A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery

Omer Ibrahim Abdallh Omer

doi:doi:10.11648/j.pst.20210502.16

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A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery

Omer Ibrahim Abdallh Omer

Published in Pharmaceutical Science and Technology (Volume 5, Issue 2)

Received: 16 October 2021 Accepted: 15 November 2021 Published: 29 November 2021

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Abstract

Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. Zebra fish has been used as a preclinical model for identifications of various natural compounds presents on natural products, early life stage tests with zebra fish used to detect toxicity of compounds from natural bloom extract on their embryolarval development. The use of Medicinal plants for treatment of neurological & neuro-degenerative disorders, cardiovascular and anti-melongenesis are very common. Bitter gourd shows anti-diabetic effects by using zebra fish model in a designed experiment. Zebra fish has been used as a tool for discovering of phyto-chemical compounds in natural products and their activities such as, fruit of Terminalia chebula possessing the activity of anti- epileptic, Oxygonum sinuatum and Plectranthus barbatus showed anti-angogensis with the active compounds Emodin & Coleon A lactone. Cardiac toxicity by the fruit extract of M. charantia reported. Zebra fish is gaining more interest as a preclinical tool for drug discovery because it has been demonstrate that pharmacokinetic analysis can be under-taken in this model. The study concludes that and gives a desktop reference to the new researchers in finding out the earlier attempts which were made on zebra fish (Danio rerio) as a preclinical tool in natural product discovery.

Published in	Pharmaceutical Science and Technology (Volume 5, Issue 2)
DOI	10.11648/j.pst.20210502.16
Page(s)	62-67
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Zebra Fish, Natural Products, Diabetes Mellitus (DM), Hypertension, Neurological Disorders, Bitter Gourd

References

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[2]	N. Tabassum, H. Tai, D. W. Jung, and D. R. Williams, “Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products,” Evidence-based Complement. Altern. Med., vol. 2015, 2015, doi: 10.1155/2015/287847.
[3]	A. D. Crawford et al., “Zebrafish bioassay-guided natural product discovery: Isolation of angiogenesis inhibitors from East African medicinal plants,” PLoS One, vol. 6, no. 2, pp. 1–9, 2011, doi: 10.1371/journal.pone.0014694.
[4]	M. Ghorbani, “Iranian traditional medicine for treatment of type II diabetes, anxiety and hypertension with introduction of zebrafish model system for their screening,” Int. J. Herb. Med., vol. 2, no. 5, pp. 13–19, 2014.
[5]	M. C. Cheng et al., “Melanogenesis inhibitors from the rhizoma of ligusticum sinense in B16-f10 melanoma cells in vitro and zebrafish in vivo,” Int. J. Mol. Sci., vol. 19, no. 12, pp. 1–17, 2018, doi: 10.3390/ijms19123994.
[6]	A. Pitchai, R. K. Rajaretinam, and J. L. Freeman, “Zebrafish as an Emerging Model for Bioassay-Guided Natural Product Drug Discovery for Neurological Disorders,” Medicines, vol. 6, no. 2, p. 61, 2019, doi: 10.3390/medicines6020061.
[7]	Y. Li et al., “Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier,” Pharmacol. Res., vol. 125, pp. 246–257, 2017, doi: 10.1016/j.phrs.2017.08.017.
[8]	M. F. Khan, N. Abutaha, F. A. Nasr, A. S. Alqahtani, O. M. Noman, and M. A. M. Wadaan, “Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos,” BMC Complement. Altern. Med., vol. 19, no. 1, p. 184, 2019, doi: 10.1186/s12906-019-2599-0.
[9]	K. Benchoula et al., “Optimization of hyperglycemic induction in zebrafish and evaluation of its blood glucose level and metabolite fingerprint treated with psychotria malayana Jack Leaf extract,” Molecules, vol. 24, no. 8, 2019, doi: 10.3390/molecules24081506.
[10]	X. Wang et al., “Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library,” DMM Dis. Model. Mech., vol. 7, no. 1, pp. 163–169, 2014, doi: 10.1242/dmm.012047.
[11]	K. Chen et al., “Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity,” Exp. Ther. Med., vol. 16, no. 6, pp. 4562–4568, 2018, doi: 10.3892/etm.2018.6748.
[12]	P. Deshpande, N. Gogia, and A. Singh, “Exploring the efficacy of natural products in alleviating Alzheimer’s disease,” Neural Regen. Res., vol. 14, no. 8, pp. 1321–1329, 2019, doi: 10.4103/1673-5374.253509.
[13]	I. El Ghazali et al., “Compensatory growth induced in zebrafish larvae after pre-exposure to a microcystis aeruginosa natural bloom extract containing microcystins,” Int. J. Mol. Sci., vol. 10, no. 1, pp. 133–146, 2009, doi: 10.3390/ijms10010133.
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APA Style

Omer Ibrahim Abdallh Omer. (2021). A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery. Pharmaceutical Science and Technology, 5(2), 62-67. https://doi.org/10.11648/j.pst.20210502.16

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ACS Style

Omer Ibrahim Abdallh Omer. A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery. Pharm. Sci. Technol. 2021, 5(2), 62-67. doi: 10.11648/j.pst.20210502.16

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AMA Style

Omer Ibrahim Abdallh Omer. A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery. Pharm Sci Technol. 2021;5(2):62-67. doi: 10.11648/j.pst.20210502.16

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@article{10.11648/j.pst.20210502.16,
  author = {Omer Ibrahim Abdallh Omer},
  title = {A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery},
  journal = {Pharmaceutical Science and Technology},
  volume = {5},
  number = {2},
  pages = {62-67},
  doi = {10.11648/j.pst.20210502.16},
  url = {https://doi.org/10.11648/j.pst.20210502.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20210502.16},
  abstract = {Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. Zebra fish has been used as a preclinical model for identifications of various natural compounds presents on natural products, early life stage tests with zebra fish used to detect toxicity of compounds from natural bloom extract on their embryolarval development. The use of Medicinal plants for treatment of neurological & neuro-degenerative disorders, cardiovascular and anti-melongenesis are very common. Bitter gourd shows anti-diabetic effects by using zebra fish model in a designed experiment. Zebra fish has been used as a tool for discovering of phyto-chemical compounds in natural products and their activities such as, fruit of Terminalia chebula possessing the activity of anti- epileptic, Oxygonum sinuatum and Plectranthus barbatus showed anti-angogensis with the active compounds Emodin & Coleon A lactone. Cardiac toxicity by the fruit extract of M. charantia reported. Zebra fish is gaining more interest as a preclinical tool for drug discovery because it has been demonstrate that pharmacokinetic analysis can be under-taken in this model. The study concludes that and gives a desktop reference to the new researchers in finding out the earlier attempts which were made on zebra fish (Danio rerio) as a preclinical tool in natural product discovery.},
 year = {2021}
}

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TY  - JOUR
T1  - A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery
AU  - Omer Ibrahim Abdallh Omer
Y1  - 2021/11/29
PY  - 2021
N1  - https://doi.org/10.11648/j.pst.20210502.16
DO  - 10.11648/j.pst.20210502.16
T2  - Pharmaceutical Science and Technology
JF  - Pharmaceutical Science and Technology
JO  - Pharmaceutical Science and Technology
SP  - 62
EP  - 67
PB  - Science Publishing Group
SN  - 2640-4540
UR  - https://doi.org/10.11648/j.pst.20210502.16
AB  - Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. Zebra fish has been used as a preclinical model for identifications of various natural compounds presents on natural products, early life stage tests with zebra fish used to detect toxicity of compounds from natural bloom extract on their embryolarval development. The use of Medicinal plants for treatment of neurological & neuro-degenerative disorders, cardiovascular and anti-melongenesis are very common. Bitter gourd shows anti-diabetic effects by using zebra fish model in a designed experiment. Zebra fish has been used as a tool for discovering of phyto-chemical compounds in natural products and their activities such as, fruit of Terminalia chebula possessing the activity of anti- epileptic, Oxygonum sinuatum and Plectranthus barbatus showed anti-angogensis with the active compounds Emodin & Coleon A lactone. Cardiac toxicity by the fruit extract of M. charantia reported. Zebra fish is gaining more interest as a preclinical tool for drug discovery because it has been demonstrate that pharmacokinetic analysis can be under-taken in this model. The study concludes that and gives a desktop reference to the new researchers in finding out the earlier attempts which were made on zebra fish (Danio rerio) as a preclinical tool in natural product discovery.
VL  - 5
IS  - 2
ER  -

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Author Information

Omer Ibrahim Abdallh Omer

Department of Pharmacy Practice, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India

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APA Style

Omer Ibrahim Abdallh Omer. (2021). A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery. Pharmaceutical Science and Technology, 5(2), 62-67. https://doi.org/10.11648/j.pst.20210502.16

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ACS Style

Omer Ibrahim Abdallh Omer. A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery. Pharm. Sci. Technol. 2021, 5(2), 62-67. doi: 10.11648/j.pst.20210502.16

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AMA Style

Omer Ibrahim Abdallh Omer. A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery. Pharm Sci Technol. 2021;5(2):62-67. doi: 10.11648/j.pst.20210502.16

Copy | Download

@article{10.11648/j.pst.20210502.16,
  author = {Omer Ibrahim Abdallh Omer},
  title = {A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery},
  journal = {Pharmaceutical Science and Technology},
  volume = {5},
  number = {2},
  pages = {62-67},
  doi = {10.11648/j.pst.20210502.16},
  url = {https://doi.org/10.11648/j.pst.20210502.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20210502.16},
  abstract = {Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. Zebra fish has been used as a preclinical model for identifications of various natural compounds presents on natural products, early life stage tests with zebra fish used to detect toxicity of compounds from natural bloom extract on their embryolarval development. The use of Medicinal plants for treatment of neurological & neuro-degenerative disorders, cardiovascular and anti-melongenesis are very common. Bitter gourd shows anti-diabetic effects by using zebra fish model in a designed experiment. Zebra fish has been used as a tool for discovering of phyto-chemical compounds in natural products and their activities such as, fruit of Terminalia chebula possessing the activity of anti- epileptic, Oxygonum sinuatum and Plectranthus barbatus showed anti-angogensis with the active compounds Emodin & Coleon A lactone. Cardiac toxicity by the fruit extract of M. charantia reported. Zebra fish is gaining more interest as a preclinical tool for drug discovery because it has been demonstrate that pharmacokinetic analysis can be under-taken in this model. The study concludes that and gives a desktop reference to the new researchers in finding out the earlier attempts which were made on zebra fish (Danio rerio) as a preclinical tool in natural product discovery.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - A Review on Zebra Fish as a Preclinical Model for Natural Drug Discovery
AU  - Omer Ibrahim Abdallh Omer
Y1  - 2021/11/29
PY  - 2021
N1  - https://doi.org/10.11648/j.pst.20210502.16
DO  - 10.11648/j.pst.20210502.16
T2  - Pharmaceutical Science and Technology
JF  - Pharmaceutical Science and Technology
JO  - Pharmaceutical Science and Technology
SP  - 62
EP  - 67
PB  - Science Publishing Group
SN  - 2640-4540
UR  - https://doi.org/10.11648/j.pst.20210502.16
AB  - Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. Zebra fish has been used as a preclinical model for identifications of various natural compounds presents on natural products, early life stage tests with zebra fish used to detect toxicity of compounds from natural bloom extract on their embryolarval development. The use of Medicinal plants for treatment of neurological & neuro-degenerative disorders, cardiovascular and anti-melongenesis are very common. Bitter gourd shows anti-diabetic effects by using zebra fish model in a designed experiment. Zebra fish has been used as a tool for discovering of phyto-chemical compounds in natural products and their activities such as, fruit of Terminalia chebula possessing the activity of anti- epileptic, Oxygonum sinuatum and Plectranthus barbatus showed anti-angogensis with the active compounds Emodin & Coleon A lactone. Cardiac toxicity by the fruit extract of M. charantia reported. Zebra fish is gaining more interest as a preclinical tool for drug discovery because it has been demonstrate that pharmacokinetic analysis can be under-taken in this model. The study concludes that and gives a desktop reference to the new researchers in finding out the earlier attempts which were made on zebra fish (Danio rerio) as a preclinical tool in natural product discovery.
VL  - 5
IS  - 2
ER  -

Copy | Download