This study describes cell growth inhibition through invitro, invivo antileishmanial and cytotoxic effect of Resveratrol. Resveratrol was tested at range of concentration of 1 - 10 µg/ml for invitro analysis on L-tropica strain for 24 – 72 h, whereas Sodium Stibogluconate was reference drug. BALB/c mice were subjected to invivo test relative to negative control, while mammalian cells (Lymphocytes) were used in cytotoxic test. After 72 h, tested compound showed significant results against promastigotes at concentration of 1 µg/ml, 2.5 µg/ml, 5 µg/ml, 7.5 µg/ml and 10 µg/ml which were 90.5 ± 0.02, 95.2 ± 0.07, 96.5 ± 0.05, 97.8 ± 0.03 and 98.2 ± 0.04 respectively. After 6 weeks, it showed promising results against intracellular amastigotes in mean lesion size which decrease from 0.9 ± 0.2 mm to 0.25 ± 0.2 mm (p < 0.02) where as 10 mg/kg (dose) was subjected to BALB/c mice which exhibited decrease in percentage cure rate up to 94.01 (95 % C.I = 92.01 – 96.21). IC50 values of lymphocytes showed 14.23 µg/ml (95 % C.I = 10.05 – 17.56) against Resveratrol. After analysis, it was observed that Resveratrol possesses anti-leishmanial activities against the cell growth of L. tropica and has no effect on lymphocytes.
| Published in | Journal of Drug Design and Medicinal Chemistry (Volume 10, Issue 1) |
| DOI | 10.11648/j.jddmc.20241001.12 |
| Page(s) | 8-10 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Resveratrol, Leishmania tropica, Promastigotes, Amastigotes, Mammalian Cell
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APA Style
Iqbal, K., Aziz, Q., Sana, A. (2024). Resveratrol: A Cell Growth Inhibitor Against Leishmania Tropica. Journal of Drug Design and Medicinal Chemistry, 10(1), 8-10. https://doi.org/10.11648/j.jddmc.20241001.12
ACS Style
Iqbal, K.; Aziz, Q.; Sana, A. Resveratrol: A Cell Growth Inhibitor Against Leishmania Tropica. J. Drug Des. Med. Chem. 2024, 10(1), 8-10. doi: 10.11648/j.jddmc.20241001.12
AMA Style
Iqbal K, Aziz Q, Sana A. Resveratrol: A Cell Growth Inhibitor Against Leishmania Tropica. J Drug Des Med Chem. 2024;10(1):8-10. doi: 10.11648/j.jddmc.20241001.12
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Download@article{10.11648/j.jddmc.20241001.12,
author = {Kashif Iqbal and Qaiser Aziz and Ayesha Sana},
title = {Resveratrol: A Cell Growth Inhibitor Against Leishmania Tropica},
journal = {Journal of Drug Design and Medicinal Chemistry},
volume = {10},
number = {1},
pages = {8-10},
doi = {10.11648/j.jddmc.20241001.12},
url = {https://doi.org/10.11648/j.jddmc.20241001.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20241001.12},
abstract = {This study describes cell growth inhibition through invitro, invivo antileishmanial and cytotoxic effect of Resveratrol. Resveratrol was tested at range of concentration of 1 - 10 µg/ml for invitro analysis on L-tropica strain for 24 – 72 h, whereas Sodium Stibogluconate was reference drug. BALB/c mice were subjected to invivo test relative to negative control, while mammalian cells (Lymphocytes) were used in cytotoxic test. After 72 h, tested compound showed significant results against promastigotes at concentration of 1 µg/ml, 2.5 µg/ml, 5 µg/ml, 7.5 µg/ml and 10 µg/ml which were 90.5 ± 0.02, 95.2 ± 0.07, 96.5 ± 0.05, 97.8 ± 0.03 and 98.2 ± 0.04 respectively. After 6 weeks, it showed promising results against intracellular amastigotes in mean lesion size which decrease from 0.9 ± 0.2 mm to 0.25 ± 0.2 mm (p 50 values of lymphocytes showed 14.23 µg/ml (95 % C.I = 10.05 – 17.56) against Resveratrol. After analysis, it was observed that Resveratrol possesses anti-leishmanial activities against the cell growth of L. tropica and has no effect on lymphocytes.},
year = {2024}
}
TY - JOUR T1 - Resveratrol: A Cell Growth Inhibitor Against Leishmania Tropica AU - Kashif Iqbal AU - Qaiser Aziz AU - Ayesha Sana Y1 - 2024/01/23 PY - 2024 N1 - https://doi.org/10.11648/j.jddmc.20241001.12 DO - 10.11648/j.jddmc.20241001.12 T2 - Journal of Drug Design and Medicinal Chemistry JF - Journal of Drug Design and Medicinal Chemistry JO - Journal of Drug Design and Medicinal Chemistry SP - 8 EP - 10 PB - Science Publishing Group SN - 2472-3576 UR - https://doi.org/10.11648/j.jddmc.20241001.12 AB - This study describes cell growth inhibition through invitro, invivo antileishmanial and cytotoxic effect of Resveratrol. Resveratrol was tested at range of concentration of 1 - 10 µg/ml for invitro analysis on L-tropica strain for 24 – 72 h, whereas Sodium Stibogluconate was reference drug. BALB/c mice were subjected to invivo test relative to negative control, while mammalian cells (Lymphocytes) were used in cytotoxic test. After 72 h, tested compound showed significant results against promastigotes at concentration of 1 µg/ml, 2.5 µg/ml, 5 µg/ml, 7.5 µg/ml and 10 µg/ml which were 90.5 ± 0.02, 95.2 ± 0.07, 96.5 ± 0.05, 97.8 ± 0.03 and 98.2 ± 0.04 respectively. After 6 weeks, it showed promising results against intracellular amastigotes in mean lesion size which decrease from 0.9 ± 0.2 mm to 0.25 ± 0.2 mm (p 50 values of lymphocytes showed 14.23 µg/ml (95 % C.I = 10.05 – 17.56) against Resveratrol. After analysis, it was observed that Resveratrol possesses anti-leishmanial activities against the cell growth of L. tropica and has no effect on lymphocytes. VL - 10 IS - 1 ER -
Department of Pharmacy, IBADAT International University, Islamabad, Pakistan
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