 and analyzed with RStudio version 4.1.2. A total of 2820 children were included, with a median age of 4.35 years and a male-to-female ratio of 1.58. The [0-5 years [and [5-10 years [age groups were the most represented, accounting for 53.2% and 30.5% of cases, respectively. Chest and lower limb radiographs were the most frequently performed examinations across all age groups, with a higher exposure frequency observed in boys. These findings indicate that children undergo a substantial number of radiographic examinations, which may increase stochastic radiation effects. Therefore, strict application of radiological protection principles by radiologists and referring physicians is essential.
Abstract: Radiography, widely used for diagnostic purposes, represents a major source of exposure to ionizing radiation in children, a population particularly sensitive to the biological effects of radiation. Despite its widespread use, no study has previously assessed pediatric exposure to ionizing radiation in Senegal. This study was therefore conducted to...
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Research Article
Physicochemical Development and Characterization of a Hydroxyapatite-Biocompatible Polymer Matrix for Controlled Insulin Release
Issue:
Volume 14, Issue 1, June 2026
Pages:
14-23
Received:
9 February 2026
Accepted:
21 February 2026
Published:
10 March 2026
DOI:
10.11648/j.ejb.20261401.13
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Abstract: This study investigates the controlled release of insulin from composite matrices based on hydroxyapatite and Eudragit® polymers, with the aim of developing an efficient and tunable oral or implantable insulin delivery system. Hydroxyapatite was synthesized by chemical precipitation method with a Ca/P molar ratio of 1.66, closely mimicking the stoichiometry of biological apatite, and subsequently thermally treated at 800°C to enhance its crystallinity, mechanical strength, and structural stability. Two distinct matrix formulations were developed using Eudragit® RSPM and Eudragit® RS100, two pH-independent, water-insoluble polymers known for their controlled permeability properties, and were thoroughly characterized in terms of their technological and pharmacotechnical properties. Evaluation demonstrated good matrix cohesion, adequate hardness, and full compliance with mass uniformity requirements according to pharmacopoeial standards. In vitro release studies conducted under physiologically relevant conditions revealed clearly differentiated kinetic profiles depending on both the formulation type and the insulin loading dose. The first batch exhibited a classical first-order release kinetics, achieving complete insulin release over an extended period of seven days, suggesting a diffusion-controlled mechanism. In contrast, the second batch displayed a sigmoidal release profile accurately described by the Boltzmann equation (r² = 0.99), characterized by a marked acceleration phase beginning on the third day, indicative of a more complex release mechanism. These findings demonstrate that insulin loading significantly influences the release mechanism and overall kinetics, highlighting the strong potential of hydroxyapatite-polymer composite matrices for the rational design of advanced controlled insulin delivery systems.
Abstract: This study investigates the controlled release of insulin from composite matrices based on hydroxyapatite and Eudragit® polymers, with the aim of developing an efficient and tunable oral or implantable insulin delivery system. Hydroxyapatite was synthesized by chemical precipitation method with a Ca/P molar ratio of 1.66, closely mimicking the stoi...
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,
Woury Sow
