Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy

Huiping Liang; Tingting Lu; Huaying Liu; Lili Tan; Li Li; Xiaojun Tang

doi:doi:10.11648/j.plm.20190301.12

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Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy

Huiping Liang, Tingting Lu, Huaying Liu, Lili Tan, Li Li, Xiaojun Tang

Published in Pathology and Laboratory Medicine (Volume 3, Issue 1)

Received: 5 November 2018 Accepted: 14 December 2018 Published: 21 January 2019

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Abstract

Background: Although there are many biochemical indicators to reflect changes in renal function, but these indicators can not reflect renal damage timely and accurately. Renal microcirculation changes can not be reflected also. This study amied at evaluate significance of renal perfusion angiography and the indexes of relevant biochemical in early diagnosis of type 2 diabetic nephropathy. Methods: 30 I-III T2DN patients (DN group) and 25 healthy volunteers (control group) were studied, and both of groups were performed renal perfusion CT angiography imaging examination. Biochemical indexes, which are fasting blood glucose (FBG), urinary albumin excretion rate (UAE), 24 h urine protein quantitation (UPQ), blood urea nitrogen (BUN), serum creatinine (Scr), Cystatin C(Cys C), random albumin to creatinine ratio(ACR), were measured in both of groups, then simplified MDRD (Modification of Diet in Renal Disease) and Cys C equation were used to calculate the Estimated Glomerular Filtration Rate(eGFR). double-renal perfusion contrast scanning in both of groups were also conducted to obtain data of double renal blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) for statistical analysis. Results: The indexes of BF, MTT and FBG, UAE, 24 h UPQ, ACR, Cys C, eGFR were found to have relative strong correlation and statistical significance (P<0.05). BF was shown the negative correlation with those indexes, however MTT had positive correlation with them. The area under ROC (receiver operating characteristic curve), were more than 0.9 for UAE, ACR, NF, and MTT, and it indicate that these indexes have relatively positive effect on the early diagnosis of the DN. For 24 h UPQ, cysteine C, eGFR and BV value, the area Under the curve are between 0.7 and 0.9, which indicates that diagnosis using those index for the disease were accuracy. Thus, the above indexes have better diagnostic efficiency compared to Scr, BUN and eGFR. Conclusion: The biochemical indexes such as UAE, ACR and renal perfusion indexes such as BF and MTT can be applied in the early predicative diagnosis and DN screening. Its diagnosis effect is better than other biochemical indexes.

Published in	Pathology and Laboratory Medicine (Volume 3, Issue 1)
DOI	10.11648/j.plm.20190301.12
Page(s)	5-9
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Type 2 Diabetes Mellitus, Diabetic Nephropathies, Renal Function, Tomography, Spiral Computed, Perfusion

References

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[2]	Association AD: Standards of medical care in diabetes—2012. Diabetes Care 2012;35:S11-S63.
[3]	Z S, P Z, C Z: Prevalence of chronic kidney disease in china. Lancet 2012;379:815-822.
[4]	Philips JC, Marchand M, Scheen AJ: Pulse pressure and cardiovascular autonomic neuropathy according to duration of type 1 diabetes. Diabetes/metabolism Research & Reviews 2009;25:442-451.
[5]	National eGFR project collaboration group of China: Modification and evaluation of mdrd estimating equation for chinese patients with chronic kidney disease. Chinese Journal of Nephrology 2006;22:589-595.
[6]	Feng J, Qiu L, Zhang L, Li X, Yang Y, Zeng P, Guo X, Qin Y, Liu H, Han X: Multicenter study of creatinine- and/or cystatin c-based equations for estimation of glomerular filtration rates in chinese patients with chronic kidney disease. Plos One 2013;8:e57240.
[7]	Bembde AS: A study of plasma fibrinogen level in type-2 diabetes mellitus and its relation to glycemic control. Indian Journal of Hematology and Blood Transfusion 2012; 28: 105-108.
[8]	Carville S, Wonderling D, Stevens P: Early identification and management of chronic kidney disease in adults: Summary of updated nice guidance. Bmj 2014;349:g4507.
[9]	Macisaac RJ, Premaratne E, Jerums G: Estimating glomerular filtration rate in diabetes using serum cystatin c. Clinical Biochemist Reviews 2011;32:61-67.
[10]	Assal HS, Tawfeek S, Rasheed EA, Ellebedy D, Thabet EH: Serum cystatin c and tubular urinary enzymes as biomarkers of renal dysfunction in type 2 diabetes mellitus. Clinical Medicine Insights Endocrinology & Diabetes 2013;6:7.
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[13]	Dawson P: Functional imaging in ct. European Journal of Radiology 2006;60:331-340.
[14]	Murakami R, Hayashi H, Sugizaki K, Yoshida T, Okazaki E, Kumita S, Owan C: Contrast-induced nephropathy in patients with renal insufficiency undergoing contrast-enhanced mdct. European Radiology 2012;22:2147-2152.

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APA Style

Huiping Liang, Tingting Lu, Huaying Liu, Lili Tan, Li Li, et al. (2019). Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy. Pathology and Laboratory Medicine, 3(1), 5-9. https://doi.org/10.11648/j.plm.20190301.12

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ACS Style

Huiping Liang; Tingting Lu; Huaying Liu; Lili Tan; Li Li, et al. Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy. Pathol. Lab. Med. 2019, 3(1), 5-9. doi: 10.11648/j.plm.20190301.12

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AMA Style

Huiping Liang, Tingting Lu, Huaying Liu, Lili Tan, Li Li, et al. Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy. Pathol Lab Med. 2019;3(1):5-9. doi: 10.11648/j.plm.20190301.12

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@article{10.11648/j.plm.20190301.12,
  author = {Huiping Liang and Tingting Lu and Huaying Liu and Lili Tan and Li Li and Xiaojun Tang},
  title = {Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy},
  journal = {Pathology and Laboratory Medicine},
  volume = {3},
  number = {1},
  pages = {5-9},
  doi = {10.11648/j.plm.20190301.12},
  url = {https://doi.org/10.11648/j.plm.20190301.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20190301.12},
  abstract = {Background: Although there are many biochemical indicators to reflect changes in renal function, but these indicators can not reflect renal damage timely and accurately. Renal microcirculation changes can not be reflected also. This study amied at evaluate significance of renal perfusion angiography and the indexes of relevant biochemical in early diagnosis of type 2 diabetic nephropathy. Methods: 30 I-III T2DN patients (DN group) and 25 healthy volunteers (control group) were studied, and both of groups were performed renal perfusion CT angiography imaging examination. Biochemical indexes, which are fasting blood glucose (FBG), urinary albumin excretion rate (UAE), 24 h urine protein quantitation (UPQ), blood urea nitrogen (BUN), serum creatinine (Scr), Cystatin C(Cys C), random albumin to creatinine ratio(ACR), were measured in both of groups, then simplified MDRD (Modification of Diet in Renal Disease) and Cys C equation were used to calculate the Estimated Glomerular Filtration Rate(eGFR). double-renal perfusion contrast scanning in both of groups were also conducted to obtain data of double renal blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) for statistical analysis. Results: The indexes of BF, MTT and FBG, UAE, 24 h UPQ, ACR, Cys C, eGFR were found to have relative strong correlation and statistical significance (P<0.05). BF was shown the negative correlation with those indexes, however MTT had positive correlation with them. The area under ROC (receiver operating characteristic curve), were more than 0.9 for UAE, ACR, NF, and MTT, and it indicate that these indexes have relatively positive effect on the early diagnosis of the DN. For 24 h UPQ, cysteine C, eGFR and BV value, the area Under the curve are between 0.7 and 0.9, which indicates that diagnosis using those index for the disease were accuracy. Thus, the above indexes have better diagnostic efficiency compared to Scr, BUN and eGFR. Conclusion: The biochemical indexes such as UAE, ACR and renal perfusion indexes such as BF and MTT can be applied in the early predicative diagnosis and DN screening. Its diagnosis effect is better than other biochemical indexes.},
 year = {2019}
}

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TY  - JOUR
T1  - Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy
AU  - Huiping Liang
AU  - Tingting Lu
AU  - Huaying Liu
AU  - Lili Tan
AU  - Li Li
AU  - Xiaojun Tang
Y1  - 2019/01/21
PY  - 2019
N1  - https://doi.org/10.11648/j.plm.20190301.12
DO  - 10.11648/j.plm.20190301.12
T2  - Pathology and Laboratory Medicine
JF  - Pathology and Laboratory Medicine
JO  - Pathology and Laboratory Medicine
SP  - 5
EP  - 9
PB  - Science Publishing Group
SN  - 2640-4478
UR  - https://doi.org/10.11648/j.plm.20190301.12
AB  - Background: Although there are many biochemical indicators to reflect changes in renal function, but these indicators can not reflect renal damage timely and accurately. Renal microcirculation changes can not be reflected also. This study amied at evaluate significance of renal perfusion angiography and the indexes of relevant biochemical in early diagnosis of type 2 diabetic nephropathy. Methods: 30 I-III T2DN patients (DN group) and 25 healthy volunteers (control group) were studied, and both of groups were performed renal perfusion CT angiography imaging examination. Biochemical indexes, which are fasting blood glucose (FBG), urinary albumin excretion rate (UAE), 24 h urine protein quantitation (UPQ), blood urea nitrogen (BUN), serum creatinine (Scr), Cystatin C(Cys C), random albumin to creatinine ratio(ACR), were measured in both of groups, then simplified MDRD (Modification of Diet in Renal Disease) and Cys C equation were used to calculate the Estimated Glomerular Filtration Rate(eGFR). double-renal perfusion contrast scanning in both of groups were also conducted to obtain data of double renal blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) for statistical analysis. Results: The indexes of BF, MTT and FBG, UAE, 24 h UPQ, ACR, Cys C, eGFR were found to have relative strong correlation and statistical significance (P<0.05). BF was shown the negative correlation with those indexes, however MTT had positive correlation with them. The area under ROC (receiver operating characteristic curve), were more than 0.9 for UAE, ACR, NF, and MTT, and it indicate that these indexes have relatively positive effect on the early diagnosis of the DN. For 24 h UPQ, cysteine C, eGFR and BV value, the area Under the curve are between 0.7 and 0.9, which indicates that diagnosis using those index for the disease were accuracy. Thus, the above indexes have better diagnostic efficiency compared to Scr, BUN and eGFR. Conclusion: The biochemical indexes such as UAE, ACR and renal perfusion indexes such as BF and MTT can be applied in the early predicative diagnosis and DN screening. Its diagnosis effect is better than other biochemical indexes.
VL  - 3
IS  - 1
ER  -

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Author Information

Huiping Liang

Department of Medicine, Guangxi Medical College, Nanning, PR China
Tingting Lu

Department of Medical Technology, Guangxi Medical College, Nanning, PR China
Huaying Liu

Department of Medicine, Guangxi Medical College, Nanning, PR China
Lili Tan

Department of Medical Technology, Guangxi Medical College, Nanning, PR China
Li Li

Department of Medicine, Guangxi Medical College, Nanning, PR China
Xiaojun Tang

Department of Medical Technology, Guangxi Medical College, Nanning, PR China

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Plain Text BibTeX RIS

APA Style

Huiping Liang, Tingting Lu, Huaying Liu, Lili Tan, Li Li, et al. (2019). Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy. Pathology and Laboratory Medicine, 3(1), 5-9. https://doi.org/10.11648/j.plm.20190301.12

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ACS Style

Huiping Liang; Tingting Lu; Huaying Liu; Lili Tan; Li Li, et al. Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy. Pathol. Lab. Med. 2019, 3(1), 5-9. doi: 10.11648/j.plm.20190301.12

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AMA Style

Huiping Liang, Tingting Lu, Huaying Liu, Lili Tan, Li Li, et al. Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy. Pathol Lab Med. 2019;3(1):5-9. doi: 10.11648/j.plm.20190301.12

Copy | Download

@article{10.11648/j.plm.20190301.12,
  author = {Huiping Liang and Tingting Lu and Huaying Liu and Lili Tan and Li Li and Xiaojun Tang},
  title = {Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy},
  journal = {Pathology and Laboratory Medicine},
  volume = {3},
  number = {1},
  pages = {5-9},
  doi = {10.11648/j.plm.20190301.12},
  url = {https://doi.org/10.11648/j.plm.20190301.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.plm.20190301.12},
  abstract = {Background: Although there are many biochemical indicators to reflect changes in renal function, but these indicators can not reflect renal damage timely and accurately. Renal microcirculation changes can not be reflected also. This study amied at evaluate significance of renal perfusion angiography and the indexes of relevant biochemical in early diagnosis of type 2 diabetic nephropathy. Methods: 30 I-III T2DN patients (DN group) and 25 healthy volunteers (control group) were studied, and both of groups were performed renal perfusion CT angiography imaging examination. Biochemical indexes, which are fasting blood glucose (FBG), urinary albumin excretion rate (UAE), 24 h urine protein quantitation (UPQ), blood urea nitrogen (BUN), serum creatinine (Scr), Cystatin C(Cys C), random albumin to creatinine ratio(ACR), were measured in both of groups, then simplified MDRD (Modification of Diet in Renal Disease) and Cys C equation were used to calculate the Estimated Glomerular Filtration Rate(eGFR). double-renal perfusion contrast scanning in both of groups were also conducted to obtain data of double renal blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) for statistical analysis. Results: The indexes of BF, MTT and FBG, UAE, 24 h UPQ, ACR, Cys C, eGFR were found to have relative strong correlation and statistical significance (P<0.05). BF was shown the negative correlation with those indexes, however MTT had positive correlation with them. The area under ROC (receiver operating characteristic curve), were more than 0.9 for UAE, ACR, NF, and MTT, and it indicate that these indexes have relatively positive effect on the early diagnosis of the DN. For 24 h UPQ, cysteine C, eGFR and BV value, the area Under the curve are between 0.7 and 0.9, which indicates that diagnosis using those index for the disease were accuracy. Thus, the above indexes have better diagnostic efficiency compared to Scr, BUN and eGFR. Conclusion: The biochemical indexes such as UAE, ACR and renal perfusion indexes such as BF and MTT can be applied in the early predicative diagnosis and DN screening. Its diagnosis effect is better than other biochemical indexes.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Significance of Renal Perfusion Angiography and Biochemical Indicators in Early Diagnosis of Type 2 Diabetic Nephropathy
AU  - Huiping Liang
AU  - Tingting Lu
AU  - Huaying Liu
AU  - Lili Tan
AU  - Li Li
AU  - Xiaojun Tang
Y1  - 2019/01/21
PY  - 2019
N1  - https://doi.org/10.11648/j.plm.20190301.12
DO  - 10.11648/j.plm.20190301.12
T2  - Pathology and Laboratory Medicine
JF  - Pathology and Laboratory Medicine
JO  - Pathology and Laboratory Medicine
SP  - 5
EP  - 9
PB  - Science Publishing Group
SN  - 2640-4478
UR  - https://doi.org/10.11648/j.plm.20190301.12
AB  - Background: Although there are many biochemical indicators to reflect changes in renal function, but these indicators can not reflect renal damage timely and accurately. Renal microcirculation changes can not be reflected also. This study amied at evaluate significance of renal perfusion angiography and the indexes of relevant biochemical in early diagnosis of type 2 diabetic nephropathy. Methods: 30 I-III T2DN patients (DN group) and 25 healthy volunteers (control group) were studied, and both of groups were performed renal perfusion CT angiography imaging examination. Biochemical indexes, which are fasting blood glucose (FBG), urinary albumin excretion rate (UAE), 24 h urine protein quantitation (UPQ), blood urea nitrogen (BUN), serum creatinine (Scr), Cystatin C(Cys C), random albumin to creatinine ratio(ACR), were measured in both of groups, then simplified MDRD (Modification of Diet in Renal Disease) and Cys C equation were used to calculate the Estimated Glomerular Filtration Rate(eGFR). double-renal perfusion contrast scanning in both of groups were also conducted to obtain data of double renal blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) for statistical analysis. Results: The indexes of BF, MTT and FBG, UAE, 24 h UPQ, ACR, Cys C, eGFR were found to have relative strong correlation and statistical significance (P<0.05). BF was shown the negative correlation with those indexes, however MTT had positive correlation with them. The area under ROC (receiver operating characteristic curve), were more than 0.9 for UAE, ACR, NF, and MTT, and it indicate that these indexes have relatively positive effect on the early diagnosis of the DN. For 24 h UPQ, cysteine C, eGFR and BV value, the area Under the curve are between 0.7 and 0.9, which indicates that diagnosis using those index for the disease were accuracy. Thus, the above indexes have better diagnostic efficiency compared to Scr, BUN and eGFR. Conclusion: The biochemical indexes such as UAE, ACR and renal perfusion indexes such as BF and MTT can be applied in the early predicative diagnosis and DN screening. Its diagnosis effect is better than other biochemical indexes.
VL  - 3
IS  - 1
ER  -

Copy | Download